Different effects of caffeine on behavioral neurophenotypes of two zebrafish populations

Rosa, Luiz V.; Ardais, Ana Paula; Costa, Fabiano V.; Fontana, Bárbara D.; Quadros, Vanessa A.; Porciúncula, Lisiane O.; Rosemberg, Denis B.

doi:10.1016/j.pbb.2017.12.002

Cited by 53 publications

(50 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, avoidance and shoal cohesion are higher in Tupfel long‐fin (TL) strain, compared to poorer avoidance learning, higher basal cortisol, upregulated telencephalic stress‐axis‐related genes in AB fish (Gorissen et al, ). Likewise, higher anxiety in the novel tank (Egan et al, ) and the light–dark tests, lower tissue serotonin, increased serotonin turnover (Maximino et al, ) and aberrant behavioral (Quadros et al, ) and physiological (Canzian, Fontana, Quadros, & Rosemberg, ) responses to alarm pheromone exposure (Rosa et al, ) are seen in mutant “leopard” ( leo ) versus wild‐type zebrafish (Figure ). Compared to wild zebrafish, domesticated laboratory populations display lower anxiety‐like and avoidance behavior, with multiple differentially expressed brain genes of neuroplasticity, apoptosis, and neurodevelopment (Drew et al, ).…”

Section: Strain and Individual Differences In Zebrafish Cns Modelsmentioning

confidence: 96%

“…Historically, animal experimental models, especially rodents, have been indispensable for studying CNS disorders (Rosa et al, ), G × E (Dick, ; Karl, ; Turner & Burne, ) as well as sex (An et al, ; Jonasson, ; Lonstein & De Vries, ) and strain behavioral differences (Crabbe et al, ; Lassi & Tucci, ; Mozhui et al, ). However, translational biological psychiatry is remarkably empowered by recognizing the evolutionarily conserved nature of brain pathology, with its shared neuropsychiatric domains and traits across species (Gandal et al, ; Power et al, ; Schulze et al, ; Wang et al, ).…”

Section: Zebrafish As a Novel Model Organism For Neuroscience Researchmentioning

confidence: 99%

See 1 more Smart Citation

Zebrafish models for personalized psychiatry: Insights from individual, strain and sex differences, and modeling gene x environment interactions

Volgin

Yakovlev

Demin

et al. 2018

J of Neuroscience Research

View full text Add to dashboard Cite

Currently becoming widely recognized, personalized psychiatry focuses on unique physiological and genetic profiles of patients to best tailor their therapy. However, the role of individual differences, as well as genetic and environmental factors, in human psychiatric disorders remains poorly understood. Animal experimental models are a valuable tool to improve our understanding of disease pathophysiology and its molecular mechanisms. Due to high reproduction capability, fully sequenced genome, easy gene editing, and high genetic and physiological homology with humans, zebrafish (Danio rerio) are emerging as a novel powerful model in biomedicine.Mounting evidence supports zebrafish as a useful model organism in CNS research.Robustly expressed in these fish, individual, strain, and sex differences shape their CNS responses to genetic, environmental, and pharmacological manipulations. Here, we discuss zebrafish as a promising complementary translational tool to further advance patient-centered personalized psychiatry. K E Y W O R D Sgene-environment interactions, individual differences, personalized psychiatry, zebrafish | 403 VOLGIN et aL.

show abstract

Section: Strain and Individual Differences In Zebrafish Cns Modelsmentioning

confidence: 96%

Section: Zebrafish As a Novel Model Organism For Neuroscience Researchmentioning

confidence: 99%

Zebrafish models for personalized psychiatry: Insights from individual, strain and sex differences, and modeling gene x environment interactions

Volgin

Yakovlev

Demin

et al. 2018

J of Neuroscience Research

View full text Add to dashboard Cite

show abstract

“…Despite the well-known zebrafish behavioral repertoire ( Kalueff et al, 2013 ), discrepancies and variability in research outcomes need to be considered. Some sources of variability have already been studied, such as fish personality traits ( Wilson et al, 1994 ; Réale et al, 2007 ), immune status ( Kirsten et al, 2018 ), sex ( Rambo et al, 2016 ; Reolon et al, 2018 ), strains ( Canzian et al, 2017 ; Rosa et al, 2018 ), previous predatory experiences ( Barcellos et al, 2010 ; Abreu et al, 2018 ), and exposure to agrichemicals ( Santos da Rosa et al., 2017 ) and drug residues ( Barcellos et al., 2016 ; Abreu et al, 2016 ; Kalichak et al, 2016 ). These possible interfering factors may impair the reproducibility of the experiments and the accuracy of the results.…”

Section: Introductionmentioning

confidence: 99%

Feeding regimen modulates zebrafish behavior

Dametto

Fior

Idalêncio

et al. 2018

PeerJ

View full text Add to dashboard Cite

Here we show that the feeding regimen modulates zebrafish (Danio rerio) behavior. With regard to the time elapsed between feeding and behavioral evaluation, fish fed 3 h before behavioral evaluation in the novel tank test (NTT) showed decreased activity and a trend toward an anxiolytic reaction (increased use of the upper section of the aquarium) in comparison to fish fed 0.5, 6, 12, 24 or 48 h before testing, although differences were not statistically significant for all comparisons. Activity and use of the upper section of the aquarium did not differ significantly among the other treatments. Regarding feeding frequency, fish fed once a day showed higher anxiety-like behavior (decreased use of the upper section of the aquarium) in comparison to fish fed twice a day, but feeding four or six times per day or only every second day did not result in differences from feeding twice a day. Feeding frequency had no effect on activity level. Metabolically, fish fed once a day presented decreased levels of glucose and glycogen and increased lactate when compared to the regular feeding (fish fed twice a day), suggesting that feeding regimen may modulate carbohydrate metabolism. Mechanistically, we suggest that the metabolic changes caused by the feeding regimen may induce behavioral changes. Our results suggest that the high variability of the results among different laboratories might be related to different feeding protocols. Therefore, if issues pertaining to the feeding regimen are not considered during experiments with zebrafish, erroneous interpretations of datasets may occur.

show abstract

“…On the other hand, the high dose (50 mg/L caffeine) may act on other areas of the brain as well, thereby augmenting stress. Rosa et al (2018) found that 50 mg/L of caffeine increases whole-body cortisol levels in zebrafish. In this regard, we could expect a similar alteration in our experimental fish.…”

Section: Discussionmentioning

confidence: 96%

“…These positive caffeine effects occur only with controlled amounts, since high caffeine levels increase receptor binding in many parts of the brain and body, raise heart rate and blood pressure, and release hormones such as epinephrine and cortisol (Benowitz, 2008;Butt & Sultan, 2011;Franco, Oñatibia-Astibia, & Martínez-Pinilla, 2013;Rosa et al, 2018). In this respect, high amounts of caffeine are usually related to stress and anxiety (Wood, Sage, Shuman, & Anagnostaras, 2014).…”

Section: Discussionmentioning

confidence: 99%

Coffee time: Low caffeine dose promotes attention and focus in zebrafish

2019

View full text Add to dashboard Cite

In this study we investigated the ability of zebrafish to discriminate visual signs and associate them with a reward in an associative-learning protocol including distractors. Moreover, we studied the effects of caffeine on animal performance in the task. After being trained to associate a specific image pattern with a reward (food) in the presence of other, distractor images, the fish were challenged to locate the exact cue associated with the reward. The distractors were same-colored pattern images similar to the target. Both the target and distractors were continually moved around the tank. Fish were exposed to three caffeine concentrations for 14 days: 0 mg/L (control, n = 12), 10 mg/L (n = 14), and 50 mg/L (n = 14). Zebrafish spent most of the time close to the target (where the reward was offered) under the effects of 0 and 10 mg/L caffeine, and the shortest latency to reach the target was observed for the 10-mg/L caffeine group. Both caffeine treatments (10 and 50 mg/L) increased the average speed and distance traveled when compared to the control group. This study confirms previous results showing that zebrafish demonstrate conditioned learning ability; however, low-dose caffeine exposure seems to favor visual cue discrimination and to increase zebrafish performance in a multicue discrimination task, in which primarily focus and attention are required in order to obtain the reward.Caffeine is one of the most consumed stimulants in the world (Ferré, 2008;Lieberman, 1992). It is present in a wide range of products, including coffee, energy drinks, teas, and chocolate. The popularity of this substance lies in its beneficial effects, such as heightened attention and alertness and decreased fatigue

show abstract

Different effects of caffeine on behavioral neurophenotypes of two zebrafish populations

Cited by 53 publications

References 38 publications

Zebrafish models for personalized psychiatry: Insights from individual, strain and sex differences, and modeling gene x environment interactions

Zebrafish models for personalized psychiatry: Insights from individual, strain and sex differences, and modeling gene x environment interactions

Feeding regimen modulates zebrafish behavior

Coffee time: Low caffeine dose promotes attention and focus in zebrafish

Contact Info

Product

Resources

About