Different effect of a restricted diet on isolated uteri of ovariectomized and non-ovariectomized rats. Influence of indomethacin and prostaglandins

Casalino, S.; Linares, J.A.; Goldraij, A

doi:10.1016/0952-3278(94)90176-7

Cited by 10 publications

(3 citation statements)

References 19 publications

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“…Reduced ovarian IGF-1 signaling can lead to increased Foxo signaling levels, a common factor in extension of longevity in primitive species and with dietary restriction. Interestingly, the beneficial effects of dietary restriction on glucose and triglyceride metabolism in intact female rodents do not appear in ovariectomized rodents, supporting a central role for the ovary in female metabolic health (Casalino et al 1994). The observation that naturally menopausal women with reproductively senescent ovaries possess a health advantage over surgically menopausal women suggests that something about the ovary provides a health advantage, independent of active germ cells.…”

Section: Ovarian Transplantationmentioning

confidence: 99%

Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice

et al. 2018

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Cardiovascular disease, rare in premenopausal women, increases sharply at menopause and is typically accompanied by chronic inflammation. Previous work in our laboratory demonstrated that replacing senescent ovaries in post-reproductive mice with young, actively cycling ovaries restored many health benefits, including decreased cardiomyopathy and restoration of immune function. Our objective here was to determine if depletion of germ cells from young transplanted ovaries would alter the ovarian-dependent extension of life and health span. Sixty-day-old germ cell-depleted and germ cell-containing ovaries were transplanted to postreproductive, 17-month-old mice. Mean life span for female CBA/J mice is approximately 644 days. Mice that received germ cell-containing ovaries lived 798 days (maximum = 815 days). Mice that received germ cell-depleted ovaries lived 880 days (maximum = 1046 days), 29% further past the time of surgery than mice that received germ cellcontaining ovaries. The severity of inflammation was reduced in all mice that received young ovaries, whether germ cell-containing or germ cell-depleted. Aging-associated inflammatory cytokine changes were reversed in post-reproductive mice by 4 months of new-ovary exposure. In summary, germ cell depletion enhanced the longevity-extending effects of the young, transplanted ovaries and, as with germ cell-containing ovaries, decreased the severity of inflammation, but did so independent of germ cells. Based on these observations, we propose that gonadal somatic cells are programed to preserve the somatic health of the organism with the intent of facilitating future germline transmission. As reproductive potential decreases or is lost, the incentive to preserve the somatic health of the organism is lost as well.

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Section: Ovarian Transplantationmentioning

confidence: 99%

Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice

et al. 2018

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“…Previous studies by our laboratory showed that glucose metabolism in isolated uteri of adult rats undergoes a significant reduction if the animal is previously exposed to a prolonged restricted diet [1][2][3]. Conversely, in immature rats, a restricted diet delays sexual maturity but fails to affect glucose metabolism [4].…”

Section: Introductionmentioning

confidence: 90%

“…It is known that the derivatives of arachidonic acid influence the metabolism of carbohydrates [1][2][3]5] and that prostaglandin E controls the uterine activity of immature rats [6]. Furthermore, nitric oxide (NO), synthesized from arginine by nitric oxide synthase (NOS) is involved in numerous physiological processes [7], amongst which lies glucose metabolism [8,9].…”

Section: Introductionmentioning

confidence: 99%

Glucose metabolism in isolated uteri of immature rats. Influence of prostaglandins and nitric oxide

2006

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-We studied the contractile activity and glucose metabolism, in terms of production of 14 CO 2 from [ 14 C] glucose, in isolated uteri of immature rats. Immaturity was due to age or exposure to a restricted diet. The contractile activity in both prepubertal groups persisted for a period of 60 minutes and fell when indomethacin was added to the KRB medium. The production of 14 CO 2 was greater than for adult rats and fell as a result of the addition of indomethacin. The metabolism of [ 14 C] arachidonic acid showed that the percentage of eicosanoids released in age related immature uteri was greater than that in restricted diet related immature uteri. In animals that are immature as a result of exposure to a restricted diet, 14 CO 2 fell due to the effect of NAME. Sodium nitroprusside and L-arginine increased the production of 14 CO 2 . This effect was reverted by NAME and indomethacin. Conversely, the uteri of age related prepubertal rats were not affected. The level of activity of nitric oxide synthase was higher in restricted diet related immature animals and fell following the addition of NS-398. We may conclude that in rats exposed to a restricted diet, NO and COX-2 participate in glucose metabolism whereas they would not be involved in age related prepubertal animals.immature rats / glucose metabolism / nitric oxide / arachidonic acid

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Chronological and reproductive aging-associated changes in resistance to oxidative stress in post-reproductive female mice

et al. 2023

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Different effect of a restricted diet on isolated uteri of ovariectomized and non-ovariectomized rats. Influence of indomethacin and prostaglandins

Cited by 10 publications

References 19 publications

Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice

Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice

Glucose metabolism in isolated uteri of immature rats. Influence of prostaglandins and nitric oxide

Chronological and reproductive aging-associated changes in resistance to oxidative stress in post-reproductive female mice

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