Different doses of estradiol benzoate induce conditioned place preference after paced mating

Corona, Rebeca; Camacho, F.; García-Horsman, Patricia; Guerrero, Ana Luisa Guerrero; Ogando, Annette; Paredes, Raúl G.

doi:10.1016/j.yhbeh.2011.05.013

Cited by 16 publications

(9 citation statements)

References 28 publications

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“…Sexually experienced female Wistar rats (200–300 g) were used as stimulus. They were gonadectomized and brought into estrous by hormone treatment with 25 μg/rat of estradiol benzoate (Sigma) 48 h before and with 1mg/rat of progesterone (Aldrich) 4 h before the mating test (Gonzalez-Flores et al, 2004; Arzate et al, 2011; Corona et al, 2011a). In order to acquire sexual experience males mated in a condition where they were allow to pace the sexual interaction with sexually receptive females in three 30 min tests, one test per week.…”

Section: Methodsmentioning

confidence: 99%

Sexual activity increases the number of newborn cells in the accessory olfactory bulb of male rats

Portillo¹,

Unda²,

Camacho³

et al. 2012

Front. Neuroanat.

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In rodents, sexual behavior depends on the adequate detection of sexually relevant stimuli. The olfactory bulb (OB) is a region of the adult mammalian brain undergoing constant cell renewal by continuous integration of new granular and periglomerular neurons in the accessory (AOB) and main (MOB) olfactory bulbs. The proliferation, migration, survival, maturation, and integration of these new cells to the OB depend on the stimulus that the subjects received. We have previously shown that 15 days after females control (paced) the sexual interaction an increase in the number of cells is observed in the AOB. No changes are observed in the number of cells when females are not allowed to control the sexual interaction. In the present study we investigated if in male rats sexual behavior increases the number of new cells in the OB. Male rats were divided in five groups: (1) males that did not receive any sexual stimulation, (2) males that were exposed to female odors, (3) males that mated for 1 h and could not pace their sexual interaction, (4) males that paced their sexual interaction and ejaculated one time and (5) males that paced their sexual interaction and ejaculated three times. All males received three injections of the DNA synthesis marker bromodeoxyuridine at 1h intervals, starting 1 h before the beginning of the behavioral test. Fifteen days later, males were sacrificed and the brains were processed to identify new cells and to evaluate if they differentiated into neurons. The number of newborn cells increased in the granular cell layer (GrCL; also known as the internal cell layer) of the AOB in males that ejaculated one or three times controlling (paced) the rate of the sexual interaction. Some of these new cells were identified as neurons. In contrast, no significant differences were found in the mitral cell layer (also known as the external cell layer) and glomerular cell layer (GlCL) of the AOB. In addition, no significant differences were found between groups in the MOB in any of the layers analyzed. Our results indicate that sexual behavior in male rats increases neurogenesis in the GrCL of the AOB when they control the rate of the sexual interaction.

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Section: Methodsmentioning

confidence: 99%

Sexual activity increases the number of newborn cells in the accessory olfactory bulb of male rats

Portillo¹,

Unda²,

Camacho³

et al. 2012

Front. Neuroanat.

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“…Recently, Corona et al (2011) reported that a threshold amount of estradiol is required for paced copulation to induce significant CPP. In that study, separate groups of sexually naïve female albino (Wistar) rats were OVX and treated with 25, 5, 2.5, 1.25, or 0.625 μg of EB 48 h and 0.5 mg of P 4 h before each of six alternating test sessions of paced copulation (ended after 10-15 intromissions with the male) vs. no sex and paired with one side of a conditioned place preference chamber.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, paced copulation or distributed CLS induce a conditioned partner preference in female rats for males bearing an odor (e.g., almond) associated with the sexual reward state (Coria-Avila et al, 2005;Parada et al, 2011), an effect that was abolished by systemic administration of the opioid antagonist naloxone for paced copulation (Coria-Avila et al, 2008a, 2008b but not flupenthixol (Coria-Avila et al, 2008a, 2008b, showing the dependence of sexual reward on the activation of opioid systems. Corona, Camacho, Garcia-Horsman, Guerrero, Ogando, and Paredes (2011) reported recently that a threshold amount of estradiol is required for paced copulation to induce a significant CPP. Significant CPP developed in all but the group receiving the lowest dose of EB, suggesting that for paced copulation to induce a reward state sufficient to support CPP a threshold amount of estradiol is necessary.…”

Section: Introductionmentioning

confidence: 99%

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The role of ovarian hormones in sexual reward states of the female rat

Parada

Vargas

Kyres

et al. 2012

Hormones and Behavior

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“…When copulation occurs, the female rat is prepared not only to accept the male and receive sexual stimulation (clitoral and vaginocervical), but also her brain is in a hormonal state that facilitates learning. The effect of hormones, and sexual stimulation are required for female rats to develop conditioned partner preferences triggered by sexual stimuli (Parada et al, 2010;Corona et al, 2011;Parada et al, 2011;Pfaus et al, 2012).…”

Section: Natural Stimuli For Intraspecific Attachmentmentioning

confidence: 99%

Neurobiology of social attachments

Coria-Ávila

Manzo

Hernández

et al. 2014

Neuroscience & Biobehavioral Reviews

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a b s t r a c tMany types of social attachments can be observed in nature. We discuss the neurobiology of two types (1) intraspecific (with a partner) and (2) parental (with the offspring). Stimuli related to copulation facilitate the first, whereas pregnancy, parturition and lactation facilitate the second. Both types develop as consequence of cohabitation. These events seem to stimulate similar neural pathways that increase (1) social recognition, (2) motivation, reward; and (3) decrease fear/anxiety. Subregions of the amygdala and cortex facilitate social recognition and also disinhibition to decrease rejection responses. The interrelationship between MeA, BNST, LS may mediate the activation of NAcc via the mPOA to increase motivation and reward. Cortical areas such as the ACC discriminate between stimuli. The interaction between OT and D2-type receptors in NAcc shell facilitates intraspecific attachment, but D1-type appears to facilitate parental attachment. This difference may be important for maternal females to direct their attention, motivation and expression of attachment toward the appropriate target.

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Different doses of estradiol benzoate induce conditioned place preference after paced mating

Cited by 16 publications

References 28 publications

Sexual activity increases the number of newborn cells in the accessory olfactory bulb of male rats

Sexual activity increases the number of newborn cells in the accessory olfactory bulb of male rats

The role of ovarian hormones in sexual reward states of the female rat

Neurobiology of social attachments

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