Different distribution of Cryptosporidium species between horses and donkeys

Li, Falei; Su, Jiayuan; Chahan, Bayin; Guo, Qingyong; Wang, Tao; Yu, Zhengjie; Guo, Yaqiong; Li, Na; Feng, Yaoyu; Xiao, Lihua

doi:10.1016/j.meegid.2019.103954

Cited by 24 publications

(18 citation statements)

References 48 publications

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“…As IbA10G2 is one of the most prevalent subtypes in humans in many countries and is also a major cause of waterborne outbreaks [ 1 , 11 , 38 ], this further supports a human origin for C. hominis in animals. In equines and particularly donkeys and horses, the Ik C. hominis subtype family (which is relatively rare in humans) is endemic and a reservoir of infection for humans [ 135 , 136 , 137 , 138 ]. Studies in Australia also suggest that C. hominis may become endemic in marsupials [ 131 , 139 , 140 ].…”

Section: Zoonotic Cryptosporidium Species and Genotypesmentioning

confidence: 99%

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An Update on Zoonotic Cryptosporidium Species and Genotypes in Humans

Ryan

Zahedi

Feng

et al. 2021

Animals

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115

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The enteric parasite, Cryptosporidium is a major cause of diarrhoeal illness in humans and animals worldwide. No effective therapeutics or vaccines are available and therefore control is dependent on understanding transmission dynamics. The development of molecular detection and typing tools has resulted in the identification of a large number of cryptic species and genotypes and facilitated our understanding of their potential for zoonotic transmission. Of the 44 recognised Cryptosporidium species and >120 genotypes, 19 species, and four genotypes have been reported in humans with C. hominis, C. parvum, C. meleagridis, C. canis and C. felis being the most prevalent. The development of typing tools that are still lacking some zoonotic species and genotypes and more extensive molecular epidemiological studies in countries where the potential for transmission is highest are required to further our understanding of this important zoonotic pathogen. Similarly, whole-genome sequencing (WGS) and amplicon next-generation sequencing (NGS) are important for more accurately tracking transmission and understanding the mechanisms behind host specificity.

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Section: Zoonotic Cryptosporidium Species and Genotypesmentioning

confidence: 99%

“…The horse genotype is commonly reported in donkeys and horses [ 135 , 137 , 138 ]. Typing of the horse genotype at the gp60 locus has identified subtype families VIa, VIb and VIc [ 31 , 51 ].…”

Section: Zoonotic Cryptosporidium Species and Genotypesmentioning

confidence: 99%

An Update on Zoonotic Cryptosporidium Species and Genotypes in Humans

Ryan

Zahedi

Feng

et al. 2021

Animals

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115

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“…To date, three Cryptosporidium species (C. parvum, C. muris, and C. hominis) and only one genotype (Cryptosporidium horse genotype) have been identified in donkeys [14,16,17]. In the present study, 16 Cryptosporidium-positive specimens underwent successful sequencing of the SSU rDNA gene.…”

Section: Resultsmentioning

confidence: 76%

“…Some donkeys are raised for milk or meat, as well as for making Ejiao, a traditional Chinese medicine product. To our knowledge, only two reports have been published about Cryptosporidium infection of donkeys in China [14,17]. The present study aimed to determine the prevalence and zoonotic potential of Cryptosporidium in free-ranging and scale-farmed donkeys in Xinjiang, China.…”

Section: Introductionmentioning

confidence: 94%

Prevalence and genotypic identification of Cryptosporidium in free-ranging and farm-raised donkeys (Equus asinus asinus) in Xinjiang, China

Wang

Zhang

et al. 2020

Parasite

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The prevalence and zoonotic potential of Cryptosporidium in donkeys is poorly understood. Here, 680 fecal specimens were collected from 178 free-ranging and 502 farmed donkeys in Xinjiang, China. Cryptosporidium was identified using PCR amplification of the small subunit of ribosomal DNA. Cryptosporidium-positive isolates were subtyped using PCR analysis of the 60 kDa glycoprotein gene (gp60). The overall prevalence of Cryptosporidium was 2.4% (16/680), with 3.2% (16/502) in farmed donkeys and 0% (0/178) in free-ranging donkeys. Cryptosporidium hominis (n = 13), C. parvum (n = 1) and Cryptosporidium horse genotype (n = 2) were identified. The C. hominis isolates belonged to two subtypes, IkA16 (n = 9) and IkA16G1 (n = 4). The subtype of C. parvum was IIdA15G1, whereas the two Cryptosporidium horse genotype isolates were of subtype VIaA15G4. The predominance of C. hominis in donkeys suggests that these animals are infected through human contact.

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“…in different studies may be explained by many factors, including the population densities, health status of hosts, management systems, experimental method and source region[41].Altogether, four Cryptosporidium genotypes were identi ed in this study. One known horse genotype was originally isolated from a Prezewalski wild horse at the Prague Zoo in Czech Republic, and commonly detected in horses and donkeys, occasionally found in neonatal calves and hedgehogs[42,43]. It has also been found in human patients with diarrhea in the UK and USA, suggesting its zoonotic potential[44][45][46].…”

mentioning

confidence: 99%

Genotyping and subtyping of Cryptosporidium spp. and Giardia duodenalis isolates from two wild rodent species in Gansu Province, China

Liu

Jiang

et al. 2021

Preprint

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Cryptosporidium spp. and Giardia duodenalis are common detected intestinal protozoa species in humans and animals, contributing to global gastroenteritis spread. In the present study, we examined the prevalence and zoonotic potential of Cryptosporidium spp. and G. duodenalis in two rodent species in Qinghai-Tibetan Plateau area (QTPA) of China for the first time. A total of 498 intestinal content samples were collected from five counties of QTPA of Gansu province, China. Cryptosporidium spp. and G. duodenalis were found in 2.5% (10/399) and 1.5% (6/399) of Himalayan marmots, while in 1.0% (1/99) and 2.0% (2/99) of Alashan ground squirrels, respectively. Four Cryptosporidium genotypes were identified, including one known horse genotype (n=1) and three novel genotypes designated as marmot genotype I (n = 7), marmot genotype II (n = 2) and marmot genotype III (n = 1). The horse genotype was further subtyped as novel subtype VIbA10. G. duodenalis zoonotic assemblages A (n = 1), B (n = 6), E (n = 1) were identified in the present study. This is the first study to identify Cryptosporidium spp. and G. duodenalis in the two wild rodent species worldwide, suggesting the potential zoonotic transmission of the two pathogens in QTPA.

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Different distribution of Cryptosporidium species between horses and donkeys

Cited by 24 publications

References 48 publications

An Update on Zoonotic Cryptosporidium Species and Genotypes in Humans

An Update on Zoonotic Cryptosporidium Species and Genotypes in Humans

Prevalence and genotypic identification of Cryptosporidium in free-ranging and farm-raised donkeys (Equus asinus asinus) in Xinjiang, China

Genotyping and subtyping of Cryptosporidium spp. and Giardia duodenalis isolates from two wild rodent species in Gansu Province, China

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