Different descending pathways mediate early and late portions of lower limb responses to transcranial magnetic stimulation
Jonathan Shemmell,
Carrie Falling,
Colum D. MacKinnon
et al.
Abstract:While recent studies in non-human primates have provided evidence that transcranial magnetic stimulation (TMS) activates cells within the reticular formation, it remains unclear whether descending brainstem projections contribute to the generation of TMS-induced motor evoked potentials (MEPs) in skeletal muscles. We compared MEPs in muscles with extensive direct corticomotoneuronal input (first dorsal interosseous) versus a prominent role in postural control (gastrocnemius) to determine whether the amplitude o… Show more
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