Different cytokine profiles of intraphepatic T cells in chronic hepatitis B and hepatitis C virus infections

Bertoletti, Antonio; D’Elios, Mario Milco; Boni, Carolina; Carli, Marco De; Zignego, A.L.; Durazzo, Marilena; Missale, Gabriele; Penna, Amalia; Fiaccadori, F; Prete, Gianfranco Del; Ferrari, Carlo

doi:10.1016/s0016-5085(97)70235-x

Cited by 283 publications

(211 citation statements)

References 4 publications

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“…It has been hypothesised that successful treatment of hepatitis C depends on a complex balance between pro and anti-inflammatory responses (Bertoletti et al 1997, Tsai et al 2003, Wan et al 2009). In our study, we found both pro and anti-inflammatory responses, with a predominant pro-inflammatory response pattern in the liver mediated by IFN-γ and TNF-α and modulated by CD4 + , CD8 + and CD45RO + T lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

Tissue and serum immune response in chronic hepatitis C with mild histological lesions

R-Viso¹,

Duarte²,

Pagliari³

et al. 2010

Mem. Inst. Oswaldo Cruz

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Section: Discussionmentioning

confidence: 99%

Tissue and serum immune response in chronic hepatitis C with mild histological lesions

R-Viso¹,

Duarte²,

Pagliari³

et al. 2010

Mem. Inst. Oswaldo Cruz

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“…That sTNF-R2 is independently associated with HCC after adjusting for sICAM-1 and sCD30 may reflect the significance of the immune response that is triggered by the binding of TNF-a to sTNF-R2 (44,52). Because elevated levels of TNF-a are found in chronic HCV infection (26), it is possible that the cytotoxic T cells recruited by the TNF-a signaling system are more important in exacerbating ongoing liver injury.…”

Section: Discussionmentioning

confidence: 99%

Host Immune Status and Incidence of Hepatocellular Carcinoma among Subjects Infected with Hepatitis C Virus: A Nested Case-Control Study in Japan

Suruki¹,

Müeller²,

Hayashi

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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A nested case-control study was conducted to examine the association between host immune status, as characterized by serum immune marker levels, and the development of hepatocellular carcinoma (HCC) up to 8 years later in persons with chronic hepatitis C virus (HCV) infection. Cases (n = 39) and matched controls (n = 117) were selected from participants of the Town C HCV Study in Japan between 1996 and 2004 and matched on age at first available sample (F1 year), gender, and length of follow-up. Separate analyses were done for each of three serum immune markers: soluble tumor necrosis factor-receptor II (sTNF-R2) and soluble intercellular adhesion molecule-1 (sICAM-1), as indicators of type 1, cell-mediated immune response, and soluble CD30 (sCD30), as an indicator of type 2, humoral immune response. The median concentrations of sTNF-R2, sICAM-1, and sCD30 among controls were 3,170 pg/mL, 305 ng/mL, and 3.0 units/mL, respectively, and were higher among cases (3,870 pg/mL, 372 ng/mL, and 3.3 units/mL, respectively). The risk of developing HCC among subjects with immune marker concentrations above the median levels of the controls was >2-fold greater than among subjects with lower concentrations for all three markers [sTNF-R2: odds ratio (OR), 6.9; 95% confidence interval (95% CI), 2.4-20.5; sICAM-1: OR, 2.0; 95% CI, 0.9-4.1; and sCD30: OR, 2.1; 95% CI, 1.0-4.7]. Simultaneous adjustment for all three markers revealed only sTNF-R2 to be associated with HCC risk (OR, 6.4; 95% CI, 2.0-20.6). Adjustment for alcohol consumption and HCV serotype did not materially alter these associations. Results from this prospective, community-based study suggest that a dysregulation in both type 1 -related and type 2 -related host immunity contributes to the development of HCV-associated HCC. (Cancer Epidemiol Biomarkers Prev 2006;15(12):2521 -5)

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“…24 In one of these reports, Baan et al 25 showed that preferential production of IL-4 was associated with a hyporesponsive state without allograft rejection, whereas chronic liver allograft rejection was characterized by an increased detection of TH1 lymphokine messenger RNA. 26 Bertoletti et al 27 investigated the lymphokine profile of liver-infiltrating CD4ϩ T-cell clones generated with PHA of patients with CH-C and showed that the majority of the T lymphocytes produced TH1 (IFN-␥) lymphokines. Koziel et al 28 found, in HCV-specific cytotoxic T lymphocytes, cytokines that included IFN-␥, tumor necrosis factor-␣, IL-8, and IL-10 that were produced in an antigen-and HLA class I-specific manner.…”

Section: Discussionmentioning

confidence: 99%

Cytokine profile of liver- and blood-derived nonspecific T cells after liver transplantation: T helper cells type 1/0 lymphokines dominate in recurrent hepatitis C virus infection and rejection

Schirren¹,

Jung²,

Worzfeld

et al. 2000

Liver Transpl

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Different cytokine profiles of intraphepatic T cells in chronic hepatitis B and hepatitis C virus infections

Cited by 283 publications

References 4 publications

Tissue and serum immune response in chronic hepatitis C with mild histological lesions

Tissue and serum immune response in chronic hepatitis C with mild histological lesions

Host Immune Status and Incidence of Hepatocellular Carcinoma among Subjects Infected with Hepatitis C Virus: A Nested Case-Control Study in Japan

Cytokine profile of liver- and blood-derived nonspecific T cells after liver transplantation: T helper cells type 1/0 lymphokines dominate in recurrent hepatitis C virus infection and rejection

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