Different collagen types define two types of idiopathic epiretinal membranes

Kritzenberger, Michaela; Junglas, Benjamin; Framme, Carsten; Helbig, Horst; Gabel, Virginie; Fuchshofer, Rudolf; Tamm, Ernst R.; Hillenkamp, Jost

doi:10.1111/j.1365-2559.2011.03820.x

Cited by 61 publications

(66 citation statements)

References 65 publications

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“…ERM consists of a sheet of fibrotic tissue that varies in thickness from a single layer of collagen with interspersed cells to a thicker, multilayered fibrocellular proliferation4243. Although the pathogenesis of ERM has not yet been fully elucidated, the formation and progression of ERM can be regarded as a fibrotic process because the pathologic findings include increased ECM protein deposition and membrane contraction in which myofibroblasts play a crucial role1.…”

Section: Discussionmentioning

confidence: 99%

The Association between Smoking and Epiretinal Membrane

Wang

Tong

Wang

et al. 2016

Sci Rep

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We conducted a meta-analysis of analytic and observational studies to evaluate the association between smoking and epiretinal membrane (ERM). The pertinent studies were identified via a literature search using three databases (MEDLINE, Cochrane Library, Embase) and the reference lists of retrieved studies. Cohort, case-control and cross-sectional studies meeting the predefined criteria were included. We extracted the odds ratios (OR) and 95% confidence intervals (CI) from each study. Overall risk estimates were pooled using random-effects models. Subgroup analyses based on several stratified factors were also performed. Two cohort studies and six cross-sectional studies involving 46,837 subjects were included. The pooled effect of all eight studies showed an unexpected significant decreased association between smoking and the occurrence of ERM (OR, 0.72; 95% CI 0.61–0.84; p = 0.29, I2 = 17.9%). Subgroup analyses supported this finding, except for the age-unadjusted group (OR, 0.87; 95% CI 0.63–1.22), the ERM classification group (cellophane macular reflex (CMR) OR, 0.93; 95% CI 0.68–1.28; preretinal macular fibrosis (PMF) OR, 0.74; 95% CI 0.41–1.32), the Asian group (OR, 0.75; 95% CI 0.52–1.09) and the past smoker group (OR, 1.02; 95% CI 0.85–1.22). The pooled effects from the current literature suggested a declining association between smoking and ERM, which requires further studies to confirm.

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Section: Discussionmentioning

confidence: 99%

The Association between Smoking and Epiretinal Membrane

Wang

Tong

Wang

et al. 2016

Sci Rep

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“…20,21,29 The high rate of PMF in adults may be explained by the unusually high rate of non-idiopathic adult ERM in his study; the secondary etiology of ERM may cause greater activation of myofibroblasts which synthesize collagen types I and II, which are associated with PMF, as part of the healing response to the primary insult. 30 Most adult cases were classified as PMF primarily due to the high incidence of retinal folds on the infrared fundus image, which has been reported to detect more folds than are observed clinically. 31 The finding of folds was later supported by the nearly unanimous presence of “ripple” retinal folds on the adult SDOCT scans.…”

Section: Discussionmentioning

confidence: 99%

Spectral Domain Optical Coherence Tomography Characterization of Pediatric Epiretinal Membranes

Rothman

Folgar

Tong

et al. 2014

Retina

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Purpose To compare macular morphology of pediatric versus adult eyes with epiretinal membrane (ERM) using spectral-domain optical coherence tomography (SDOCT) and identify characteristics associated with postoperative visual acuity (VA). Methods This retrospective study analyzed SDOCT from pediatric subjects and a randomly-selected cohort of adult subjects with ERM. Morphologic retinal and ERM features were graded by two masked SDOCT readers and compared with postoperative change in VA. Results Pediatric ERMs (ages 0.3-16.5 years) were more confluently attached to the retina than adult ERMs (ages 40-88 years, p=0.009) and had less fibrillary appearance of the inner retina when separation was present (p=0.044). Pediatric ERMs were associated with more vessel dragging (p=0.019) and less external limiting membrane (ELM, p=0.001) and inner segment (IS) band visibility (p=0.010), with a trend towards foveal sparing by ERM (p=0.051) and “taco” retinal folds (p=0.052) compared to adult eyes. VA improvement was associated with intact (p=0.048) and smooth (p=0.055, trend) IS band in children and with smooth IS band (p=0.083, trend) and visible ELM (p=0.098, trend) in adults. Conclusion We identified morphologic differences between pediatric and adult ERM on SDOCT. Similar to adults, photoreceptor integrity with pediatric ERM appears to predict better VA changes after surgical ERM removal.

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“…Criteria of difficult ILM/ERM peeling were subjectively documented by the surgeons as the presence of a strong adhesion between the ILM/ERM complex and the underlying retina, or the fragility of the ILM/ERM complex. 24 …”

Section: Patientsmentioning

confidence: 97%