Different cognitive profiles on standard behavioral tests in Parkinson's disease and Alzheimer's disease

Sullivan, E. V.; Sagar, H. J.; Gabrieli, John D. E.; Corkin, Suzanne; Growdon, John H.

doi:10.1080/01688638908400937

Cited by 56 publications

(42 citation statements)

References 37 publications

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“…This subtest has been reported to be a sensitive measure of frontal lobe0executive function integrity (cf. McFie & Thompson, 1972;Sullivan et al, 1989).…”

Section: Executive Functionmentioning

confidence: 98%

Dissociation of remote and anterograde memory impairment and neural correlates in alcoholic Korsakoff syndrome

Fama

Marsh²,

Sullivan

2004

J. Inter. Neuropsych. Soc.

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Alcoholic Korsakoff's syndrome (KS) is marked by remote memory impairment together with characteristic profound anterograde memory deficits. Despite previous studies of memory processes in KS, questions remain regarding the nature and severity of these impairments and identification of brain systems that underlie these different memory impairments. This study examined remote and anterograde memory function in 5 KS patients in comparison with 8 patients with Alzheimer's disease (AD) and 24 normal control subjects (NC). In addition, relationships between memory performance and regional brain volumes were examined in the KS group. Overall, the KS group showed severe impairment on both remote and anterograde memory measures, performing at the level of the AD group on most measures. Differences were observed on the pattern of temporal gradient for verbal recognition, with KS exhibiting a more steeply graded rate of decline over the most recent period examined. Severity of the remote memory deficit in KS was not associated with severity of anterograde memory deficit. Examination of brain structure-function relationships in the KS subjects revealed that photo naming of remote historical information was related to posterior cortical white matter volumes but not hippocampal volumes; sequencing was related to prefrontal but not hippocampal volumes. By contrast, a measure of anterograde memory for nonverbal visual material showed a relationship to hippocampal but not regional cortical white matter volumes. This set of dissociations, which parallels that observed in our earlier study of AD, is now documented in KS and provides further evidence that these separate cortical and limbic brain systems are principal neural substrates of the remote and anterograde memory and sequencing deficits in KS.

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“…This subtest has been reported to be a sensitive measure of frontal lobe0executive function integrity (cf. McFie & Thompson, 1972;Sullivan et al, 1989).…”

Section: Executive Functionmentioning

confidence: 98%

Dissociation of remote and anterograde memory impairment and neural correlates in alcoholic Korsakoff syndrome

Fama

Marsh²,

Sullivan

2004

J. Inter. Neuropsych. Soc.

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“…Studies using wellknown standardized intelligence quotients (IQ) such as the Wechsler Adult Intelligence Scale (WAIS; Wechsler, 1955), or the Wechsler Adult Intelligence Scale-Revised (WAIS-R; Wechsler, 1981), for example, have revealed very few differences between nondemented patients with PD and normal controls (NC) (Bondi et al, 1993;Cooper et al, 1991;Gotham et al, 1988;Lees & Smith, 1983;Matison et al, 1982;McFadden et al, 1996;Sullivan et al, 1989). Those studies that have reported WAIS-R deficits in nondemented PD patients have found them almost exclusively on Performance subtests (Bondi et al, 1993;Cooper et al, 1991;Mohr et al, 1990;Ross et al, 1996), although one study reported that nondemented patients with PD and NC subjects differed on several WAIS Verbal subtests (Ross et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Detection of mild cognitive deficits in Parkinson's disease patients with the WAIS–R NI

Peavy

Salmon

Bear

et al. 2001

J Int Neuropsychol Soc

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The relative insensitivity of traditional IQ tests to mild cognitive deficits has led investigators to develop a version of the widely used Wechsler intelligence scales that allows quantitative analysis of underlying qualitative responses. This instrument, the Wechsler Adult Intelligence Scale-Revised as a Neuropsychological Instrument (WAIS-R NI) was administered to 16 Parkinson's disease (PD) patients and 30 normal controls (NC). The 2 groups did not differ significantly in mean age or education, or on their mean Mattis Dementia Rating Scale score. Relative to NC participants, PD patients showed decreased visual attention span, longer response latencies, slower visuomotor processing, and more stimulus-bound errors. Many of the WAIS-R NI measures were able to detect cognitive impairment in a greater percentage of patients than the traditional WAIS-R measures, making it easier to identify deficits that could affect quality of life early in the course of the disease. (JINS, 2001, 7, 535-543.)

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“…PD patients have been shown to be impaired on picture arrangement tests in which scrambled picture sets must be reordered to tell a story [3,12,49] and on related tasks entailing ordering and organizing script information that is presented as action sequence components in a scrambled order [23,52].…”

Section: Introductionmentioning

confidence: 99%

Fronto-striatal deficit in Parkinson's disease during semantic event sequencing

Tinaz

Schendan

Stern

2008

Neurobiology of Aging

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Studies of Parkinson's disease (PD) suggest that cognitive deficits accompany the classically recognized motor symptoms, and that these cognitive deficits may result from damage to frontalbasal ganglia circuits. PD patients are impaired on ordering events and action components into coherent sequences. In this study, we examined early-stage, nondemented, medicated PD subjects and matched control subjects during a semantic event sequencing task using functional MRI (fMRI). The task required subjects to examine four pictures of meaningful events, determine the correct temporal relationship between each picture, and re-order the pictures into a coherent sequence. There were two main findings. First, we found abnormal activation within the prefrontal cortex (PFC) and the "default" network in the PD group. Distinct areas of the PFC showed both hypoactivation and hyperactivation, whereas the "default" network showed reduced levels of resting activation in PD. Secondly, we observed left caudate hyperactivation in the PD group. The findings are discussed in relationship to how more activation may be compensatory, but does not necessarily mean efficient and correlated brain function.

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Different cognitive profiles on standard behavioral tests in Parkinson's disease and Alzheimer's disease

Cited by 56 publications

References 37 publications

Dissociation of remote and anterograde memory impairment and neural correlates in alcoholic Korsakoff syndrome

Dissociation of remote and anterograde memory impairment and neural correlates in alcoholic Korsakoff syndrome

Detection of mild cognitive deficits in Parkinson's disease patients with the WAIS–R NI

Fronto-striatal deficit in Parkinson's disease during semantic event sequencing

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