Different clinical presentation of interstitial cystitis syndrome

Abstract

The aim of the study was to examine how interstitial cystitis (IC) initiates its clinical course, which changes as the disease progresses from the initial phase to its full clinical manifestation. Patients diagnosed with IC between 1998 and 2003 in our department were evaluated and reviewed regularly. The exact onset of urinary symptoms was recorded. Diagnosis of IC was made by National Institute of Diabetes and Digestive and Kidney Disease (NIDDK) criteria when clinical suspicion of IC was present. The study group included 30 female patients who were 27-69 years old when diagnosis was made. Mean age was 46.7. Seventy percent of patients had only one symptom at onset. The most frequent initial diagnosis was urinary tract infection (UTI). A condition of recurrent bacterial UTIs, with subsequent persistence of symptoms and negative cultures, could be detected as a harbinger of IC in 60% of our patient group. IC may manifest initially with a single symptom in its early stage, when diagnosis is perhaps less easy, but adequate and effective treatment can still be offered to the patient.

Acute colonic inflammation triggers detrusor instability via activation of TRPV1 receptors in a rat model of pelvic organ cross-sensitization

“…Development of cross-sensitization in the pelvis is one of the suggested mechanisms underlying comorbidity of pelvic disorders that is frequently observed in the clinical setting (2,37). Comorbid disorders are characterized by complex symptomatology and unclear underlying mechanisms, making them extremely difficult to cure.…”

“…neurogenic inflammation; chronic pelvic pain; detrusor; contractility COMORBIDITY OF CLINICAL CONDITIONS characterized by chronic pelvic pain (CPP) has recently gained extra attention from physicians and scientists. Painful bladder syndrome/interstitial cystitis, irritable bowel syndrome, nonbacterial prostatitis/CPP syndrome, vulvodynia, and dysmenorrhea form a group of functional disorders with CPP of unknown etiology with the rate of concurrent diagnoses reaching up to 30 -40% (2,37).…”

Time of symptom onset and histologic findings in bladder pain syndrome/interstitial cystitis: new findings on useful correlations

“…19 During most of the twentieth century interstitial cystitis was diagnosed as a result of the cystoscopic detection of Hunner's ulcers.…”

Assessing Urgency in Interstitial Cystitis/Painful Bladder Syndrome

“…To evaluate eligibility, we had to identify a time interval in which to query symptoms. Onset of disease appeared to be inappropriate as two studies reported that not all characteristic IC/PBS symptoms were experienced at onset 15,16 . In that we were not performing a prevalence study, assessing symptoms at interview was unnecessary and we did not want to exclude patients whose symptoms had ebbed.…”