Different clinical outcomes of acute kidney injury according to acute kidney injury network criteria in patients between ST elevation and non-ST elevation myocardial infarction

Hwang, Seung Hwan; Jeong, Myung Ho; Ahmed, Khurshid; Kim, Min Chul; Cho, Kyung Hoon; Lee, Min Goo; Ko, Jum Suk; Park, Keun Ho; Sim, Doo Sun; Yoon, Nam Sik; Yoon, Hyun Ju; Kim, Kye Hun; Hong, Young Joon; Park, Hyung Wook; Kim, Ju Han; Ahn, Young Keun; Cho, Jeong Gwan; Park, Jong Chun; Kang, Jung Chaee

doi:10.1016/j.ijcard.2011.03.039

Cited by 23 publications

(28 citation statements)

References 9 publications

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“…First, patients who develop AKI have a higher prevalence of comorbidities such as diabetes mellitus, hypertension, and CKD, each of which may increase the risk of kidney failure and death. 2 Secondly, significant differences were observed in the type of AMI treatment received by the two groups in this study. For example, patients in the AKI group were significantly less likely to receive some pharmacological therapies or to undergo interventional procedures.…”

Section: Rate Of Aki N (%)mentioning

confidence: 70%

“…Most studies have focused on the long-term mortality but few on the short-term outcomes. 11,23 This current study looked at short-term outcomes and for the first time found that an admission eGFR of <60 ml/min/1.73m 2 with AKI was significantly associated with in-hospital mortality. This means that patients with either chronic or acute renal dysfunction are at a very high risk for inhospital mortality, which might reflect the underlying mechanisms that adversely affect both cardiac and renal function.…”

Section: Rate Of Aki N (%)mentioning

confidence: 76%

“…Acute kidney injury (AKI; previously known as acute renal failure) is a common complication that affects patients with various clinical conditions, such as acute myocardial infarction (AMI), [1][2][3] congestive heart failure; 4 and those undergoing cardioangiography (CAG) 5 and percutaneous coronary intervention (PCI). 6 Recent studies suggest that AKI is associated with poor outcomes and independently predicts increasing long-term mortality.…”

Section: Introductionmentioning

confidence: 99%

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Renal function, acute kidney injury and hospital mortality in patients with acute myocardial infarction

et al. 2014

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Objectives: To examine retrospectively the relationship between acute kidney injury (AKI) and acute myocardial infarction (AMI), and the association between estimated glomerular filtration rate (eGFR) at admission and AKI outcome. Methods: AKI was defined as an increase in serum creatinine (SCr) by !0.3 mg/dl within 48 h or an increase in SCr to !1.5 times baseline within the first 7 days of hospitalization. Patients with AMI were divided into subgroups according to their eGFR at admission and the development of AKI. Results: This study enrolled 396 patients with AMI; 48 (12.1%) developed AKI. In-hospital mortality was 39.6% (19/48) for patients with AKI compared with 7.5% (26/348) in those without AKI (odds ratio [OR] 8.11; 95% confidence interval [CI] 4.02, 16.39). The mortality rate was 35.7% (five of 14) in the eGFR ! 60 ml/min/1.73m 2 with AKI group (OR 6.21, 95% CI 1.50, 25.69) and 41.2% (14/34) in the eGFR < 60 ml/min/1.73m 2 with AKI group (OR 12.62, 95% CI 5.54, 28.74). Conclusions: AKI development was common and associated with mortality in AMI patients with either preserved or impaired eGFR levels.

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Section: Rate Of Aki N (%)mentioning

confidence: 70%

Section: Rate Of Aki N (%)mentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

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Renal function, acute kidney injury and hospital mortality in patients with acute myocardial infarction

et al. 2014

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“…These modifications were based on the accumulating evidence that small increases in serum creatinine are associated with adverse outcomes, and on the variability inherent in commencing renal replacement therapy among different populations and countries. Although some trials evaluated the incidence of AKI defined by either RIFLE [14,15] or AKIN [16,17] in AMI patients, there are no data comparing the RIFLE and AKIN criteria for the diagnosis of AKI after AMI.…”

Section: Discussionmentioning

confidence: 99%

“…More recently, the AKI network (AKIN) [13] proposed refinements to the RIFLE criteria in order to increase sensitivity, using a smaller change in serum creatinine (>0.3 mg/dl) to define the presence of stage I AKI (Table 1). Although some trials evaluated the incidence of AKI defined by either RIFLE or AKIN following AMI [14][15][16][17], it is currently unknown whether discernible advantages exist with one approach over the other to diagnose AKI among these patients. In the present study, we evaluated the incidence as well as short-and long-term mortality associated with AKI using the two different classification systems, and the utilization of both AKIN and RIFLE criteria in a large single-center cohort of consecutive ST elevation myocardial infarction (STEMI) patients.…”

Section: Introductionmentioning

confidence: 99%

Incidence and mortality of acute kidney injury in acute myocardial infarction patients: a comparison between AKIN and RIFLE criteria

et al. 2014

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Relation of In‐hospital Serum Creatinine Change Patterns and Outcomes Among ST‐Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention

Shacham

Leshem

Gal‐Oz

et al. 2015

Clinical Cardiology

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Background: The worsening of serum creatinine (sCr) level is a frequent finding among ST-segment elevation MI (STEMI) patients undergoing primary percutaneous coronary intervention (PCI), associated with adverse short-term and long-term outcomes. No information is present, however, regarding the incidence and prognostic implications associated with an improvement in sCr levels throughout hospitalization, as compared with admission levels. Hypothesis: Reversible renal impairment prior to PCI is not associated with adverse outcomes. Methods: We retrospectively studied 1260 STEMI patients undergoing primary PCI. The incidence of in-hospital complications and long-term mortality was compared between patients having stable, worsened (>0.3 mg/dL increase), or improved (>0.3 mg/dL decrease) sCr levels throughout hospitalization. Results: Overall, 127 patients (10%) had worsening in sCr levels, whereas 44 (3.5%) had an improvement of sCr compared with admission levels. Patients with worsening sCR had more complications during hospitalization, higher 30-day (13% vs 1%; P < 0.001) and up to 5-year all-cause mortality (28% vs 5%; P < 0.001) compared with those with stable sCR. No significant difference was found regarding complications and mortality between patients having an improvement in sCr and stable sCr. Compared with patients with stable sCr, the adjusted hazard ratio for all-cause mortality in patients with worsened sCr was 6.68 (95% confidence interval: 2.1-21.6, P = 0.002). Conclusions: In STEMI patients undergoing primary PCI, renal impairment prior to PCI is a frequent finding. In contrast to post-PCI sCr worsening, this entity is not associated with adverse short-term and long-term outcomes.

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Different clinical outcomes of acute kidney injury according to acute kidney injury network criteria in patients between ST elevation and non-ST elevation myocardial infarction

Cited by 23 publications

References 9 publications

Renal function, acute kidney injury and hospital mortality in patients with acute myocardial infarction

Renal function, acute kidney injury and hospital mortality in patients with acute myocardial infarction

Incidence and mortality of acute kidney injury in acute myocardial infarction patients: a comparison between AKIN and RIFLE criteria

Relation of In‐hospital Serum Creatinine Change Patterns and Outcomes Among ST‐Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention

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