Different classes of antibiotics given to women routinely for preventing infection at caesarean section

Abstract

classes of antibiotics given to women routinely for preventing infection at caesarean section.

Efficacy of adjunctive azithromycin versus single-dose cephalosporin prophylaxis for caesarean scar defect: study protocol for a randomised controlled trial

“…Our previously published data first revealed a CSD prevalence of 43.4% (95% CI 39.1% to 47.7%, n=514) in Shanghai, which is a cause for concern 17. Our cohort study also showed that infection might be an important risk factor for CSD and that multidose antibiotic administration has a significant protective effect compared with single-dose antibiotic administration (CSD prevalence 31.1%, 95% CI 23.8% to 38.3% vs 49.0%, 95% CI 43.8% to 54.3%; aOR=0.4, 95% CI 0.3 to 0.7) 18–20. Furthermore, the single-dose cefuroxime subgroup (n=190) was found to have a significantly lower CSD prevalence than the single-dose cefradine subgroup (n=162) (38.9%, 95% CI 34.7% to 48.6% vs 56.8%, 95% CI 51.3% to 66.7%; aOR=0.5, 95% CI 0.3 to 0.8, p=0.006).…”

Efficacy of adjunctive azithromycin versus single-dose cephalosporin prophylaxis for caesarean scar defect: study protocol for a randomised controlled trial

“…Our previously published data first revealed a CSD prevalence of 43.4% (95% CI 39.1% to 47.7%, n=514) in Shanghai, which is a cause for concern 17. Our cohort study also showed that infection might be an important risk factor for CSD and that multidose antibiotic administration has a significant protective effect compared with single-dose antibiotic administration (CSD prevalence 31.1%, 95% CI 23.8% to 38.3% vs 49.0%, 95% CI 43.8% to 54.3%; aOR=0.4, 95% CI 0.3 to 0.7) 18–20. Furthermore, the single-dose cefuroxime subgroup (n=190) was found to have a significantly lower CSD prevalence than the single-dose cefradine subgroup (n=162) (38.9%, 95% CI 34.7% to 48.6% vs 56.8%, 95% CI 51.3% to 66.7%; aOR=0.5, 95% CI 0.3 to 0.8, p=0.006).…”

Antimicrobial Prophylaxis for Caesarean Delivery; A comparative study between different agents

“…No cases of serious infectious complications were reported. There was no clear difference between groups in maternal length of hospital stay and readmissions to hospital 21,22,30 .…”

“…Three small studies compared the Lincosamide plus aminoglycoside versus Penicillin (1 study, 88 women), and 2 studies (118 women) compared the beta-lactam antibiotics versus cephalosporins. There were no significant differences between groups about postpartum endomyometritis, wound infection, maternal sepsis or postpartum febrile morbidity 22,30 .…”

“…One study (72 women) compared ciprofloxacin receiving versus Ampicillin/ Sulbactam and another trial (81 women) compared ciprofloxacin to cefotetan. There were no clear differences between groups regarding postpartum endomyometritis, wound infection, postpartum morbidity due to fever or severe infectious complications 21,22 .…”

Best practice perioperative strategies and surgical techniques for preventing caesarean section surgical site infections: a systematic review of reviews and meta‐analyses

“…Seventeen studies evaluated three different aspects of antibiotic prophylaxis: timing, antibiotic class and route of administration. The effectiveness of 22 different combinations of antibiotic classes was reported across one meta‐analysis and one systematic review . Similarly, multiple intervention comparator pairs were also evaluated for skin incision, uterine closure, peritoneum closure, wound drainage and skin closure (see Supporting Information Appendix S4).…”

Efficacy of adjunctive azithromycin versus single-dose cephalosporin prophylaxis for caesarean scar defect: study protocol for a randomised controlled trial

“…Our previously published data first revealed a CSD prevalence of 43.4% (95% CI 39.1% to 47.7%, n=514) in Shanghai, which is a cause for concern 17. Our cohort study also showed that infection might be an important risk factor for CSD and that multidose antibiotic administration has a significant protective effect compared with single-dose antibiotic administration (CSD prevalence 31.1%, 95% CI 23.8% to 38.3% vs 49.0%, 95% CI 43.8% to 54.3%; aOR=0.4, 95% CI 0.3 to 0.7) 18–20. Furthermore, the single-dose cefuroxime subgroup (n=190) was found to have a significantly lower CSD prevalence than the single-dose cefradine subgroup (n=162) (38.9%, 95% CI 34.7% to 48.6% vs 56.8%, 95% CI 51.3% to 66.7%; aOR=0.5, 95% CI 0.3 to 0.8, p=0.006).…”

Antimicrobial Prophylaxis for Caesarean Delivery; A comparative study between different agents

“…No cases of serious infectious complications were reported. There was no clear difference between groups in maternal length of hospital stay and readmissions to hospital 21,22,30 .…”

“…Three small studies compared the Lincosamide plus aminoglycoside versus Penicillin (1 study, 88 women), and 2 studies (118 women) compared the beta-lactam antibiotics versus cephalosporins. There were no significant differences between groups about postpartum endomyometritis, wound infection, maternal sepsis or postpartum febrile morbidity 22,30 .…”

“…One study (72 women) compared ciprofloxacin receiving versus Ampicillin/ Sulbactam and another trial (81 women) compared ciprofloxacin to cefotetan. There were no clear differences between groups regarding postpartum endomyometritis, wound infection, postpartum morbidity due to fever or severe infectious complications 21,22 .…”

Best practice perioperative strategies and surgical techniques for preventing caesarean section surgical site infections: a systematic review of reviews and meta‐analyses

“…Seventeen studies evaluated three different aspects of antibiotic prophylaxis: timing, antibiotic class and route of administration. The effectiveness of 22 different combinations of antibiotic classes was reported across one meta‐analysis and one systematic review . Similarly, multiple intervention comparator pairs were also evaluated for skin incision, uterine closure, peritoneum closure, wound drainage and skin closure (see Supporting Information Appendix S4).…”

Efficacy of adjunctive azithromycin versus single-dose cephalosporin prophylaxis for caesarean scar defect: study protocol for a randomised controlled trial

“…Our previously published data first revealed a CSD prevalence of 43.4% (95% CI 39.1% to 47.7%, n=514) in Shanghai, which is a cause for concern 17. Our cohort study also showed that infection might be an important risk factor for CSD and that multidose antibiotic administration has a significant protective effect compared with single-dose antibiotic administration (CSD prevalence 31.1%, 95% CI 23.8% to 38.3% vs 49.0%, 95% CI 43.8% to 54.3%; aOR=0.4, 95% CI 0.3 to 0.7) 18–20. Furthermore, the single-dose cefuroxime subgroup (n=190) was found to have a significantly lower CSD prevalence than the single-dose cefradine subgroup (n=162) (38.9%, 95% CI 34.7% to 48.6% vs 56.8%, 95% CI 51.3% to 66.7%; aOR=0.5, 95% CI 0.3 to 0.8, p=0.006).…”

Antimicrobial Prophylaxis for Caesarean Delivery; A comparative study between different agents

“…No cases of serious infectious complications were reported. There was no clear difference between groups in maternal length of hospital stay and readmissions to hospital 21,22,30 .…”

“…Three small studies compared the Lincosamide plus aminoglycoside versus Penicillin (1 study, 88 women), and 2 studies (118 women) compared the beta-lactam antibiotics versus cephalosporins. There were no significant differences between groups about postpartum endomyometritis, wound infection, maternal sepsis or postpartum febrile morbidity 22,30 .…”

“…One study (72 women) compared ciprofloxacin receiving versus Ampicillin/ Sulbactam and another trial (81 women) compared ciprofloxacin to cefotetan. There were no clear differences between groups regarding postpartum endomyometritis, wound infection, postpartum morbidity due to fever or severe infectious complications 21,22 .…”

Best practice perioperative strategies and surgical techniques for preventing caesarean section surgical site infections: a systematic review of reviews and meta‐analyses

“…Seventeen studies evaluated three different aspects of antibiotic prophylaxis: timing, antibiotic class and route of administration. The effectiveness of 22 different combinations of antibiotic classes was reported across one meta‐analysis and one systematic review . Similarly, multiple intervention comparator pairs were also evaluated for skin incision, uterine closure, peritoneum closure, wound drainage and skin closure (see Supporting Information Appendix S4).…”