Different classes of antibiotics given to women routinely for preventing infection at caesarean section

Abstract

classes of antibiotics given to women routinely for preventing infection at caesarean section.

Puerperal sepsis in the 21st century: progress, new challenges and the situation worldwide

“…Two large groups of antibiotics are commonly used as antibiotic prophylaxis during caesarean section, cephalosporins and penicillins. Current evidence does not show that one of the antibiotic agents is superior to the other in reducing the risk of infection post caesarean section 18. A study from Denmark found that within 30 days post partum, 7.6% of women who had a caesarean section and 1.6% of women after vaginal birth acquired an infection, yielding an almost fivefold increase in the risk for infection after a caesarean section compared with a vaginal birth 19.…”

Best practice perioperative strategies and surgical techniques for preventing caesarean section surgical site infections: a systematic review of reviews and meta‐analyses

“…Seventeen studies evaluated three different aspects of antibiotic prophylaxis: timing, antibiotic class and route of administration. The effectiveness of 22 different combinations of antibiotic classes was reported across one meta‐analysis and one systematic review . Similarly, multiple intervention comparator pairs were also evaluated for skin incision, uterine closure, peritoneum closure, wound drainage and skin closure (see Supporting Information Appendix S4).…”

“…Furthermore, SSI is not always a primary outcome and publications need to be read in depth to identify the impact of each strategy on SSI. A systematic review published in 2013 that examined a range of interventions quickly became outdated due to new evidence . In a more recent systematic review the authors did not make clear recommendations for clinical practice, and the quality of a third review is questionable because its methods are not clear.…”

Prevention of septic complications in obstetrics: The guidelines of the Ministry of Health of the Russian Federation and the World Health Organization 2015

“…В Кохрановском систематическом обзоре 2014 г. (31 исследование, 7697 женщин) не получено убедительных доказательств того, что какой-то класс антибиотиков более эффективен для профилактики инфекционных осложнений при кесаревом сечении [33]. Согласно мнению экспертов ВОЗ, цефалоспорины первого поколения и пе-нициллин имеют преимущество перед другими классами антибиотиков в отношении стоимости и широкой доступности для клинической практики [9].…”