Different circulating metalloproteinases profiles in women with migraine with and without aura

Martins-Oliveira, Alisson; Speciali, José Geraldo; Dach, Fabíola; Marcaccini, Andrea M.; Gonçalves, Flavia M.; Gerlach, Raquel Fernanda; Tanus‐Santos, José Eduardo

doi:10.1016/j.cca.2009.07.008

Cited by 40 publications

(24 citation statements)

References 39 publications

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“…Our results are in part in contrast to a study of Martins‐Oliveira et al. [10] who describe elevated pro‐MMP‐2 and MMP‐2/TIMP‐2 levels in female migraineurs, as well as increased TIMP‐1 and decreased MMP‐9/TIMP‐1 levels in female patients with MwA compared to controls. The differences between the study of Martins‐Oliveira et al.…”

Section: Discussioncontrasting

confidence: 99%

Increased matrix metalloproteinase activity is associated with migraine and migraine-related metabolic dysfunctions

Bernecker¹,

Pailer²,

Kieslinger³

et al. 2010

European Journal of Neurology

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Section: Discussioncontrasting

confidence: 99%

Increased matrix metalloproteinase activity is associated with migraine and migraine-related metabolic dysfunctions

Bernecker¹,

Pailer²,

Kieslinger³

et al. 2010

European Journal of Neurology

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“…Our findings reported here show increased MMP-9 levels in patients with MWA compared to patients with MA, and these findings are very similar to those previously shown in a smaller study (Martins-Oliveira et al, 2009). Interestingly, we found that MA patients, but not MWA patients, had lower MMP-9 and higher TIMP-1 concentrations than healthy controls, thus suggesting that higher TIMP-1 levels could be associated with MMP-9 plasma reduction in MA patients, although we have not determined the mechanisms possibly involved in these differences.…”

Section: Discussionsupporting

confidence: 95%

“…Indeed, experimental studies with MMP-9 knockout mice showed reduced BBB leakage and edema formation (Asahi et al, 2001), thus strongly indicating that MMP-9 is very important for this process. Moreover, previous studies showed increased circulating MMP-9 levels in migraine patients (Leira et al, 2007;Imamura et al, 2008), and it is possible that circulating MMP-9 levels may reflect migraine attacks (Leira et al, 2007;Imamura et al, 2008;Martins-Oliveira et al, 2009). However, it is not known whether genetic variations in the MMP-9 gene may affect the susceptibility to migraine and whether there are subgroups of patients that are genetically exposed to increased MMP-9 levels as a result of genetic differences.…”

Section: Introductionmentioning

confidence: 93%

Specific matrix metalloproteinase 9 (MMP-9) haplotype affect the circulating MMP-9 levels in women with migraine

Martins-Oliveira

Gonçalves

Speciali

et al. 2012

Journal of Neuroimmunology

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We investigated whether three relevant polymorphisms (C-1562T, microsatellite -90(CA)(14-24), and Q279R) in the MMP-9 gene, or MMP-9 haplotypes, are associated with migraine and affect MMP-9 and tissue inhibitor of MMPs (TIMP)-1 levels in patients with migraine. We studied 102 healthy women (controls) and 187 women with migraine (141 without aura - MWA, and 46 with aura - MA). Patients with MWA had higher plasma MMP-9 concentrations than patients with MA. Patients with MA had the highest TIMP-1 and lowest MMP-9/TIMP-1 ratios. The MMP-9 "C L Q" haplotype was associated with higher plasma MMP-9 concentrations in migraine patients.

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“…Furthermore, increases in plasma levels of matrix MMPs (especially MMP-9 and MMP-2) in migraine patients, in the headache phase, suggest a potential pathogenic role for MMP elevation in both migraine attacks and WMLs [132-135]. Different circulating MMP profiles in MwA and migraine without aura (MwoA) may reflect pathophysiological differences between these conditions.…”

Section: Reviewmentioning

confidence: 99%

Cortical spreading depression as a target for anti-migraine agents

et al. 2013

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Spreading depression (SD) is a slowly propagating wave of neuronal and glial depolarization lasting a few minutes, that can develop within the cerebral cortex or other brain areas after electrical, mechanical or chemical depolarizing stimulations. Cortical SD (CSD) is considered the neurophysiological correlate of migraine aura. It is characterized by massive increases in both extracellular K+ and glutamate, as well as rises in intracellular Na+ and Ca2+. These ionic shifts produce slow direct current (DC) potential shifts that can be recorded extracellularly. Moreover, CSD is associated with changes in cortical parenchymal blood flow.CSD has been shown to be a common therapeutic target for currently prescribed migraine prophylactic drugs. Yet, no effects have been observed for the antiepileptic drugs carbamazepine and oxcarbazepine, consistent with their lack of efficacy on migraine. Some molecules of interest for migraine have been tested for their effect on CSD. Specifically, blocking CSD may play an enabling role for novel benzopyran derivative tonabersat in preventing migraine with aura. Additionally, calcitonin gene-related peptide (CGRP) antagonists have been recently reported to inhibit CSD, suggesting the contribution of CGRP receptor activation to the initiation and maintenance of CSD not only at the classic vascular sites, but also at a central neuronal level. Understanding what may be lying behind this contribution, would add further insights into the mechanisms of actions for “gepants”, which may be pivotal for the effectiveness of these drugs as anti-migraine agents.CSD models are useful tools for testing current and novel prophylactic drugs, providing knowledge on mechanisms of action relevant for migraine.

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Different circulating metalloproteinases profiles in women with migraine with and without aura

Abstract: We showed an increased net MMP-2 activity in MWA and MA. The increased MMP-9/TIMP-1 ratios in MWA patients contrast with the lower MMP-9/TIMP-1 ratios in MA patients and may reflect pathophysiological differences between these conditions.

Cited by 40 publications

References 39 publications

Increased matrix metalloproteinase activity is associated with migraine and migraine-related metabolic dysfunctions

Increased matrix metalloproteinase activity is associated with migraine and migraine-related metabolic dysfunctions

Specific matrix metalloproteinase 9 (MMP-9) haplotype affect the circulating MMP-9 levels in women with migraine

Cortical spreading depression as a target for anti-migraine agents

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