Different Characteristics in Gut Microbiome between Advanced Adenoma Patients and Colorectal Cancer Patients by Metagenomic Analysis

Han, Shuwen; Jing, Zhuang; Pan, Yuefen; Wu, Wei; Ding, Kefeng

doi:10.1128/spectrum.01593-22

Cited by 11 publications

(7 citation statements)

References 36 publications

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“…and Oscillibacter spp. are decreased in colorectal cancer and inflammatory bowel disease (IBD) owing to the gut [ [37] , [38] , [39] , [40] ]. Hence, the lung microbiome alterations found in this study suggest the destruction of the mucin layer and inflammation in the lungs.…”

Section: Discussionmentioning

confidence: 99%

Lung cancer progression alters lung and gut microbiomes and lipid metabolism

Hagihara,

Kato,

Yamashita

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Lung cancer progression alters lung and gut microbiomes and lipid metabolism

Hagihara,

Kato,

Yamashita

et al. 2024

Heliyon

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“…Several studies have reported reduced levels of Blautia spp. in the fecal microbiome of CRC patients compared to healthy controls [ 66 , 67 , 68 ]. Wang et al reported a decrease in the abundance of Lachnoclostridium sp.…”

Section: Discussionmentioning

confidence: 99%

Basal Diet Fed to Recipient Mice Was the Driving Factor for Colitis and Colon Tumorigenesis, despite Fecal Microbiota Transfer from Mice with Severe or Mild Disease

et al. 2023

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Consumption of the total Western diet (TWD) in mice has been shown to increase gut inflammation, promote colon tumorigenesis, and alter fecal microbiome composition when compared to mice fed a healthy diet, i.e., AIN93G (AIN). However, it is unclear whether the gut microbiome contributes directly to colitis-associated CRC in this model. The objective of this study was to determine whether dynamic fecal microbiota transfer (FMT) from donor mice fed either the AIN basal diet or the TWD would alter colitis symptoms or colitis-associated CRC in recipient mice, which were fed either the AIN diet or the TWD, using a 2 × 2 factorial experiment design. Time-matched FMT from the donor mice fed the TWD did not significantly enhance symptoms of colitis, colon epithelial inflammation, mucosal injury, or colon tumor burden in the recipient mice fed the AIN diet. Conversely, FMT from the AIN-fed donors did not impart a protective effect on the recipient mice fed the TWD. Likewise, the composition of fecal microbiomes of the recipient mice was also affected to a much greater extent by the diet they consumed than by the source of FMT. In summary, FMT from the donor mice fed either basal diet with differing colitis or tumor outcomes did not shift colitis symptoms or colon tumorigenesis in the recipient mice, regardless of the basal diet they consumed. These observations suggest that the gut microbiome may not contribute directly to the development of disease in this animal model.

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“…It is worth noting that Blastocystis and Entamoeba were significantly positively correlated with various methanogenic archaea. The possible use of methanogens as probiotics has received particular attention in humans [ 40 , 41 ]; therefore, the positive relationship between Blastocystis , Entamoeba , and methanogenic archaea may be beneficial for gut health. The relationship between archaea and parasites in animals has received little attention, and more research is needed to uncover this phenomenon.…”

Section: Discussionmentioning

confidence: 99%

Metagenomic analysis reveals the relationship between intestinal protozoan parasites and the intestinal microecological balance in calves

Fu,

Zhang,

Yang

et al. 2023

Parasites Vectors

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Background A close connection between a protozoan parasite and the balance of the other gut microbes of the host has been demonstrated. The calves may be naturally co-infected with many parasites, and the co-effects of parasites on other intestinal microbes of calves remain unclear. This study aims to preliminarily reveal the relationship between intestinal parasites and other intestinal microbes in calves. Methods Fecal samples were collected from four calves with bloody diarrhea, four calves with watery diarrhea, and seven normal calves, and the microbial flora of the samples were analyzed by whole-genome sequencing. Protozoal parasites were detected in the metagenome sequences and identified using polymerase chain reaction (PCR). Results Cryptosporidium, Eimeria, Giardia, Blastocystis, and Entamoeba were detected by metagenomic analysis, and the identified species were Giardia duodenalis assemblage E, Cryptosporidium bovis, Cryptosporidium ryanae, Eimeria bovis, Eimeria subspherica, Entamoeba bovis, and Blastocystis ST2 and ST10. Metagenomic analysis showed that the intestinal microbes of calves with diarrhea were disordered, especially in calves with bloody diarrhea. Furthermore, different parasites show distinct relationships with the intestinal microecology. Cryptosporidium, Eimeria, and Giardia were negatively correlated with various intestinal bacteria but positively correlated with some fungi. However, Blastocystis and Entamoeba were positively associated with other gut microbes. Twenty-seven biomarkers not only were significantly enriched in bloody diarrhea, watery diarrhea, and normal calves but were also associated with Eimeria, Cryptosporidium, and Giardia. Only Eimeria showed a distinct relationship with seven genera of bacteria, which were significantly enriched in the healthy calves. All 18 genera of fungi were positively correlated with Cryptosporidium, Eimeria, and Giardia, which were also significantly enriched in calves with bloody diarrhea. Functional genes related to parasites and diseases were found mainly in fungi. Conclusions This study revealed the relationship between intestinal protozoan parasites and the other calf gut microbiome. Different intestinal protozoan parasites have diametrically opposite effects on other gut microecology, which not only affects bacteria in the gut, but also is significantly related to fungi and archaea. Graphical Abstract

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Different Characteristics in Gut Microbiome between Advanced Adenoma Patients and Colorectal Cancer Patients by Metagenomic Analysis

Cited by 11 publications

References 36 publications

Lung cancer progression alters lung and gut microbiomes and lipid metabolism

Lung cancer progression alters lung and gut microbiomes and lipid metabolism

Basal Diet Fed to Recipient Mice Was the Driving Factor for Colitis and Colon Tumorigenesis, despite Fecal Microbiota Transfer from Mice with Severe or Mild Disease

Metagenomic analysis reveals the relationship between intestinal protozoan parasites and the intestinal microecological balance in calves

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