Different Cerebral Responses to Puncturing at ST36 among Patients with Functional Dyspepsia and Healthy Subjects

Li, Zhengjie; Zeng, Fang; Yang, Yue; Yuan, Chen; Sun, Jinbo; Qin, Wei; Yang, Jie; Liang, Fanrong

doi:10.1159/000360804

Cited by 14 publications

(8 citation statements)

References 33 publications

(29 reference statements)

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“…All articles [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] were published between 2007 and October 2015 (Table 1). We distinguished two research groups (Group 1: Studies 1, 3, 4; Group 2: Studies 2, 5-16), on the basis of authors and affiliations.…”

Section: Study Selection and Descriptionmentioning

confidence: 99%

Functional neuroimaging studies in functional dyspepsia patients: a systematic review

Lee

Wang

Chae

et al. 2016

Neurogastroenterology Motil

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This systematic review aims to provide an integrative understanding of the abnormal functional brain activity, visceral sensation, dyspeptic symptoms, and psychological changes of FD. Electronic and hand searches were conducted to identify functional neuroimaging studies involving FD patients. Sixteen studies were selected and divided into three categories: 10 resting state studies, three visceral distention studies, and three acupuncture studies. Changes were reported in several brain areas in FD patients including the frontal cortex, somatosensory cortex, insula, anterior cingulate cortex, thalamus, hippocampus, and amygdala. These brain activity changes were associated with visceral hypersensitivity, dyspeptic symptoms, poorer quality of life, anxiety, and depression. The results show that FD is associated with functional abnormalities in sensory and pain modulation, emotion, saliency, and homeostatic processing regions. The diversity of conditions, heterogeneous results, poorly standardized diagnoses of FD, and various comorbidities may be responsible for the variability in the results.

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Section: Study Selection and Descriptionmentioning

confidence: 99%

Functional neuroimaging studies in functional dyspepsia patients: a systematic review

Lee

Wang

Chae

et al. 2016

Neurogastroenterology Motil

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“…Moreover, studies performed on individuals with FD [24], IBS [51], functional diarrhea [25], Crohn’s disease [52], and healthy controls [53] have found that having influence on the brain activity might be an important reason for modulating effects of acupuncture on gastrointestinal function. For example, our previous study [54] demonstrated that puncturing at ST36 could evoke homeostatic afferent processing network of FD patients, which was confirmed as a pivotal network of acupuncture treating for FD in another study [24]. Therefore, we hypothesize that acupuncture could treat FC through normalizing the pathological alteration of the brain activity.…”

Section: Discussionmentioning

confidence: 68%

Effect and cerebral mechanism of acupuncture treatment for functional constipation: study protocol for a randomized controlled clinical trial

Yin

et al. 2019

Trials

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Background Acupuncture is effective in functional constipation (FC) treatment, but the central mechanism has not been well investigated. This trial will combine functional magnetic resonance imaging (fMRI) and positron emission tomography-computed tomography (PET-CT) to investigate the potential central mechanism of acupuncture treatment for FC. Methods This is a multimodal neuroimaging randomized controlled trial. In total, 140 FC patients will be randomly allocated into four groups: the verum acupuncture group; the sham acupuncture group; the PEG 4000 group; and the waiting-list group. This trial will include a two-week baseline period and a two-week treatment period. Patients will receive 10 sessions of acupuncture, sham acupuncture, PEG 4000, or no intervention during the treatment period. The stool diary, Cleveland Constipation Score (CCS), Patient Assessment of Constipation Symptom (PAC-SYM), and Patient Assessment of Constipation Quality of Life Questionnaire (PAC-QoL) will be used to assess the clinical efficacy of different interventions. The MRI and PET-CT scans will be performed to detect cerebral functional changes in 15 patients in each group at baseline and at the end of treatment/waiting. Multimodal imaging data will be associated with clinical data to investigate possible correlation between brain activity changes elicited by different interventions and symptoms improvement. Discussion We hypothesize that acupuncture can treat FC through normalizing the pathological alteration of the cerebral activity. The results of this trial will allow us to re-testify the therapeutic effects of acupuncture treating for FC and to investigate the potential central mechanism of acupuncture treatment for FC from direct (cerebral glucose metabolism) and indirect (contrast of oxyhemoglobin and deoxyhemoglobin) approaches. Trial registration Chinese Clinical Trial Registry, ChiCTR1800016658 . Registered on 14 June 2018. Electronic supplementary material The online version of this article (10.1186/s13063-019-3410-8) contains supplementary material, which is available to authorized users.

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“…In this way, it improves the symptoms of FD, with an effective rate of up to 97%. (2) Imaging mechanism: One RCT showed that compared to healthy subjects, acupuncture stimulation at ST36 with fMRI technique evoked pronounced changes in the homeostatic afferent processing network of FD patients [87]. Fang et al [88] found that acupuncture relieved gastrointestinal symptoms and signs using resting-state fMRI, which may be due to the normalization of brain-gut axis in FD patients.…”

Section: Discussionmentioning

confidence: 99%

Efficacy Comparison of Different Acupuncture Treatments for Functional Dyspepsia: A Systematic Review with Network Meta‐Analysis

Zhang

Liu

Huang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Acupuncture has been found to be an effective treatment for functional dyspepsia (FD). Currently, several types of acupuncture have been developed but it is not clear which type is suitable for FD. Currently, doctors often rely on experience to decide which form of acupuncture to apply. Herein, we employed network meta-analysis (NMA) to compare the effectiveness of various methods of acupuncture in the treatment of functional dyspepsia. Methods. We searched for randomized controlled trials (RCTs) of acupuncture treatments for functional dyspepsia in seven databases; PubMed, the Cochrane Library, Embase, Wanfang database, China National Knowledge Infrastructure (CNKI) database, Chinese Science and Technique Journals (CQVIP), and Chinese Biomedical Database (CBM) from the date of database inception to October 10, 2019. Cochrane risk of bias tool was used to analyze the risk of bias of the included RCTs. Pairwise meta-analyses were performed with RevMan 5.3 and the network metaanalysis of the included RCTs was performed using the frequentist framework. Results. A total of 35 studies involving 3301 patients and 10 interventions were eligible for this study. NMA results showed that five types of acupuncture (manual acupuncture, acupoint application, moxibustion, acupoint catgut embedding, and warm acupuncture alone) all were superior to prokinetics (itopride, mosapride, and domperidone) and sham acupuncture in terms of improving the symptoms of functional dyspepsia. Specifically, manual acupuncture and electroacupuncture were more effective in improving the MOS 36 Item Short-Form Health Survey (SF-36) compared to itopride and sham acupuncture, and electroacupuncture was the best among the three acupuncture therapies (acupuncture, electroacupuncture, and acupoint catgut embedding). Moxibustion and manual acupuncture were more effective in improving Nepean Dyspepsia Life Quality Index (NDLQI) compared to itopride, domperidone, and sham acupuncture; moxibustion ranks first among the three acupuncture therapies (acupuncture, electroacupuncture, moxibustion). Conclusions. ese results showed that manual acupuncture alone was the most effective therapy for FD. It should, therefore, be considered as an alternative treatment for FD patients who are unresponsive to prokinetics or intolerant to the adverse effects of prokinetics. We recommend further multiple centers and high-quality RCT studies to confirm the present findings.

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Different Cerebral Responses to Puncturing at ST36 among Patients with Functional Dyspepsia and Healthy Subjects

Cited by 14 publications

References 33 publications

Functional neuroimaging studies in functional dyspepsia patients: a systematic review

Functional neuroimaging studies in functional dyspepsia patients: a systematic review

Effect and cerebral mechanism of acupuncture treatment for functional constipation: study protocol for a randomized controlled clinical trial

Efficacy Comparison of Different Acupuncture Treatments for Functional Dyspepsia: A Systematic Review with Network Meta‐Analysis

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