Different Ca2+ channels in soma and dendrites of hippocampal pyramidal neurons mediate spike-induced Ca2+ influx

Christie, Brian R.; Eliot, Lise; Ito, Kenichi; Miyakawa, Hiroyoshi; Johnston, Daniel

doi:10.1152/jn.1995.73.6.2553

Cited by 204 publications

(140 citation statements)

References 32 publications

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“…Unlike in hippocampal pyramidal neurons (Christie et al, 1995;Magee and Johnston, 1995) the densities and distributions of calcium channel subtypes have not been characterized in L2/3 neurons. We therefore cannot exclude the possibility that distal dendritic channels are more sensitive to predepolarization than those in the proximal dendrite.…”

Section: Discussionmentioning

confidence: 99%

Boosting of Action Potential Backpropagation by Neocortical Network ActivityIn Vivo

Waters¹,

Helmchen²

2004

J. Neurosci.

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Action potentials backpropagate into the dendritic trees of pyramidal neurons, reporting output activity to the sites of synaptic input and provoking long-lasting changes in synaptic strength. It is unclear how this retrograde signal is modified by neural network activity. Using whole-cell recordings from somata, apical trunks, and dendritic tuft branches of layer 2/3 pyramidal neurons in vivo, we show that network-driven subthreshold membrane depolarizations ("up states") occur simultaneously throughout the apical dendritic tree. This spontaneous synaptic activity enhances action potential-evoked calcium influx into the distal apical dendrite by promoting action potential backpropagation. Hence, somatic feedback to the dendrites becomes stronger with increasing network activity.

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Section: Discussionmentioning

confidence: 99%

Boosting of Action Potential Backpropagation by Neocortical Network ActivityIn Vivo

Waters¹,

Helmchen²

2004

J. Neurosci.

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“…An interaction of N-V DCC s with the cytoskeleton is supported by the polarized distribution (Jones et al, 1989;Westenbroek et al, 1992;Mills et al, 1994;Christie et al, 1995) and the immobility of Ͼ70% (Jones et al, 1989) of N-VDCCs in mature hippocampal neurons and by the fact that the first postnatal week is a major phase for maturation of the neuronal cytoskeleton (Burgoyne, 1991).…”

Section: Discussionmentioning

confidence: 99%

“…Second, the efficacy of CA1 synapses is reported to be high [release probability (P r ) close to unity] in very young (P4 -P6) hippocampi but diminishes to a lower level (P r Ͻ0.5) with maturation (Bolshakov and Siegelbaum, 1995). A purely presynaptic role for N-V DCC s is probably unlikely, however, because N-VDCCs also are found on hippocampal dendrites (Jones et al, 1989;Westenbroek et al, 1992;Mills et al, 1994;Christie et al, 1995) and their spines (Mills et al, 1994). Although the functional contribution such postsynaptic N-VDCCs make is unclear (Mills et al, 1994;Elliott et al, 1995), one plausible role is to direct afferent axons to discrete synapses.…”

Section: Discussionmentioning

confidence: 99%

N-Type Calcium Channels in the Developing Rat Hippocampus: Subunit, Complex, and Regional Expression

et al. 1997

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The expression of multiple classes of voltage-dependent calcium channels (VDCCs) allows neurons to tailor calcium signaling to functionally discrete cellular regions. In the developing hippocampus a central issue is whether the expression of VDCC subtypes plays a role in key phases such as migration and synaptogenesis. Using radioligand binding and immunoblotting, we show that some N-type VDCCs exist before birth, consistent with a role in migration; however, most N-VDCC subunit expression is postnatal, coinciding with synaptogenesis. Immunoprecipitation studies indicate that the increased expression of N-VDCCs in early development occurs without subunit switching because there is no change in the fraction of ␤ 3 subunits in the N-VDCC ␣ 1B -␤ 3 heteromers. Fluorescence imaging of cell surface N-VDCCs during this period reveals that N-VDCCs are expressed on somata before dendrites and that this expression is asynchronous between different subfields of the hippocampus (CA3-CA4 before CA1-CA2 and dentate gyrus). Our data argue that N-VDCC expression is an important cue in the genesis of synaptic transmission in discrete hippocampal subfields.

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“…[50][51][52][53] For example, in CA1 pyramidal neurons where Ni 2C dependent synaptic plasticity mechanisms have been described at the Schaffer collateral synapses, 19,39 Ni 2C sensitive channels are more abundant in the distal area of the apical dendrites. 54 Accordingly, by recording field potentials at different locations, "proximal," "middle" and "distal" along the apical dendrite of CA1 pyramidal neurons, Isomura et al 55 showed that while no significant difference among the magnitudes of the induced LTP was observed at these 3 dendritic locations in control condition, Ni 2C strongly inhibited the LTP induction in distal dendrites, slightly in middle dendrites, and did not significantly influenced LTP at proximal dendrites. Thus, for a given synaptic type, the specific T-(R) channel distribution may underlie different induction mechanisms of LTP along a dendrite.…”

Section: Subcellular Localization Of T-type Channels and Synaptic Plamentioning

confidence: 99%

T-type calcium channels in synaptic plasticity

Leresche

Lambert

2016

Channels

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The role of T-type calcium currents is rarely considered in the extensive literature covering the mechanisms of long-term synaptic plasticity. This situation reflects the lack of suitable T-type channel antagonists that till recently has hampered investigations of the functional roles of these channels. However, with the development of new pharmacological and genetic tools, a clear involvement of T-type channels in synaptic plasticity is starting to emerge. Here, we review a number of studies showing that T-type channels participate to numerous homo-and heterosynaptic plasticity mechanisms that involve different molecular partners and both pre-and postsynaptic modifications. The existence of T-channel dependent and independent plasticity at the same synapse strongly suggests a subcellular localization of these channels and their partners that allows specific interactions. Moreover, we illustrate the functional importance of T-channel dependent synaptic plasticity in neocortex and thalamus.

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Different Ca2+ channels in soma and dendrites of hippocampal pyramidal neurons mediate spike-induced Ca2+ influx

Cited by 204 publications

References 32 publications

Boosting of Action Potential Backpropagation by Neocortical Network ActivityIn Vivo

Boosting of Action Potential Backpropagation by Neocortical Network ActivityIn Vivo

N-Type Calcium Channels in the Developing Rat Hippocampus: Subunit, Complex, and Regional Expression

T-type calcium channels in synaptic plasticity

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