Different Biochemical Properties Of House Dust Mite Induce Divergent Epithelial And Inflammatory Responses

Post, S.; Nawijn, Martijn C.; Oosterhout, Antoon van; Heijink, Irene H.

doi:10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1444

Cited by 1 publication

(2 citation statements)

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“…However, the impaired barrier function observed in poorly controlled asthmatics [28] is not replicated following a single dose of HDM to mice in vivo [29] and, therefore, might be a function of chronic as opposed to acute exposure. Alternatively, these differences could reflect the variability of protease activity exhibited by different commercial preparations of extract used by various laboratories [30].…”

Section: Protease Activity Pars and Tight Junctionsmentioning

confidence: 99%

“…However, because the mites consume the egested pellets, these are present in the gut and, therefore, the subsequent preparation. It should be noted that extracts of commercially available HDM vary according to their preparation, resulting in markedly different biochemical properties such as protease activity, exo- and endochitinase levels and endotoxin content [30]. Soluble HDM extract is increasingly being used but a recent study has shown that pathology is worsened when the allergens are administered in particulate form mimicking inhaled airborne particulate matter.…”

Section: Endotoxin and Tlrsmentioning

confidence: 99%

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Orchestrating house dust mite-associated allergy in the lung

Gregory

Lloyd

2011

Trends in Immunology

351

370

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House dust mites (HDM; Dermatophagoides sp.) are one of the commonest aeroallergens worldwide and up to 85% of asthmatics are typically HDM allergic. Allergenicity is associated both with the mites themselves and with ligands derived from mite-associated bacterial and fungal products. Murine models of allergic airways disease for asthma research have recently switched from the use of surrogate allergen ovalbumin together with adjuvant to use of the HDM extract. This has accelerated understanding of how adaptive and innate immunity generate downstream pathology. We review the myriad ways in which HDM allergic responses are orchestrated. Understanding the molecular pathways that elicit HDM-associated pathology is likely to reveal novel targets for therapeutic intervention.

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Section: Protease Activity Pars and Tight Junctionsmentioning

confidence: 99%

Section: Endotoxin and Tlrsmentioning

confidence: 99%