Different behavior of azomethine ylides derived from 11H-indeno[1,2-b]quinoxalin-11-one and proline/sarcosine in reactions with 3-nitro-2H-chromenes

Multifunctional Derivatives of Spiropyrrolidine Tethered Indeno-Quinoxaline Heterocyclic Hybrids as Potent Antimicrobial, Antioxidant and Antidiabetic Agents: Design, Synthesis, In Vitro and In Silico Approaches

“…As shown in Scheme 1 , we have chosen as a model the following four components: ninhydrin 1, o-phenylenediamine 2, sarcosine 3 and ( E )-3-arylidene-1-methylpyrrolidine-2,5-dione 4a (Ar = C6H5) [ 49 , 50 ]. The reaction was carried out at different temperatures in acetonitrile and methanol.…”

“…In the present study, the antimicrobial activity of the synthesized compounds was screened by agar disc diffusion method according to the protocol described by Kadri et al [ 49 ], against four bacteria, namely Staphylococcus aureus ATCC 25923, Micrococccus luteus NCIMB 8166, Escherichia coli ATCC 25,922 and Pseudomonas aeruginosa ATCC 27853. Moreover, it was tested against two fungal strains, namely Candida albicans ATCC 90,028 and Candida krusei ATCC 6258.…”

[3+2] Cycloaddition mediated synthesis of spirooxindole pyrrolidine/piperidine fused chromene aldehyde derivatives: DFT studies, antibacterial evaluation and molecular docking investigation as DNA gyrase inhibitors

“…Previously, there have been several reports on 1,3-dipolar cycloaddition for the synthesis of spiro heterocycles using various chromene derivatives such as nitrochromene and chromene nitrile. [37][38][39][40][41][42][43][44][45][46][47][48][49] But to date, there is not a single report on 1,3-dipolar cycloaddition with chromene aldehyde. Hence, this is the first report of one-pot reaction of 2H-chromene-3carbaldehydes with isatin based azomethine ylides to furnish spiro cycloadducts.…”

Synthesis of 8-oxa-2-azaspiro[4.5]decane

“…Currently, spiro compounds are attracting attention as scaff olds in the search for modern drugs. [2][3][4][5][6][7][8][9] The combination of the intrinsic complexity and, more importantly, the rigidity of these scaff olds off er a number of advantages for programmed drug discovery.…”

“…They are used as an FGFR4 inhibitor for the treatment of hepatocellular carcinoma, 14 as inhibitors of the vanin-1 enzyme, which plays an important role in metabolism and in infl ammation, 15 as 17β-HSD1 inhibi-tors in the treatment or prevention of diseases or disorders associated with steroid hormones or requiring concentration reduction of endogenous estradiol, 16 as NO-independent and heme-dependent sGC stimulants that are useful in the treatment of a variety of diseases. 17,18 At the same time, there were no data on the preparation methods, properties, and spectral characteristics of 8-oxa-2-azaspiro [4.5]decane (5) itself. This work is devoted to the development of the synthesis of spiro compound 5 and to the proof of its structure.…”