Different Auxin Response Machineries Control Distinct Cell Fates in the Early Plant Embryo

Rademacher, Eike H.; Lokerse, Annemarie S.; Schlereth, Alexandra; Llavata-Peris, Cristina I.; Bayer, Martin; Kientz, Marika; Rios, Alejandra Freire; Borst, Jan Willem; Lukowitz, Wolfgang; Jürgens, Gerd; Weijers, Dolf

doi:10.1016/j.devcel.2011.10.026

Cited by 186 publications

(209 citation statements)

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“…A major challenge for auxin biologists is to explain how a small molecule such as IAA can trigger the vast range of intricate, complex, and tissue-specific responses throughout plant development (Paciorek and Friml, 2006;Teale et al, 2006;Benjamins and Scheres, 2008;Vanneste and Friml, 2009;Rademacher et al, 2012;Enders and Strader, 2015;Hagen, 2015). We have recently shown that the atypical auxin response factor ETT responds to changes in cellular auxin levels in a different way from the canonical TIR1-dependent auxin-signaling pathway (Simonini et al, 2016), thus providing an additional route for auxin to mediate its diverse effects.…”

Section: Discussionmentioning

confidence: 99%

“…Auxins comprise a class of plant hormones including the predominant auxin, indole-3-acetic acid (IAA), which is involved in an exceptional range of developmental processes during organ growth and differentiation (Benjamins and Scheres, 2008;Vanneste and Friml, 2009). In the nucleus, high auxin levels cause degradation of the Aux/IAA repressors, allowing auxin response factors (ARFs) to regulate transcription of their target genes in a signaling cascade that culminates in a myriad of different pathways (Vernoux et al, 2011;Rademacher et al, 2012;Calderón-Villalobos et al, 2012;Weijers and Wagner, 2016). The Arabidopsis thaliana genome encodes 23 ARFs and the N-terminal region of each ARF possesses a conserved DNA binding domain (DBD) able to mediate ARF dimerization and recognize auxin response elements (AuxREs) with the general sequence motif TGTCNN.…”

Section: Introductionmentioning

confidence: 99%

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Auxin-Induced Modulation of ETTIN Activity Orchestrates Gene Expression in Arabidopsis

et al. 2017

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The phytohormone auxin governs crucial developmental decisions throughout the plant life cycle. Auxin signaling is effectuated by auxin response factors (ARFs) whose activity is repressed by Aux/IAA proteins under low auxin levels, but relieved from repression when cellular auxin concentrations increase. ARF3/ETTIN (ETT) is a conserved noncanonical Arabidopsis thaliana ARF that adopts an alternative auxin-sensing mode of translating auxin levels into multiple transcriptional outcomes. However, a mechanistic model for how this auxin-dependent modulation of ETT activity regulates gene expression has not yet been elucidated. Here, we take a genome-wide approach to show how ETT controls developmental processes in the Arabidopsis shoot through its auxin-sensing property. Moreover, analysis of direct ETT targets suggests that ETT functions as a central node in coordinating auxin dynamics and plant development and reveals tight feedback regulation at both the transcriptional and protein-interaction levels. Finally, we present an example to demonstrate how auxin sensitivity of ETT-protein interactions can shape the composition of downstream transcriptomes to ensure specific developmental outcomes. These results show that direct effects of auxin on protein factors, such as ETT-TF complexes, comprise an important part of auxin biology and likely contribute to the vast number of biological processes affected by this simple molecule.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Auxin-Induced Modulation of ETTIN Activity Orchestrates Gene Expression in Arabidopsis

et al. 2017

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“…In our previous studies, endogenous auxin, zeatin and ABA were at high levels in highly regenerable rice callus (Liu and Lee 1996;Huang et al 2012). Auxin might be the main factor controlling cell differentiation (Bassuner et al 2007;Petrásek and Friml 2009;Rademacher et al 2012). Our previous studies indicated that endogenous auxin levels in rice calli may play critical roles during shoot regeneration (Huang et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Osmotic stress stimulates shoot organogenesis in callus of rice (Oryza sativa L.) via auxin signaling and carbohydrate metabolism regulation

Lee

Huang

2013

Plant Growth Regul

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This study aimed to clarify the possible mechanism of endogenous phytohormone signaling and carbohydrate metabolism during shoot organogenesis induced by osmotic stress in rice (Oryza sativa L. cv. Tainung 71) callus. Non-regenerable calli derived from Tainung 71 immature embryos were inoculated on Murashige and Skoog medium containing 10 lM 2,4-D. They turned to highly regenerable calli (HRC) (regeneration frequency more than 75 %) with lower calli fresh weight and water content when 0.6 M sorbitol was supplemented into the medium. The regeneration frequency was prominently decreased to 25 % while an auxin transport inhibitor, 2,3,5-triiodobenzoic acid (TIBA), was added into the sorbitoltreated medium. It suggested that endogenous auxin signal may be involved in the induction of HRC under osmotic stress treatment. As well, HRC showed high levels of glucose, sucrose, and starch and high expression of cell wall-bound invertase 1, sucrose transporter 1 (OsSUT1), OsSUT2, PIN-formed 1, and late embryogenesis abundant 1 (OsLEA1) genes. Their expressions are all dramatic inhibited except OsLEA1 under TIBA treatment. It suggests a key role of auxin may be linked to the effect of shoot regeneration under osmotic stress treatment. Therefore, we present a putative hypothesis for regenerable calli induction by osmotic stress treatment in rice. Osmotic stress may regulate endogenous levels of auxin interacting with abscisic acid, then affect carbohydrate metabolism to trigger callus initiation and further shoot regeneration in rice.

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“…Interestingly, the non-cell-autonomous ARF3-mediated down-regulation of DR5::GUS activation in stigma epidermal cells suggests that ARF3 modulates a second auxin response cascade that acts cell-autonomously in these cells. Such interplay between non-cell-autonomous and cell-autonomous auxin response modules has been described in hypophysis specification (25). At present, it is not known if the down-regulation of ARF3 downstream targets and the dampening of a cell-autonomous auxin response cascade in stigma epidermal cells are two separate consequences of ARF3 activity or if suppression of the proposed mobile signal in turn down-regulates the cell-autonomous auxin response in the stigma epidermis.…”

Section: Discussionmentioning

confidence: 95%

Non-cell-autonomous regulation of crucifer self-incompatibility by Auxin Response Factor ARF3

Tantikanjana

Nasrallah

2012

Proc. Natl. Acad. Sci. U.S.A.

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In many angiosperms, outcrossing is enforced by genetic selfincompatibility (SI), which allows cells of the pistil to recognize and specifically inhibit "self" pollen. SI is often associated with increased stigma-anther separation, a morphological trait that promotes crosspollen deposition on the stigma. However, the gene networks responsible for coordinate evolution of these complex outbreeding devices are not known. In self-incompatible members of the Brassicaceae (crucifers), the inhibition of "self"-pollen is triggered within the stigma epidermal cell by allele-specific interaction between two highly polymorphic proteins, the stigma-expressed S-locus receptor kinase (SRK) and its pollen coat-localized ligand, the S-locus cysteinerich (SCR) protein. Using Arabidopsis thaliana plants that express SI as a result of transformation with a functional SRK-SCR gene pair, we identify Auxin Response Factor 3 (ARF3) as a mediator of crosstalk between SI signaling and pistil development. We show that ARF3, a regulator of pistil development that is expressed in the vascular tissue of the style, acts non-cell-autonomously to enhance the SI response and simultaneously down-regulate auxin responses in stigma epidermal cells, likely by regulating a mobile signal derived from the stylar vasculature. The inverse correlation we observed in stigma epidermal cells between the strength of SI and the levels of auxin inferred from activity of the auxin-responsive reporter DR5:: GUS suggests that the dampening of auxin responses in the stigma epidermis promotes inhibition of "self" pollen in crucifer SI.pollen-stigma interaction | receptor signaling | auxin signaling | cell-cell communication F lowering plants having both female and male reproductive structures within the same flower have evolved a variety of mechanisms that promote cross-pollination, thereby allowing them to avoid inbreeding depression and maintain genetic variation among individuals. Among the most recognized outcrossing mechanisms are physiological self-incompatibility (SI) systems, which enable cells of the female reproductive tract to recognize and reject genetically related pollen grains, and morphological adaptations in flower architecture that increase the separation between stigma and anther heights and thus minimize the chance of physical contact between pollen and stigma within a flower (1, 2). Although these physiological and morphological barriers to selfing appear to be unrelated mechanistically, they are often found to coevolve, suggesting that SI and floral developmental programs are based on intersecting genetic networks.Arabidopsis thaliana is a highly self-fertile species that harbors nonfunctional alleles of the two genes that determine specificity in the SI response of the Brassicaceae: SRK, which encodes the S-locus receptor kinase (SRK), a transmembrane protein displayed on the surface of stigma epidermal cells, and SCR, which encodes the Slocus cysteine-rich protein, which is the pollen coat-localized ligand for SRK. In previous studies, we sh...

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Different Auxin Response Machineries Control Distinct Cell Fates in the Early Plant Embryo

Cited by 186 publications

References 51 publications

Auxin-Induced Modulation of ETTIN Activity Orchestrates Gene Expression in Arabidopsis

Auxin-Induced Modulation of ETTIN Activity Orchestrates Gene Expression in Arabidopsis

Osmotic stress stimulates shoot organogenesis in callus of rice (Oryza sativa L.) via auxin signaling and carbohydrate metabolism regulation

Non-cell-autonomous regulation of crucifer self-incompatibility by Auxin Response Factor ARF3

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