Different Antiulcer Activities of Pantoprazole in Stress, Alcohol and Pylorus Ligation-Induced Ulcer Models

Abstract

Antiulcer effects of pantoprazole, a proton-pump inhibitor, on water-immersion restraint stress (WIRS)-, alcohol (ethanol)- and pylorus ligation-induced gastric ulcers were investigated in male rats. Rats were orally administered with pantoprazole 30 min prior to exposure to various types of ulcer inducers. In stress-induced ulcer model, rats were subjected to WIRS at 22℃ for 4 hours, and the degree of ulcer (in mm) was evaluated. In alcohol-induced ulcer model, rats were orally administered with pure (100%) ethanol (1 mL/kg), and the ulcer lesions were measured 1 hour after ethanol challenge. In pylorus ligation-induced ulcer model, rats were subjected to pylorus ligation, and the degree of erosions and ulcers was scored 17 hours after the operation. Pantoprazole attenuated the ulcer lesions induced by WIRS in a dose-dependent manner, exhibiting a median effective dose (ED50) value of 0.78 mg/kg. By comparison, pantoprazole was effective at relatively-high doses for the improvement of ethanol-induced ulcers, showing an ED50 value of 20.5 mg/kg. Notably, pantoprazole was practically ineffective (ED50>50.0) in pylorus ligation model. Taken together, it was confirmed that pantoprazole showed inhibitory activity on gastric ulcers induced by stress and alcohol, but was ineffective on pylorus ligation-induced ulcer. Therefore, the results indicate that proton-pump inhibitors including pantoprazole might reveal highly-different effects according to the type of ulcer inducers, and that the prescription of antiulcer agents should be carefully selected.

<p>Gastroprotective Effect of DLBS2411 Bioactive Fraction from <em>Cinnamomum burmannii</em> Against Ethanol-Induced Gastric Damage in Rats</p>

“…Instead, it was proposed that static and radical reactions in the mucosa are the main cascade for the induction of alcoholic mucosa injury. 3 Gastric mucus, produced in the pit cells of gastric pits, is considered essential for providing protection to the gastric mucosa. Changes in gastric mucus content have been shown to occur in association with the oral administration of ethanol or aspirin.…”

“…The risk factors for gastric ulcer include consumption of non-steroidal antiinflammatory drugs, stress, steroids, infection by Helicobacter pylori, and ethanol consumption. [1][2][3] Furthermore, stress, smoking, and nutritional deficiencies have also been found to increase the incidence of gastric ulcer. 2,3 The pathogenesis of gastric ulcer is believed to be a multifactorial process.…”

“…[1][2][3] Furthermore, stress, smoking, and nutritional deficiencies have also been found to increase the incidence of gastric ulcer. 2,3 The pathogenesis of gastric ulcer is believed to be a multifactorial process. In this process, chronic antral gastritis has been proven to be a major prerequisite in the pathogenesis of gastric and duodenal ulcer in humans.…”

Inhibitory effects of a β-dunnione compound MB12662 on gastric secretion and ulcers

“…Control animals were given the same volume (5 mL/kg) of vehicle (1% carboxymethylcellulose). Thirty minutes later, the rats were orally administered 3 mL/kg of ethanol for the induction of gastric ulcer [8,9]. …”

“…The length of ulcer (hemorrhagic) lesions was measured under a stereomicroscope. Ulcer index was presented as the total length of the lesions [8,9]. …”