Different antibiotic strategies in transient tachypnea of the newborn: an ambispective cohort study

Li, Jinhui; Wu, Jinlin; Du, Lizhong; Hu, Yong; Yang, Xiaoyan; Mu, Dezhi; Xia, Bin

doi:10.1007/s00431-015-2526-4

Cited by 10 publications

(2 citation statements)

References 25 publications

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“…In contrast, Weintraub et al reported no difference in median length of hospital stay between the treated and untreated groups. Similarly, in 2015, Li et al reported no difference between the control and treated groups [17,18].…”

Section: Discussionmentioning

confidence: 92%

Transient Tachypnea of the Newborn and the Use of Prophylactic Antibiotics

Saadoun¹,

Doya²,

Dayoub³

et al. 2021

JDDMC

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Background: Transient tachypnea of the newborn (TTNB) is a common cause of respiratory distress in late preterm and full-term infants. It is caused by a delay in the clearance of fetal lung fluids. Although TTNB is a self-limited condition, prophylactic antibiotics usually administered for 48-72 hours until negative blood culture is reported. Objective: In this study, we aim to identify the relationship between using prophylactic antibiotics and the duration of tachypnea and hospitalization in neonates with TTNB. Materials and Methods: this was a cohort study design included 102 infants with TTNB. The infants were divided into two groups, one received supportive care, and the other received supportive care with intravenous antibiotics. The clinical signs and laboratory results were examined in the two groups. Results: Of total 102 infants who were included in this study, 41 (40.2%) were received supportive care with prophylactic intravenous antibiotics. There were no significant differences between two groups in terms of gender, gestational age, birth weight, mode of delivery, and white blood cell. A significant relation was found between receiving prophylactic antibiotics with the duration of tachypnea and hospitalization. Conclusions: In the recent study, we found an increase in the hospitalization and tachypnea period in the group received antibiotics.

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Section: Discussionmentioning

confidence: 92%

Transient Tachypnea of the Newborn and the Use of Prophylactic Antibiotics

Saadoun¹,

Doya²,

Dayoub³

et al. 2021

JDDMC

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“…Twenty studies were identified that described aspects of guideline implementation or health systems strengthening to improve outcomes of preterm babies in LMICs [ 59 , 63 , 104 , 128 , 130 , 135 , 142 , 144 , 145 , 157 , 177 , 178 , 180 , 181 , 188 , 191 , 197 - 200 ].…”

Section: Resultsmentioning

confidence: 99%

Interventions to reduce preterm birth and stillbirth, and improve outcomes for babies born preterm in low- and middle-income countries: A systematic review

et al. 2021

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Background Reducing preterm birth and stillbirth and improving outcomes for babies born too soon is essential to reduce under-5 mortality globally. In the context of a rapidly evolving evidence base and problems with extrapolating efficacy data from high- to low-income settings, an assessment of the evidence for maternal and newborn interventions specific to low- and middle-income countries (LMICs) is required. Methods A systematic review of the literature was done. We included all studies performed in LMICs since the Every Newborn Action Plan, between 2013 - 2018, which reported on interventions where the outcome assessed was reduction in preterm birth or stillbirth incidence and/or a reduction in preterm infant neonatal mortality. Evidence was categorised according to maternal or neonatal intervention groups and a narrative synthesis conducted. Results 179 studies (147 primary evidence studies and 32 systematic reviews) were identified in 82 LMICs. 81 studies reported on maternal interventions and 98 reported on neonatal interventions. Interventions in pregnant mothers which resulted in significant reductions in preterm birth and stillbirth were (i) multiple micronutrient supplementation and (ii) enhanced quality of antenatal care. Routine antenatal ultrasound in LMICs increased identification of fetal antenatal conditions but did not reduce stillbirth or preterm birth due to the absence of services to manage these diagnoses. Interventions in pre-term neonates which improved their survival included (i) feeding support including probiotics and (ii) thermal regulation. Improved provision of neonatal resuscitation did not improve pre-term mortality rates, highlighting the importance of post-resuscitation care. Community mobilisation, for example through community education packages, was found to be an effective way of delivering interventions. Conclusions Evidence supports the implementation of several low-cost interventions with the potential to deliver reductions in preterm birth and stillbirth and improve outcomes for preterm babies in LMICs. These, however, must be complemented by overall health systems strengthening to be effective. Quality improvement methodology and learning health systems approaches can provide important means of understanding and tackling implementation challenges within local contexts. Further pragmatic efficacy trials of interventions in LMICs are essential, particularly for interventions not previously tested in these contexts.

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Different antibiotic strategies in transient tachypnea of the newborn: an ambispective cohort study

Abstract: • Our combined strategy for TTN can reduce antibiotics usage. • New strategy did not increase the incidence of infection and adverse outcomes.

Cited by 10 publications

References 25 publications

Transient Tachypnea of the Newborn and the Use of Prophylactic Antibiotics

Transient Tachypnea of the Newborn and the Use of Prophylactic Antibiotics

Interventions to reduce preterm birth and stillbirth, and improve outcomes for babies born preterm in low- and middle-income countries: A systematic review

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