Different age-related changes in NMDA and glycine receptors in the rat brain

Araki, Tsutomu; Kato, Harubumi; Shuto, Katsuro; Fujiwara, Takehiko; Itoyama, Yasuto

doi:10.1016/1382-6689(95)00015-1

Cited by 5 publications

(4 citation statements)

References 38 publications

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“…There is debate about the age‐related changes in NMDA receptors and NOS activity. Some investigators reported no significant changes in NMDA binding in the aged rat hippocampus ( Araki et al . 1996 , Shimada et al .…”

Section: Discussionmentioning

confidence: 99%

Deficits in nitric oxide production after tetanic stimulation are related to the reduction of long‐term potentiation in Schaffer‐CA1 synapses in aged Fischer 344 rats

Mori

Togashi

Matsumoto

et al. 2000

Acta Physiologica Scandinavica

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In the present study, we investigated whether nitric oxide (NO) production after tetanic stimulation is involved in long-term potentiation (LTP) in Schaffer-CA1 synapses in both young adult and aged rats. The changes in both the population spike amplitude and NO metabolites, nitrite (NO2-) and nitrate (NO3-), in the CA1 region were simultaneously determined before and after tetanic stimulation. Increases in NOx (NO2- plus NO3-) levels in the CA1 region were observed after tetanic stimulation in young adult rats as well as increase in the population spike amplitude. In aged rats, LTP was significantly inhibited compared with that in young adult rats. No increase in NOx level after tetanic stimulation was observed in aged rats. These findings directly demonstrated that NO production might be involved in the process of LTP formation in Schaffer-CA1 synapses of the rat hippocampus, and that the deficiency of hippocampal NO production might be responsible for reduction of LTP formation in aged rats.

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Section: Discussionmentioning

confidence: 99%

Deficits in nitric oxide production after tetanic stimulation are related to the reduction of long‐term potentiation in Schaffer‐CA1 synapses in aged Fischer 344 rats

Mori

Togashi

Matsumoto

et al. 2000

Acta Physiologica Scandinavica

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“…Sex-based differences in vascular responsiveness were mainly in rats aged 8 -24 wk. Hence, we selected rats aged 8 wk (representing only sexual immaturity) and 14 wk (representing the reproductive period) as representatives in this part of the experiment (2,40). Second, to further clarify whether hormone-replacement treatment can improve cardiovascular function in the elderly (4, 15, 27, 37), 1.5-year rats, even though they also showed no obvious sex-based differences in vascular reactivity as 4-wk-old rats, were chosen as representatives in this part of the experiment.…”

Section: Animal Studiesmentioning

confidence: 99%

“…NORMAL RATS. Male (64) and female (64) immature-to-mature and reproductive-to-aged SpragueDawley (SD) rats (4,8,10,14,18, and 24 wk and 1 and 1.5 years; n ϭ 8 rats/sex/age group), whereby 4 wk represents immature, 8 wk-24 wk represents mature and reproductive age, respectively, and 1 year and 1.5 years represents old age, were used (2,40). On the day of experimentation, rats were anesthetized with pentobarbital sodium (50 mg/kg ip).…”

Section: Animal Studiesmentioning

confidence: 99%

Age and sex differences in vascular responsiveness in healthy and trauma patients: contribution of estrogen receptor-mediated Rho kinase and PKC pathways

Xiao

Zhang

et al. 2014

American Journal of Physiology-Heart and Circulatory Physiology

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L. Age and sex differences in vascular responsiveness in healthy and trauma patients: contribution of estrogen receptor-mediated Rho kinase and PKC pathways. Am J Physiol Heart Circ Physiol 306: H1105-H1115, 2014. First published February 15, 2014 doi:10.1152/ajpheart.00645.2013.-Several medical conditions exhibit age-and sex-based differences. Whether or not traumatic shock exhibits such differences with regard to vascular responsiveness is not clear. In a cohort of 177 healthy subjects and 842 trauma patients (21-82 years) as well as different ages (4,8,10,14,18, and 24 wk; 1 and 1.5 years) and sexes of Sprague-Dawley normal and traumatic shock rats, the age-and sex-based differences of vascular responsiveness and the underlying mechanisms were investigated. Middle-aged and young women as well as female rats of reproductive age had higher vascular responsiveness in the normal condition and a lower decrease in vascular responsiveness after traumatic shock than older men and male rats of identical age. Exogenous supplementation of 17␤-estrdiol increased vascular reactivity in both male and femal rats of 8 -24 wk and preserved vascular responsiveness in rats following traumatic shock. No effect was observed in rats 1 to 1.5 years. These protective effects of estrogen were closely related to G protein-coupled receptor (GPR)30, estrogen receptor-mediated Rho kinase, and PKC pathway activation. Vascular responsiveness exhibits age-and sex-based differences in healthy subjects and trauma patients. Estrogen and its receptor (GPR30) mediated activation of Rho kinase and PKC using genomic and nongenomic mechanisms to elicit protective effects in vascular responsiveness. This finding is important for the personalized treatment for several age-and sex-related diseases involving estrogen. vascular reactivity; sex; age; estrogen; estrogen receptor; Rho kinase; PKC IN RECENT YEARS, INTEREST in studying the effects of sex hormones and gender on cardiovascular function has been growing. Basic and clinical investigations have shown important differences in the structure and function of the cardiovascular system between men and women (32). Several studies have shown that premenopausal women are protected from most cardiovascular events as compared with men (26). However, after the menopause, women are at an increased risk of cardiovascular complications as compared with premenopausal women (26). The pathophysiological mechanisms for such differences are not clear, but studies have shown that sex steroids make some contribution (30,36,42).Trauma is often seen in civilian and military situations. Hemorrhage and hemorrhagic shock are the major causes of early deaths in injured soldiers and in injuries due to accidents. Studies have shown that traumatic hemorrhagic shock accounts for Ϸ50% of deaths of battle personnel and for 66%-80% of trauma deaths (8, 13). Vascular responsiveness is a key factor in maintaining vascular tone and hemodynamic stability, helps to determine tissue perfusion, and affects other organ functions (23,24). ...

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“…(Simpson et al, 1988). Recently, we also reported that NMDA receptorassociated glycine receptors in the rat brain were far more susceptible to aging processes than NMDA receptors (Araki et al, 1996). These observations seem to suggest that glutamate transport sites may be more susceptible to aging processes than glutamate receptors.…”

Section: (Bc)mentioning

confidence: 96%

Age-related changes of sodium-dependentd-[3H]aspartate and [3H]FK506 binding in rat brain

Araki

Kato

Shuto

et al. 1997

J. Neural Transmission

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We investigated age-related changes in excitatory amino acid transport sites and FK506 binding protein (FKBP) in 3-week-, and 6-, 12-, 18- and 24-month-old Fischer 344 rat brains using receptor autoradiography. Sodium-dependent D-[3H]aspartate and [3H]FK506 were used to label excitatory amino acid transport sites and immunophilin (FKBP), respectively. In immature rats (3-week-old), sodium-dependent D-[3H]aspartate binding was lower in the frontal cortex, parietal cortex, striatum, nucleus accumbens, whole hippocampus, thalamus and cerebellum as compared to adult animals (6-month-old), whereas [3H]FK506 binding was significantly lower in only the hippocampus, thalamus and cerebellum. 3[H]FK506 binding exhibited no significant change in the brain regions examined during aging. However, sodium-dependent D-[3H]aspartate binding showed a conspicuous reduction in the substantia nigra in 18-month-old rats. Thereafter, a significant reduction in sodium-dependent D-[3H]aspartate binding was found in the thalamus, substantia nigra and cerebellum in 24-month-old rats. Other regions also showed about 10-25% reduction in sodium-dependent D-[3H]aspartate binding. The results indicate that excitatory amino acid transport sites are more susceptible to aging process than immunophilin. Further, our findings demonstrate the conspicuous differences in the developmental pattern between excitatory amino acid transport sites and immunophilin in immature rat brain.

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Different age-related changes in NMDA and glycine receptors in the rat brain

Cited by 5 publications

References 38 publications

Deficits in nitric oxide production after tetanic stimulation are related to the reduction of long‐term potentiation in Schaffer‐CA1 synapses in aged Fischer 344 rats

Deficits in nitric oxide production after tetanic stimulation are related to the reduction of long‐term potentiation in Schaffer‐CA1 synapses in aged Fischer 344 rats

Age and sex differences in vascular responsiveness in healthy and trauma patients: contribution of estrogen receptor-mediated Rho kinase and PKC pathways

Age-related changes of sodium-dependentd-[3H]aspartate and [3H]FK506 binding in rat brain

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