Different Activation of IL-10 in the Hippocampus and Prefrontal Cortex During Neurodegeneration Caused by Trimethyltin Chloride

Memory deficits and hippocampal cytokine expression in a rat model of ADHD

“…Similarly, in males, WKY rats showed elevated levels of IL-4 and significantly lower levels of IL-10 in the ventral hippocampus. Both IL-10 and IL-4 are anti-inflammatory cytokines known to regulate neuroinflammation and mitigate memory and plasticity impairments caused by excessive inflammation ( Lynch et al, 2004 ; Nolan et al, 2005 ; Richwine et al, 2009 ; Donzis and Tronson, 2014 ; Kamaltdinova et al, 2021 ). The elevated IL-4 levels in WKY males suggest potential protection from stress-induced neuroinflammation.…”

Molecular Mechanisms of Cognitive Impairment and Intellectual Disability—Virtual ESN Mini-Conference in Conjunction with the FENS Forum, July 11–15, 2020

“…Pershina (Institute of Theoretical and Experimental Biophysics, RAS, Pushchino, Russia) who presented a neurotoxic model of neurodegeneration based on rat treatment with trimethyltin chloride (TMT). This treatment was found to have different effects on expression of various subtypes of mGluRs (mGluR4, mGluR5, and mGluR7) in the hippocampus and prefrontal cortex of rats, which resulted in enhanced cell death in the hippocampus implying a different contribution of individual mGluR subtypes to neurodegeneration and/or neuroprotection (Kamaltdinova et al 2020;Pershina et al 2019).…”

Melatonin ameliorates trimethyltin chloride‐induced cardiotoxicity: The role of nuclear xenobiotic metabolism and Keap1‐Nrf2/ARE axis‐mediated pyroptosis

“…For example, workers were poisoned in the production of organotin stabilizers, PVC plastic processing and waste plastic processing. Occupational TMT poisoning is generally caused in multiple ways such as respiratory tract inhalation combined with skin and mucous membrane absorption 2 . A previous study revealed that TMT may result in nervous system damage with learning and memory dysfunction as the most prominent manifestation 3 .…”

“…Occupational TMT poisoning is generally caused in multiple ways such as respiratory tract inhalation combined with skin and mucous membrane absorption. 2 A previous study revealed that TMT may result in nervous system damage with learning and memory dysfunction as the most prominent manifestation. 3 A recent study showed that TMT in environmental exposure had certain peroxidation damage to the liver and kidney of rats.…”