Differences of Uric Acid Transporters Carrying Extracellular Vesicles in the Urine from Uric Acid and Calcium Stone Formers and Non-Stone Formers

Lin, Zhijian; Jayachandran, Muthuvel; Haskic, Zejfa; Kumar, Sanjay; Lieske, John C.

doi:10.3390/ijms231710010

Cited by 2 publications

(2 citation statements)

References 37 publications

(69 reference statements)

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“…In contrast, microvesicles are characterized by the presence of biomarkers like CD40, CD62, and integrin. The unique profiles of these biomarkers in exosomes and microvesicles facilitate their respective roles in intercellular communication, diagnostics, and therapeutic applications [ 16 , 17 ].…”

Section: Extracellular Vesicle (Evs)mentioning

confidence: 99%

Extracellular Vesicular miRNA in Pancreatic Cancer: From Lab to Therapy

Tiwari,

Shanmugam,

Karn

et al. 2024

Cancers

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Pancreatic cancer is a prevalent lethal gastrointestinal cancer that generally does not show any symptoms until it reaches advanced stages, resulting in a high mortality rate. People at high risk, such as those with a family history or chronic pancreatitis, do not have a universally accepted screening protocol. Chemotherapy and radiotherapy demonstrate limited effectiveness in the management of pancreatic cancer, emphasizing the urgent need for innovative therapeutic strategies. Recent studies indicated that the complex interaction among pancreatic cancer cells within the dynamic microenvironment, comprising the extracellular matrix, cancer-associated cells, and diverse immune cells, intricately regulates the biological characteristics of the disease. Additionally, mounting evidence suggests that EVs play a crucial role as mediators in intercellular communication by the transportation of different biomolecules, such as miRNA, proteins, DNA, mRNA, and lipids, between heterogeneous cell subpopulations. This communication mediated by EVs significantly impacts multiple aspects of pancreatic cancer pathogenesis, including proliferation, angiogenesis, metastasis, and resistance to therapy. In this review, we delve into the pivotal role of EV-associated miRNAs in the progression, metastasis, and development of drug resistance in pancreatic cancer as well as their therapeutic potential as biomarkers and drug-delivery mechanisms for the management of pancreatic cancer.

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Section: Extracellular Vesicle (Evs)mentioning

confidence: 99%

Extracellular Vesicular miRNA in Pancreatic Cancer: From Lab to Therapy

Tiwari,

Shanmugam,

Karn

et al. 2024

Cancers

Self Cite

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“…The culmination of this process occurs when MVBs merge with the PM, releasing ILVs as exosomes into the extracellular environment [ 5 , 23 , 24 ]. The orchestration of this intricate process leverages multiple proteins, including the endosomal sorting complexes required for transport (ESCRT), vacuolar ATPase, and Vps4, which are instrumental in segregating ubiquitinated proteins and directing them into ILVs [ 25 , 26 ]. Microvesicles are larger vesicles with dimensions typically spanning 100–1000 nm.…”

Section: Formation Of Evs and Mechanisms Of Exodna Loadingmentioning

confidence: 99%

Exosomal DNA: Role in Reflecting Tumor Genetic Heterogeneity, Diagnosis, and Disease Monitoring

Xiang,

Xie,

2023

Cancers

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Extracellular vesicles (EVs), with exosomes at the forefront, are key in transferring cellular information and assorted biological materials, including nucleic acids. While exosomal RNA has been thoroughly examined, exploration into exosomal DNA (exoDNA)—which is stable and promising for cancer diagnostics—lags behind. This hybrid genetic material, combining contributions from both nuclear and mitochondrial DNA (mtDNA), is rooted in the cytoplasm. The enigmatic process concerning its cytoplasmic encapsulation continues to captivate researchers. Covering the entire genetic landscape, exoDNA encases significant oncogenic alterations in genes like TP53, ALK, and IDH1, which is vital for clinical assessment. This review delves into exosomal origins, the ins and outs of DNA encapsulation, and exoDNA’s link to tumor biology, underscoring its superiority to circulating tumor DNA in the biomarker arena for both detection and therapy. Amidst scientific progress, there are complexities in the comprehension and practical application of the exoDNA surface. Reflecting on these nuances, we chart the prospective research terrain and potential pitfalls, forging a path for future inquiry. By illuminating both the known and unknown facets of exoDNA, the objective of this review is to provide guidance to the field of liquid biopsy (LB) while minimizing the occurrence of avoidable blind spots and detours.

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Differences of Uric Acid Transporters Carrying Extracellular Vesicles in the Urine from Uric Acid and Calcium Stone Formers and Non-Stone Formers

Cited by 2 publications

References 37 publications

Extracellular Vesicular miRNA in Pancreatic Cancer: From Lab to Therapy

Extracellular Vesicular miRNA in Pancreatic Cancer: From Lab to Therapy

Exosomal DNA: Role in Reflecting Tumor Genetic Heterogeneity, Diagnosis, and Disease Monitoring

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