Differences of the Anterior Segment Parameters in Children with Down Syndrome

Aslan, Lokman; Aslankurt, Murat; Aksoy, Alper; Gümüşalan, Yakup

doi:10.3109/13816810.2013.789535

Cited by 11 publications

(18 citation statements)

References 19 publications

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“…Although neural deficits at least partly constrain the visual acuity (VA) of children with DS, there are ocular disorders that further limit their visual functioning (Borstlap et al 2011). Compared to other children, many ocular findings in DS occur more frequently and in a more severe form (Creavin & Brown 2009;Little et al 2009b, Afifi et al 2013Aslan et al 2014;Watt et al 2015). In literature, the following prevalences have been reported: reduced visual acuity (poorer than 0.3 LogMar) in 80-100% and poor contrast sensitivity in almost all DS children (John et al 2004;Morton 2011;Little et al 2013;Watt et al 2015;Zahidi et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Effects of bifocals on visual acuity in children with Down syndrome: a randomized controlled trial

Weger

Boonstra

Goossens

2018

Acta Ophthalmologica

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Purpose Children with Down syndrome ( DS ) typically have reduced visual acuity ( VA ) and accommodation lag, but it is unclear whether prescribed glasses should correct both distance VA ( DVA ) and near VA ( NVA ) due to the lack of RCT s. We therefore conducted a multicentre RCT to compare the effects of bifocals designed to correct both DVA and NVA with distance‐correcting unifocal glasses in children with DS . Methods A total of 119 children with DS , aged 2–16, were randomly allocated for bifocal or unifocal glasses (with full correction of refraction error in cycloplegia) in 14 Dutch hospitals and followed during 1 year. VA data were analysed in relation to baseline VA with ancova . Results Treatment groups showed no differences at baseline. Shortly after receiving new corrections (~6 weeks), uncrowded NVA (bifocals 0.18 ± 0.33 LogMar; unifocals 0.09 ± 0.19 LogMar) and crowded NVA with bifocals (bifocals 0.13 ± 0.36 LogMar; unifocals 0.08 ± 0.33 LogMar) were significantly better than at baseline, but these short‐term improvements in NVA were not significantly different between the two treatments (p > 0.151). The 1‐year treatment differences were as follows: significantly larger improvement for bifocals compared to unifocals in both uncrowded NVA (bifocals 0.23 ± 0.29 LogMar, unifocals 0.12 ± 0.30 LogMar, p = 0.045) and crowded NVA (bifocals 0.31 ± 0.28 LogMar; unifocals 0.16 ± 0.30 LogMar, p = 0.017). Improvements in DVA were comparable (bifocals 0.07 ± 0.21 LogMar, unifocals 0.08 ± 0.22 LogMar, p = 0.565). Children with poor baseline VA improved more. Accommodation lag stayed unchanged. Conclusion After one year, bifocals with full correction of ametropia led to significantly larger improvement of both uncrowded NVA and crowded NVA in children with DS with accommodation lag compared to unifocals.

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Section: Introductionmentioning

confidence: 99%

Effects of bifocals on visual acuity in children with Down syndrome: a randomized controlled trial

Weger

Boonstra

Goossens

2018

Acta Ophthalmologica

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“…[ 21 ] To our knowledge, there has been no study on this topic in patients with Down syndrome except for the study by Aslan et al . [ 17 ] in Turkey and Haugen et al . [ 18 ] in Norway.…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, there has been no population-based study to evaluate AC parameters in 10- to 30-year-old patients with Down syndrome. In a study by Aslan et al .,[ 17 ] ACV, ACD and PD were reported in 38 patients with Down syndrome aged 5-13 years. Also, Haugen et al .…”

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confidence: 99%

Anterior chamber dimensions, angles and pupil diameter in patients with Down syndrome: A comparative population-based study

Asgari

Hashemi

Fotouhi

et al. 2020

Indian J Ophthalmol

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Purpose: To study the anterior chamber (AC) dimensions, angles and pupil diameter (PD) in patients with Down syndrome compared to normal controls. Methods: Prospective study is comparing the AC parameters in patients with Down syndrome aged 10-30 years and age-matched controls. Extracted indices included average anterior chamber depth on the 2-mm ring (ACD-2 mm), 4-mm ring (ACD-4 mm), at the corneal apex from the endothelium (endo-ACD), at the corneal apex from the epithelium (epi-ACD), anterior chamber volume (ACV), mean anterior chamber angle (ACA), and PD measured by Pentacam. Results: Data from 202 patients with Down syndrome (age 17.2 ± 4.8 years) were compared with 190 normal controls (age 17.2 ± 4.5 years). In Down and normal groups, mean ± SD were 2.51 ± 0.31 and 2.83 ± 0.34 mm for ACD-2 mm, 1.65 ± 0.30 and 1.93 ± 0.31 mm for ACD-4 mm, and 3.03 ± 0.29 and 3.24 ± 0.26 mm for endo-ACD, 3.54 ± 0.29 and 3.80 ± 0.26 mm for epi-ACD, mean 169.31 ± 30.38 and 200.17 ± 33.20 mm 3 for ACV, 40.69 ± 4.50 and 39.97 ± 4.12° for ACA, and 2.79 ± 0.62 and 3.59 ± 0.80 mm for PD, respectively (all P < 0.001). None of the studied indices significantly correlated with age, except for ACA ( P = 0.011). All parameters, except for PD, were significantly higher in males compared to females (all P < 0.001). Temporal ACA was significantly wider in male subjects (44.61 ± 6.52 vs. 42.24 ± 6.52°; P < 0.001). Conclusion: The AC in patients with Down syndrome is smaller than normal individuals. AC in females with Down syndrome is smaller than males, and the narrower ACA is attributable to the difference in the temporal angle and not the ACA in other meridians.

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“…Reports show a 0.5–15% incidence of keratoconus in patients with Down syndrome, which is much higher than in the general population (1:2000) [ 2 – 6 ]. Keratoconus can be detected at earlier stages with corneal topography, a reliable instrument for screening and diagnosis in patients with Down syndrome [ 7 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

Performing corneal crosslinking under local anaesthesia in patients with Down syndrome

2017

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PurposeTo report on the ability to perform corneal crosslinking (CXL) under local anaesthesia for the treatment of keratoconus in patients with Down syndrome.MethodsNine eyes of seven patients with both keratoconus and Down syndrome were scheduled for an epithelium-off CXL procedure under local anaesthesia. Exclusion criteria were a corneal thickness under 400 µm and the presence of corneal scars. A standardized clinical decision tool was used to estimate patient cooperation and the likelihood for a successful procedure under local rather than general anaesthesia.ResultsIn seven eyes, the CXL was completed successfully. The treatment was aborted in two eyes due to insufficient corneal thickness (<400 µm) prior to ultraviolet-A irradiation, even after employing hypoosmolar riboflavin. No adverse events occurred post-operatively, except for one case of delayed epithelial healing (23 days).ConclusionsWith a proper patient selection, CXL under local anaesthesia can be achieved in patients with Down syndrome.

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Differences of the Anterior Segment Parameters in Children with Down Syndrome

Cited by 11 publications

References 19 publications

Effects of bifocals on visual acuity in children with Down syndrome: a randomized controlled trial

Effects of bifocals on visual acuity in children with Down syndrome: a randomized controlled trial

Anterior chamber dimensions, angles and pupil diameter in patients with Down syndrome: A comparative population-based study

Performing corneal crosslinking under local anaesthesia in patients with Down syndrome

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