Differences of Intracranial Electrical Stimulation Thresholds in the Human Brain

Stephani, Caspar; Koubeissi, Mohamad Z.

doi:10.1016/j.brs.2015.02.011

Cited by 7 publications

(5 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 1975, Adams showed that pain relief mediated with deep brain stimulation at 10 Hz could be reversed with naloxone. Today, deep brain stimulation as low as 1 Hz is used to prevent seizures in epilepsy (59–64). In all, these modalities demonstrate the effects of very low‐frequency stimulation in neuromodulation interventions.…”

Section: Very Low Frequency and Neuromodulationmentioning

confidence: 99%

Mechanisms for the Clinical Utility of Low-Frequency Stimulation in Neuromodulation of the Dorsal Root Ganglion

Chapman

Yousef

Foster

et al. 2021

Neuromodulation: Technology at the Neural Interface

View full text Add to dashboard Cite

Section: Very Low Frequency and Neuromodulationmentioning

confidence: 99%

Mechanisms for the Clinical Utility of Low-Frequency Stimulation in Neuromodulation of the Dorsal Root Ganglion

Chapman

Yousef

Foster

et al. 2021

Neuromodulation: Technology at the Neural Interface

View full text Add to dashboard Cite

“…We use preoperative DTI for identifying the tracts at risk each time, and then depth electrodes may be inserted along their pathway for stimulating and mapping in detail these tracts. However, it is beyond any doubt that intraoperative stimulation is superior to extra-operative stimulation and mapping through multiple depth electrodes or stereo-EEG [ 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ].…”

Section: Discussionmentioning

confidence: 99%

“…We also employed preoperative DTI in our patients (as we routinely do ), mostly for guiding us in the gross location of the tracts at jeopardy each time. This may facilitate the whole stimulation process and diminish the necessary time for stimulation and mapping; at the same time the accuracy of the DTI can be assessed intraoperatively by the employed stimulation [ 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. An adequate-size craniotomy for implanting all the electrodes under direct vision to avoid any surface venous injuries is essential.…”

Section: Discussionmentioning

confidence: 99%

The Role of Extra-Operative Cortical Stimulation and Mapping in the Surgical Management of Intracranial Gliomas

et al. 2022

View full text Add to dashboard Cite

Background: Aggressive resection without compromising the patient’s neurological status remains a significant challenge in treating intracranial gliomas. Our current study aims to evaluate the efficacy and safety of extra-operative stimulation and mapping via implanted subdural electrodes with or without depth (EOCSM), offering an alternative approach when awake mapping is contraindicated. Methods: Fifty-one patients undergoing EOCSM for glioma resection in our institution formed the sample study of our current retrospective study. We assessed the effectiveness and safety of our approach by measuring the extent of resection and recording the periprocedural complications, respectively. Results: The mean age of our participants was 58 years (±9.4 years). The lesion was usually located on the left side (80.4%) and affected the frontal lobe (51.0%). EOCSM was successful in 94.1% of patients. The stimulation and electrode implantation procedures lasted for a median of 2.0 h and 75 h, respectively. Stimulation-induced seizures and CSF leakage occurred in 13.7% and 5.9% of our cases. The mean extent of resection was 91.6%, whereas transient dysphasia occurred in 21.6% and transient hemiparesis in 5.9% of our patients, respectively. Conclusions: Extraoperative stimulation and mapping constitute a valid alternative mapping option in glioma patients who cannot undergo an awake craniotomy.

show abstract

“…Third, whereas cortical stimulation activates both excitatory axons and inhibitory dendrites, white matter stimulation affects only axons. This results in a higher net current, as only the excitatory components of the circuit are triggered [31].…”

Section: Why White Matter Stimulation?mentioning

confidence: 99%

White matter stimulation for the treatment of epilepsy

Girgis

Miller

2016

Seizure

View full text Add to dashboard Cite

Electrical stimulation in the treatment of epilepsy has been tried in numerous forms and with a variety of targets. Some of these, such as anterior thalamic stimulation, responsive cortical stimulation, and vagal nerve stimulation, have shown promise. A relatively novel concept, that of white matter stimulation, offers a different mechanism in that a small population of stimulated axons can transmit current to a large population of epileptogenic neurons. In theory, this allows for the modulation of seizure circuits and neural networks using lower stimulation volumes. Although clinical data is currently sparse, we review the relevant studies pertaining to white matter stimulation in epilepsy thus far, and offer explanations as to its effects, potential advantages, and utility.

show abstract

Differences of Intracranial Electrical Stimulation Thresholds in the Human Brain

Cited by 7 publications

References 33 publications

Mechanisms for the Clinical Utility of Low-Frequency Stimulation in Neuromodulation of the Dorsal Root Ganglion

Mechanisms for the Clinical Utility of Low-Frequency Stimulation in Neuromodulation of the Dorsal Root Ganglion

The Role of Extra-Operative Cortical Stimulation and Mapping in the Surgical Management of Intracranial Gliomas

White matter stimulation for the treatment of epilepsy

Contact Info

Product

Resources

About