Differences of IgG and IgM Antibodies to Phospholipids and APTT among Non‐Pregnant and Pregnant Women

Shimano, Shunichi; Kurosu, Takaji; Hayama, Kenji; Ishida, Y.; Komae, Yoshio

doi:10.1111/j.1447-0756.1998.tb00093.x

Cited by 3 publications

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the hypercoagulable state of pregnancy is so well described [5, 10, 11, 15–17, 21], we were surprised to find few papers on reference ranges for haematology tests in pregnancy [7, 22, 23], although data do exist for other standard laboratory tests in pregnancy [21, 24–26]. It is reassuring that the current study has demonstrated broadly similar reference ranges for PT and APTT in pregnancy compared with the laboratory ranges, but our finding of higher fibrinogen levels in pregnancy should be considered when interpreting standard coagulation tests in the peripartum period.…”

Section: Discussionsupporting

confidence: 52%

Reference ranges for thromboelastography (TEG^®) and traditional coagulation tests in term parturients undergoing caesarean section under spinal anaesthesia*

Macafee¹,

Campbell²,

Ashpole

et al. 2012

Anaesthesia

View full text Add to dashboard Cite

SummaryThere has been little published work defining 'normal' thromboelastography (TEG Ò ) values in healthy parturients, and few large studies defining reference ranges for traditional coagulation tests in this patient group. Our aim was to establish peri-operative reference ranges for TEG and for standard laboratory coagulation tests in our pregnant population. Fifty healthy term parturients presenting for elective caesarean section under spinal anaesthesia had blood samples taken pre-operatively, on arrival in the recovery room and, in a subset of 33 women, 4 h after routine thromboprophylaxis with enoxaparin 40 mg. All three samples had TEG analysis, the first and second having standard laboratory coagulation tests in addition. Reference ranges for our pregnant population were established, demonstrating a hypercoagulable state in term parturients and a significant effect of enoxaparin. The standard coagulation reference ranges were within 98% of the local non-pregnant ranges. These reference ranges provide a useful comparator for peri-operative TEG and routine coagulation analysis in term parturients. Accepted: 26 January 2012The recent decline in direct maternal deaths in the UK has been attributed largely to reductions in deaths due to thromboembolism, and, to a lesser extent, haemorrhage [1]. With increased awareness and more widespread use of thromboprophylaxis, and the ever-present risk of maternal haemorrhage, greater importance is being placed on the assessment of coagulation status and blood product replacement during the peripartum period.Thromboelastography (TEG Ò ) is a relatively new near-patient monitor of coagulation in UK labour wards, although its use in cardiac and liver surgery is long-standing [2,3]. The TEG evaluates the mechanical strength of clot during its formation, via the torsion in a pin suspended in an oscillating heated cup that contains the blood sample [4], leading to a graphical output (Fig. 1). Compared with traditional laboratory coagulation tests, the TEG takes into account the dynamic interaction of plasma (clotting factors) and cellular (platelets) elements that occurs during in vivo clotting, thus indicating overall 'clot quality.' Test protocols can

show abstract

Section: Discussionsupporting

confidence: 52%

Reference ranges for thromboelastography (TEG^®) and traditional coagulation tests in term parturients undergoing caesarean section under spinal anaesthesia*

Macafee¹,

Campbell²,

Ashpole

et al. 2012

Anaesthesia

View full text Add to dashboard Cite

show abstract

Venous Thromboembolism During Pregnancy* *Venous thromboembolism (VTE) during pregnancy has many parallels with disorders are considered to be at high risk for thrombosis VTE in nonpregnant individuals. The differences are emphasized. Various aspects of thrombosis in pregnancy have been well summarized in several secondary sources, including the version of this chapter in the third edition of this volume and in original papers in the clinical literature.9–13 I have consulted these secondary sources and jou

McPhedran¹

2004

Medical Complications During Pregnancy

View full text Add to dashboard Cite

Anticardiolipin antibodies in ectopic pregnancies

Jacob-Meisel

Römer

Straube

et al. 2001

European Journal of Obstetrics & Gynecology and Reproductiv

View full text Add to dashboard Cite

Differences of IgG and IgM Antibodies to Phospholipids and APTT among Non‐Pregnant and Pregnant Women

Abstract: Standard criteria for the positivity of the IgG antibody to CL and PS and the prolongation of APTT in pregnancy should employ the values of normal pregnant women rather than those of non-pregnant women.

Cited by 3 publications

References 11 publications

Reference ranges for thromboelastography (TEG^®) and traditional coagulation tests in term parturients undergoing caesarean section under spinal anaesthesia*

Reference ranges for thromboelastography (TEG^®) and traditional coagulation tests in term parturients undergoing caesarean section under spinal anaesthesia*

Anticardiolipin antibodies in ectopic pregnancies

Contact Info

Product

Resources

About

Differences of IgG and IgM Antibodies to Phospholipids and APTT among Non‐Pregnant and Pregnant Women

Abstract: Standard criteria for the positivity of the IgG antibody to CL and PS and the prolongation of APTT in pregnancy should employ the values of normal pregnant women rather than those of non-pregnant women.

Cited by 3 publications

References 11 publications

Reference ranges for thromboelastography (TEG®) and traditional coagulation tests in term parturients undergoing caesarean section under spinal anaesthesia*

Reference ranges for thromboelastography (TEG®) and traditional coagulation tests in term parturients undergoing caesarean section under spinal anaesthesia*

Anticardiolipin antibodies in ectopic pregnancies

Contact Info

Product

Resources

About

Reference ranges for thromboelastography (TEG^®) and traditional coagulation tests in term parturients undergoing caesarean section under spinal anaesthesia*

Reference ranges for thromboelastography (TEG^®) and traditional coagulation tests in term parturients undergoing caesarean section under spinal anaesthesia*