Differences of Corneal Biomechanics Among Thin Normal Cornea, Forme-Fruste Keratoconus, and Cornea After SMILE

Zhang, Di; Tian, Lei; Zhang, Haixia; Zheng, Yang; Fu, Caiyun; Zhai, Changbin; Jin, Ying; Li, Lin

doi:10.3389/fbioe.2022.861924

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…The biomechanical properties of the cornea may also change as it thins. Studies on the biomechanical properties of the cornea following laser refractive surgery have mainly used an ocular response analyzer [2,[6][7][8][9][10][11][12][13][14][15], with a limited number of studies using a Dynamic Scheimp ug Analyzer (Corvis ST; OCULUS, Wetzlar, Germany) [16][17][18][19][20][21][22][23][24]. Furthermore, to the best of our knowledge, no study has assessed the relationship between PCE and biomechanical parameters postoperatively.…”

Section: Introductionmentioning

confidence: 99%

Changes in posterior corneal elevation and associated factors following small incision lenticule extraction in patients with high myopia and thin cornea: a prospective non-randomized clinical study

Zhao,

Hu,

Mao

et al. 2023

Preprint

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Background Small incision lenticule extraction (SMILE) is a popular procedure for correcting myopia and myopic astigmatism; however, the cornea thins to varying degrees following SMILE surgery, and its postoperative stability may be affected. We investigated the safety and efficacy of SMILE in patients with high myopia and analyzed the factors influencing corneal posterior elevation variation (PCE). Methods This was a prospective non-randomized clinical study. Patients with a corneal thickness < 530 µm at the thinnest point of the right eye with a spherical equivalent (SE) ≤-3.00D (group A: ≤-3.00D, >-6.00D; group B: ≤-6.00D, >-10.00D) who underwent SMILE surgery between January 1, 2020, and May 31, 2021. We compared the difference in postoperative vertex PCE between the two groups and assessed the correlation between PCE variation (△PCE) and corneal biomechanical parameters. Results The preoperative SE was − 4.74 ± 0.63D and − 7.38 ± 1.22D in groups A (41 eyes) and B (37 eyes), respectively. PCE was 0.61 ± 2.07 and 0.16 ± 2.19 µm, and △PCE was 0.93 ± 1.13 and − 1.43 ± 1.07 µm in groups A and B, respectively, showing significant differences (P < 0.05). △A2L and △A2V (r=-0.41, -0.36; P = 0.02, 0.04) were correlated with △PCE. Stepwise regression analysis showed that △A2L was the predictor variable of △PCE (AIC = 0.8, P = 0.02). Conclusions SMILE surgery is safe and effective for correcting high myopia with a thin cornea. A2L may affect the variation of vertex PCE following SMILE surgery. The higher reduction in A2L leads to less PCE backward displacement.

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Section: Introductionmentioning

confidence: 99%

Changes in posterior corneal elevation and associated factors following small incision lenticule extraction in patients with high myopia and thin cornea: a prospective non-randomized clinical study

Zhao,

Hu,

Mao

et al. 2023

Preprint

View full text Add to dashboard Cite

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Comparisons of corneal biomechanical and higher-order aberrations between thin normal cornea and Forme Fruste keratoconus

Liu,

Liu

et al. 2024

Preprint

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Background To compare the corneal biomechanical parameters and higher-order aberrations (HOAs) of thin normal cornea (TNC) and Forme Fruste keratoconus (FFKC). Methods The data collected between June 2018 and May 2023 at the Eye Hospital Affiliated with Shandong First Medical University were divided into two groups: 26 normal eyes of 26 patients (18–38 years) with the thinnest corneal thickness (TCT) ≤ 500 µm and 26 eyes of 26 patients (14–35 years) with FFKC. Central corneal thickness (CCT) and biomechanical-corrected intraocular pressure (bIOP) were matched by propensity score matching. Scheimpfug imaging (Pentacam) and corneal visualization Scheimpfug technology (Corvis ST) were used to compare the variations in corneal biomechanical parameters and HOAs between the two groups. The receiver operating characteristic (ROC) curve was used to judge the accuracy of significantly different parameters in predicting FFKC. The FFKC diagnostic model was established using the best discriminant function. Results The time of the first applanation (A1T), the velocity of corneal movement during the second applanation (A2V), the time at which the cornea reached the highest concavity (HCT) and the total corneal root mean square (RMS) of the HOA were significantly different between the two groups (P < 0.05). HCT showed good potential for distinguishing between FFKC and TNC. The best discriminant function showed a prediction accuracy of 78.4%. Conclusion This study suggested that the relationship between certain biomechanical properties and HOAs could be valuable for the diagnosis of FFKC.

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Effect of corneal diameter on preoperative screening results for corneal refractive surgery

Zhang

2024

Am J Transl Res

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Differences of Corneal Biomechanics Among Thin Normal Cornea, Forme-Fruste Keratoconus, and Cornea After SMILE

Cited by 3 publications

References 36 publications

Changes in posterior corneal elevation and associated factors following small incision lenticule extraction in patients with high myopia and thin cornea: a prospective non-randomized clinical study

Changes in posterior corneal elevation and associated factors following small incision lenticule extraction in patients with high myopia and thin cornea: a prospective non-randomized clinical study

Comparisons of corneal biomechanical and higher-order aberrations between thin normal cornea and Forme Fruste keratoconus

Effect of corneal diameter on preoperative screening results for corneal refractive surgery

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