Differences of apathy perfusion correlates between Alzheimer’s disease and frontotemporal dementia. A 99mTc-HMPAO SPECT study with automated Brodmann areas analysis

Valotassiou, Varvara; Sifakis, Nikolaos; Tzavara, Chara; Lykou, Evi; Tsinia, Niki; Kamtsadeli, Vasiliki; Sali, Dimitra; Angelidis, George; Psimadas, Dimitrios; Tsougos, Ioannis; Papageorgiou, Sokratis G.; Georgoulias, Panagiotis; Papatriantafyllou, John

doi:10.1080/13651501.2020.1846752

Cited by 4 publications

(6 citation statements)

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“…Apathy and disinhibition were the main behavior symptoms in bvFTD of which the neuroanatomical correlates were widely investigated and demonstrated the significant contributions of the prefrontal cortex ( Farb et al, 2013 ; Godefroy et al, 2022 ; Sheelakumari et al, 2020 ; Tanguy et al, 2022 ; Zhou et al, 2021 ). More specifically, the orbital frontal gyrus was one of the significant brain regions in the frontal-temporal-limbic circuit discovered in previous studies that contribute to apathy using other image modalities ( Godefroy et al, 2022 ; Valotassiou et al, 2022 ). And it is well-acknowledged that orbital frontal gyrus is linked to impulsive and disinhibition behavior ( Migliaccio et al, 2020 ; Pattij and Vanderschuren, 2020 ; Tanguy et al, 2022 ), imbalanced activity in the orbitofrontal cortex and nucleus accumbens was known to disrupt behavior inhibition ( Meyer and Bucci, 2016 ).…”

Section: Discussionmentioning

confidence: 94%

Clinical relevance of disrupted topological organization of anatomical connectivity in behavioral variant frontotemporal dementia

Chu

Jiang

liu

et al. 2023

Neurobiology of Aging

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Section: Discussionmentioning

confidence: 94%

Clinical relevance of disrupted topological organization of anatomical connectivity in behavioral variant frontotemporal dementia

Chu

Jiang

liu

et al. 2023

Neurobiology of Aging

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“…Apathy showed the highest reported frequency in FTD including bvFTD in ten studies [ 12 , 21 , 23 , 76 – 82 ], while only two studies addressed PPA [ 76 , 78 ]. In studies comparing FTD with AD, FTD patients had a higher prevalence of apathy [ 12 , 21 ] and higher apathy scores [ 83 , 84 ] than AD patients. Only one study highlighted a higher prevalence of apathy in patients with bvFTD in its early stage [ 82 ].…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies used NPI [ 21 , 76 , 78 , 80 , 82 , 84 – 86 ], and five studies used AES [ 14 , 23 , 78 , 81 ]. One study used LARS [ 12 ], three used CBI-R [ 21 , 76 , 77 ], two used the Motivation and Energy Inventory (MEI) [ 76 , 78 ], three used the Snaith-Hamilton Pleasure Scale (SHAPS) [ 76 , 78 , 79 ], one used DAD [ 21 ], two used the Social and Emotional Assessment (Mini-SEA) [ 82 , 87 ], one used AS [ 87 ], DAS was used in four studies [ 23 , 79 , 83 , 88 ], one used the goal-directed behaviors (GDB) [ 81 ], and one used FBI [ 89 ].…”

Section: Resultsmentioning

confidence: 99%

Prevalence, treatment, and neural correlates of apathy in different forms of dementia: a narrative review

Parrotta,

Cacciatore,

D’Andrea

et al. 2023

Neurol Sci

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Objectives The aim of this review is to provide an overview on prevalence and clinical tools for the diagnosis of apathy, as well as on neurophysiological and neuroimaging findings obtained from studies in patients with apathy in different forms of dementia, including Alzheimer’s disease (AD), vascular (VaD) and mixed dementia, frontotemporal dementia (FTD), and Parkinson’s disease dementia (PDD). Methods Randomized controlled trials, non-randomized controlled trials, controlled before–after studies, and interrupted time series from four databases (WebOfScience, Scopus, Pubmed, and PsycINFO) addressing apathy in adults or older people aged over 65 years of age affected by dementia were included. Results The prevalence of apathy was 26–82% for AD, 28.6–91.7 for VaD, 29–97.5% in PDD, and 54.8–88.0 in FTD. The assessment of apathy was not consistent in the reviewed studies. Methylphenidate was the most successful pharmacological treatment for apathy. Neurobiological studies highlighted the relationship between both structural and functional brain areas and the presence or severity of apathy. Conclusion Apathy is a very common disorder in all types of dementia, although it is often underdiagnosed and undertreated. Further studies are needed to investigate its diagnosis and management. A consensus on the different evaluation scales should be achieved.

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“…In our study, hypoperfusion in groups II and older groups was observed. Within consistent, several studies reported that most of or specifically the temporoparietal regions were hypoperfused in small animal models and human Alzheimer’s disease [ 80 , 83 ], and frontotemporal dementia [ 84 ]. Aging was reported to be a risk factor for developing cognitive impairment, neurodegeneration, and the subsequent appearance of dementia [ 85 , 86 ].…”

Section: Discussionmentioning

confidence: 99%

Geraniol attenuates oxidative stress and neuroinflammation-mediated cognitive impairment in D galactose-induced mouse aging model

Rajendran,

Al-Saeedi,

Ammar

et al. 2024

Aging

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D-galactose (D-gal) administration was proven to induce cognitive impairment and aging in rodents’ models. Geraniol (GNL) belongs to the acyclic isoprenoid monoterpenes. GNL reduces inflammation by changing important signaling pathways and cytokines, and thus it is plausible to be used as a medicine for treating disorders linked to inflammation. Herein, we examined the therapeutic effects of GNL on D-gal-induced oxidative stress and neuroinflammation-mediated memory loss in mice. The study was conducted using six groups of mice (6 mice per group). The first group received normal saline, then D-gal (150 mg/wt) dissolved in normal saline solution (0.9%, w/v) was given orally for 9 weeks to the second group. In the III group, from the second week until the 10th week, mice were treated orally (without anesthesia) with D-gal (150 mg/kg body wt) and GNL weekly twice (40 mg/kg body wt) four hours later. Mice in Group IV were treated with GNL from the second week up until the end of the experiment. For comparison of young versus elderly mice, 4 month old (Group V) and 16-month-old (Group VI) control mice were used. We evaluated the changes in antioxidant levels, PI3K/Akt levels, and Nrf2 levels. We also examined how D-gal and GNL treated pathological aging changes. Administration of GNL induced a significant increase in spatial learning and memory with spontaneously altered behavior. Enhancing anti-oxidant and anti-inflammatory effects and activating PI3K/Akt were the mechanisms that mediated this effect. Further, GNL treatment upregulated Nrf2 and HO-1 to reduce oxidative stress and apoptosis. This was confirmed using 99m Tc-HMPAO brain flow gamma bioassays. Thus, our data suggested GNL as a promising agent for treating neuroinflammation-induced cognitive impairment.

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Differences of apathy perfusion correlates between Alzheimer’s disease and frontotemporal dementia. A 99mTc-HMPAO SPECT study with automated Brodmann areas analysis

Cited by 4 publications

References 84 publications

Clinical relevance of disrupted topological organization of anatomical connectivity in behavioral variant frontotemporal dementia

Clinical relevance of disrupted topological organization of anatomical connectivity in behavioral variant frontotemporal dementia

Prevalence, treatment, and neural correlates of apathy in different forms of dementia: a narrative review

Geraniol attenuates oxidative stress and neuroinflammation-mediated cognitive impairment in D galactose-induced mouse aging model

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