Differences in white matter detected byex vivo9.4T MRI are associated with axonal changes in the R6/1 model of Huntington’s Disease
C. Casella,
B. Kelly,
A. Murillo Bartolome
et al.
Abstract:White matter (WM) volume loss has been reported in people with Huntington’s disease (HD), but the cellular basis of this deficit remains to be elucidated. To address this, we assessed ex vivo WM microstructure in the transgenic R6/1 mouse model of HD with magnetic resonance imaging (MRI) and studied the neurobiological basis of the MRI brain signals with histological and electron microscopy analyses in a separate cohort of age- and sex-matched mice. Differences in the macromolecular proton fraction (MPF) from … Show more
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