Differences in vascular reactivity between pregnant women with chronic hypertension and preeclampsia

Mori, Toshitaka; Watanabe, Kazushi; Iwasaki, Ai; Kimura, Chiharu; Matsushita, Hiroshi; Shinohara, Koichi; Wakatsuki, Akihiko

doi:10.1038/hr.2013.131

Cited by 39 publications

(43 citation statements)

References 31 publications

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“…Our results were consistent with previous studies. Mori et al 27 reported that BP in women with preeclampsia significantly decreased a month after delivery, whereas BP remained higher than in normotensive mothers. Furthermore, nighttime systolic BP in the ambulatory setting was significantly (P = 0.030) elevated in Swedish women with preeclampsia compared with those without preeclampsia even 11 years after delivery, although this was not the case for the other BP data (P ⩾ 0.073).…”

Section: Discussionmentioning

confidence: 97%

Relationship between maternal gestational hypertension and home blood pressure in 7-year-old children and their mothers: Tohoku Study of Child Development

et al. 2015

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Women who had hypertensive disorders in pregnancy have an increased risk of cardiovascular diseases in later life. No studies, however, have investigated whether maternal hypertensive disorders in pregnancy affect self-measured blood pressure at home (HBP) in mothers and their children. We evaluated the association between maternal hypertension during pregnancy and HBP based on the prospective Tohoku Study of Child Development birth cohort study, which was performed in two areas in Japan. We included children in a singleton birth at term (36-42 weeks of gestation) with a birth weight of >2400 g. We collected prenatal care data from the medical charts. Because only two mothers experienced preeclampsia, we defined gestational hypertension (GH) as a hypertensive disorder in pregnancy. Seven years after birth, mothers and their children measured their HBP in the morning for 2 weeks. Of 813 eligible mothers, 28 (3.4%) experienced GH, and those were of a similar age compared with 785 non-GH mothers (37.3 vs. 38.0 years; P=0.41). Women with GH had higher body mass index (BMI) (23.8 vs. 21.4 kg m(-)(2); P=0.01) and elevated HBP (120.3/76.8 vs. 110.4/68.6 mm Hg; P<0.0002) 7 years after delivery. However, HBP was similar in children with and without GH mothers (93.5/55.9 vs. 94.1/56.1 mm Hg, P>0.38). These results were confirmatory in case-control (1:2) analyses with matching by maternal age, maternal BMI before pregnancy, survey area and parity. In conclusion, maternal GH did not affect HBP in offspring but strongly affected maternal HBP even 7 years after birth.

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Section: Discussionmentioning

confidence: 97%

Relationship between maternal gestational hypertension and home blood pressure in 7-year-old children and their mothers: Tohoku Study of Child Development

et al. 2015

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“…On the other hand, when Mori et al [93 ]measured FMD in women who had had PE and those with a normal pregnancy, they found that the vasodilator response (significantly reduced in the preeclamptic group during pregnancy) normalized 1 month after delivery. …”

Section: Evaluation Of Endothelial Dysfunction By Fmdmentioning

confidence: 99%

Preeclampsia and Maternal Cardiovascular Disease: Consequence or Predisposition?

Osol

Bernstein²

2014

J Vasc Res

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Formerly preeclamptic women stand a higher chance of developing cardiovascular disease (CVD) later in life and may experience a shortened life span. This review updates the pathophysiology and definition of this complex disease and highlights the protective role of pregnancy by considering the relationship between pregnancy interval and likelihood of disease recurrence. The evidence for persistent maternal cardiovascular impairment following preeclampsia (PE) is considered, e.g. postpartum changes in CVD occurrence, blood pressure elevation and changes in the renin-angiotensin-aldosterone system). Since maternal endothelial dysfunction is a hallmark of PE, we summarize the evidence for reduced flow-mediated dilation in women with previous PE, and consider the utility and shortcomings of this clinical measure. In addition to viewing postpartum changes as a consequence of this disease, we consider the alternative view that PE might be the manifestation of a maternal phenotype that already has some predisposition to or is in the earlier stages of CVD; in this case, some of the postpartum residual deficits (or their antecedents) may have already been present prior to pregnancy. Finally, we consider the use of novel biomarkers for predicting or detecting PE prior to the appearance of clinical symptoms.

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“…8<11 We have also previously reported that plasma triglycerides (TG) and lowdensity lipoprotein cholesterol (LDL-C) levels were higher, and insulin resistance was greater, in women with preeclampsia. 3,5 Thus, women with preeclampsia may be at increased risk for CVD.…”

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confidence: 99%

Pregnancy-induced hypertension is associated with an increase in the prevalence of cardiovascular disease risk factors in Japanese women

et al. 2015

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Differences in vascular reactivity between pregnant women with chronic hypertension and preeclampsia

Cited by 39 publications

References 31 publications

Relationship between maternal gestational hypertension and home blood pressure in 7-year-old children and their mothers: Tohoku Study of Child Development

Relationship between maternal gestational hypertension and home blood pressure in 7-year-old children and their mothers: Tohoku Study of Child Development

Preeclampsia and Maternal Cardiovascular Disease: Consequence or Predisposition?

Pregnancy-induced hypertension is associated with an increase in the prevalence of cardiovascular disease risk factors in Japanese women

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