Differences in Trace Metal Concentrations (Co, Cu, Fe, Mn, Zn, Cd, and Ni) in Whole Blood, Plasma, and Urine of Obese and Nonobese Children

Błażewicz, Anna; Klatka, Maria; Astel, Aleksander; Partyka, Małgorzata; Kocjan, Ryszard

doi:10.1007/s12011-013-9783-8

Cited by 77 publications

(56 citation statements)

References 46 publications

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“…A lack of Zn in the body leads to a number of disorders associated with obesity [61]. In addition, changes in zinc levels in the body are a marker of various inflammatory processes, including obesity [62,63]. In our experiment, we observed a recovery of Zn levels in the DIO + DDW group to those of the Control + MilliQ group.…”

Section: Discussionsupporting

confidence: 53%

Deuterium-Depleted Water as Adjuvant Therapeutic Agent for Treatment of Diet-Induced Obesity in Rats

et al. 2019

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In this study, we present the potential application of deuterium-depleted water (DDW) for the prevention and adjuvant treatment of obesity in rats. We tested the hypothesis that DDW can alleviate diet-induced obesity (DIO) and its associated metabolic impairments. Rats fed a high-fat diet had an increased body weight index (BWI), glucose concentration, and level of certain proinflammatory cytokines; decreased levels of insulin in the serum; decreased tryptophan and serotonin in the brain, and a decreased concentration of some heavy metals in the liver. Drinking DDW at a concentration of 10 ppm deuterium/protium (D/H) ad libitum for 3 weeks restored the BWI, glucose (serum), tryptophan (brain), and serotonin (brain) levels and concentration of Zn in the liver in the DIO animals to those of the controls. The levels of proinflammatory cytokines (IL-1β, IL-6, IFNγ) and anti-inflammatory TNFα were decreased in DIO rats, while anti-inflammatory cytokine (IL-4, IL-10) levels remained at the control levels, which is indicative of a pathophysiological syndrome. In contrast, in groups of rats treated with DDW, a significant increase in anti-inflammatory (IL-4, IL-10) and proinflammatory cytokines (IFNγ) was observed. This finding indicates a reduction in systemic inflammation in obese animals treated with DDW. Similarly, the high-fat diet caused an increased level of oxidative stress products, which was accompanied by decreased activity of both superoxide dismutase and catalase, whereas the administration of DDW decreased the level of oxidative stress and enhanced antioxidant enzyme activities.Molecules 2020, 25, 23 2 of 15 the development of new, safer and more effective pharmaceutical approaches for obesity treatment is essential.Natural water is a mixture of molecules containing stable isotopes 16 O, 17 O, 18 O, 1 H, and 2 H. The ratio of deuterium atoms to protium (D/H) in fresh and marine water is 132-156 µg/g (ppm) [7,8].Since the mass of protium H is half of the mass of deuterium D, effects arising from the replacement of isotopes influence biological systems; for example, the rates of chemical reactions between substances containing these isotopes may differ by a factor of 5-10 [9-11].Numerous publications over the last 20 years have been devoted to the study of the role of deuterium in natural (150 ppm) or reduced content in the human body [12]. It has been shown that deuterium-depleted water (DDW) exhibits antidotal properties with individual and combined effects on the dosage of pharmaceutical substances and auxiliary substances [13][14][15][16]. The mechanisms of such influence are due to the structure, physicochemical properties of DDW [17] and changes in ligand-receptor interactions in biological objects of different hierarchical levels [18]. DDW increases the rate of photosynthesis and promotes the growth of plants and aquatic animals [19,20]. In Europe, the USA, Japan, China and Russia, DDW is used for prophylactic and therapeutic purposes [21,22]. Currently, DDW is using as an adjuvant in cancer treatment ...

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Section: Discussionsupporting

confidence: 53%

Deuterium-Depleted Water as Adjuvant Therapeutic Agent for Treatment of Diet-Induced Obesity in Rats

et al. 2019

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“…The artificial urine recipe was prepared according to Shiotsuki et al 22 (Table S1, SI). Zn, Cd and Se with natural isotopic compositions were also added into the solution to obtain the average concentrations found in human urine of 650, 0.2 and 40 ppb, respectively [11][12][13] .…”

Section: Methodsmentioning

confidence: 99%

“…650, 0.2 and 40 ppb of Zn, Cd and Se and human blood plasma contains ca. 1000, 0.3 and 100 ppb, respectively [11][12][13] . Therefore, during fate and/or toxicity studies, it is crucial to distinguish the trace metals naturally present in the matrix from the ones originated from the QDs.…”

mentioning

confidence: 99%

Tracing multi-isotopically labelled CdSe/ZnS quantum dots in biological media

Supiandi

Charron

Tharaud

et al. 2020

Sci Rep

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the strengths and limits of isotopically labelled engineered nanoparticles (spiked enps) spread in biological media have been assessed. Multi-spiked CdSe/ZnS quantum dots (QDs), measuring 7 nm and coated with thioglycolic acid (tGA), were synthesized and enriched in 68 Zn, 77 Se and 111 cd. these QDs were dispersed at very low concentrations (0.1 to 5000 ppt) in diverse biological matrices (synthetic saliva, synthetic urine, plasma and Dulbecco's phosphate buffered saline -DPBS growth medium) and the isotopic compositions were determined by HR-icp-MS. the initial QDs concentrations were calculated to assess the limit of quantification (QD-LOQ) according to the matrix and the isotopically enriched element. the obtained results demonstrated the advantages of the isotopic labelling method in order to work at very low concentrations: the QD-LOQ values for the spiked Zn, Cd and Se originated from the QDs were 10, 0.3 and 6 ppt, respectively, which is below the conventional LOQ of the HR-ICP-MS used (30, 3 and 60 ppt for Zn, Cd and Se, respectively). Conversely, in complex matrices such as saliva, urine, plasma and DPBS growth medium, the QD-LOQ values increased significantly, with values ranging from 16 to 32 ppt for Cd, 446 to 10598 ppt for Zn and 1618 to 8317 ppt for Se. These QD-LOQs are dependent on factors as the elemental background concentration already present in the matrices, and the dilution factor. In this study, the QD-LOQs are expressed for the first time with respect to the background concentration in biological media (QD-RLOQ), which can be used to better assess and then predict the efficiency of the spiking method.

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“…No report of cobalt deficiency in normal individuals fed a balanced diet has been documented. However, it has been reported that obese children might have abnormally low levels of Co in their blood and may need supplementation [66].…”

Section: Exposure and Metabolism Of Comentioning

confidence: 99%

Chapter 5: Microelements: Part II: F, Al, Mo and Co

Zohoori

Duckworth

2019

Monographs in Oral Science

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Ultratrace element is a relatively new term defined as those elements with an established, estimated, or suspected dietary requirement of minute amount, generally of the order of µg/day. This chapter focuses on fluorine (F), aluminium (Al), molybdenum (Mo) and cobalt (Co). Whilst diet is the principal source of Al, Mo and Co found in the body, inadvertent ingestion of dental hygiene products accounts for a significant proportion of F intake. Apart from fluorine, the influence of other ultratrace elements on oral health, and in particular dental caries, has not been fully established. The calcified tissues contain 99% of body F. During tooth development, ingested (systemic) F is incorporated into the apatite crystals of the developing tooth which helps in improving resistance to acid demineralisation. However, the presence of low but constant levels of topical F in the fluid phase at the tooth enamel surface are more important in controlling tooth decay for people of all ages. An adequate intake (AI), from all dietary and non-dietary sources, is estimated as 0.05 mg/kg body weight/day for children older than 6 months and adults, based on estimated intakes that have been shown to reduce the incidence of dental caries while minimising adverse health effects such as dental fluorosis. An inverse relationship between incidence of dental caries and levels of Al in drinking water, food and soils has been indicated by some epidemiological studies. Co and Mo, whilst occasionally showing potential beneficial oral health effects in laboratory experiments, do so at concentrations much higher than found in vivo.

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Differences in Trace Metal Concentrations (Co, Cu, Fe, Mn, Zn, Cd, and Ni) in Whole Blood, Plasma, and Urine of Obese and Nonobese Children

Cited by 77 publications

References 46 publications

Deuterium-Depleted Water as Adjuvant Therapeutic Agent for Treatment of Diet-Induced Obesity in Rats

Deuterium-Depleted Water as Adjuvant Therapeutic Agent for Treatment of Diet-Induced Obesity in Rats

Tracing multi-isotopically labelled CdSe/ZnS quantum dots in biological media

Chapter 5: Microelements: Part II: F, Al, Mo and Co

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