Differences in tissue proliferation and maturation between Matrix2 and bare platinum coil embolization in experimental swine aneurysms

Histological and Transmission Electron Microscopy Results after Embolization with HydroSoft/HydroFrame Coils in Experimental Swine Aneurysm

“…Although we previously compared Matrix2 with bare platinum coils [8], we only compared hydrogel coils and bare platinum coils in the present study. Because several endovascular approaches are now available for the treatment of intracranial aneurysms, including standard coiling, balloon-assisted coiling, stent-assisted coiling, and flow diversion, Matrix2 coils are no longer frequently used in the clinical setting [35].…”

“…Cineangiography was performed to ensure that no major bleeding or leakage from the anastomosis occurred before reestablishment of blood flow [22]. This study used the method described by Mitome-Mishima et al [8], and their wording is partly reproduced in Materials and Methods.…”

“…New-generation coils have been developed with polymer-platinum hybrid devices, degradable polymers, and expansible polymers. Matrix2 (Boston Scientific, Marlborough, MA, USA) is a degradable polymer device that was evaluated by Mitome-Mishima et al [8] in a swine experimental aneurysm model. Expansible polymer devices have been developed because the increased volume of embolic devices within the aneurysm sac may provide better stability for thrombus organization [9].…”