Differences in the Tensor Veli Palatini Between Adults With and Without Cleft Palate Using High-Resolution 3-Dimensional Magnetic Resonance Imaging

George, T. Neville; Kotlarek, Katelyn J.; Kuehn, David P.; Sutton, Bradley P.; Perry, Jamie L.

doi:10.1177/1055665617752802

Cited by 13 publications

(17 citation statements)

References 37 publications

(65 reference statements)

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“…Future studies may also consider the influence of nonanatomic factors such as immunologic profiles, which may also influence the frequency or severity of middle ear disease in 22q11DS. A difference between findings in the present study among children with 22q11DS compared to past reports of individuals with repaired cleft palate (George et al, 2018) was the difference in the bihamular width. George et al (2018) reported no significant differences in bihamular width between adults with and without cleft palate.…”

Section: Discussioncontrasting

confidence: 99%

“…A difference between findings in the present study among children with 22q11DS compared to past reports of individuals with repaired cleft palate (George et al, 2018) was the difference in the bihamular width. George et al (2018) reported no significant differences in bihamular width between adults with and without cleft palate. In the present study, participants with 22q11DS demonstrated a significantly greater bihamular distance, on average 3 mm greater than that of control participants.…”

Section: Discussioncontrasting

confidence: 99%

“…The TVP muscle was visualized by slicing the 3D data along an oblique coronal plane at an angle that allowed for the muscle bellies to be displayed fully from the origin to the insertion. Sequential slices were used to create a 3D volumetric reconstruction of the muscle, as described by Perry et al (2013), Kotlarek et al (2017), and George et al (2018). A free-handed paintbrush tool in Amira segmentation editor was used to identify TVP muscle fibers, thereby creating a voxel set.…”

Section: Image Analyses and Data Collectionmentioning

confidence: 99%

“…However, no studies have examined whether the TVP abnormalities observed in individuals with cleft palate are also found in individuals with 22q11DS. In addition, the report by George et al (2018) did not include detailed audiologic or otologic histories of adult participants. As a result, it is unclear whether abnormalities of the TVP directly relate to middle ear health.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, we compared differences between groups regarding the hamular process width. Because hypoplasia of the TVP muscle has been observed in adults with repaired cleft palate (George et al, 2018), it was hypothesized that hypoplasia in the TVP muscle would also be observed among this clinical population. We expected TVP muscle hypoplasia to be accompanied by a smaller total muscle volume.…”

Section: Introductionmentioning

confidence: 99%

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Differences in the Tensor Veli Palatini Muscle and Hearing Status in Children With and Without 22q11.2 Deletion Syndrome

Perry

Kotlarek

Spoloric

et al. 2019

The Cleft Palate-Craniofacial Journal

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Purpose: To investigate the dimensions of the tensor veli palatini (TVP) muscle using high image resolution 3-dimensional magnetic resonance imaging (MRI) of the soft palate among children with normal velopharyngeal and craniofacial anatomy and to compare values to individuals with a diagnosis of 22q11.2 deletion syndrome (22q11DS). We also sought to determine whether there is a relationship between hypoplasia of the TVP and severity of middle ear dysfunction and hearing loss. Methods: Three-dimensional MRI were used to collect and analyze data obtained across 53 children between 4 and 12 years of age, including 40 children with normal velopharyngeal and craniofacial anatomy and 13 children with a diagnosis of 22q11.2 DS. Tensor veli palatini muscle length, thickness, and volume as well as bihamular distance were compared among participant groups. Results: A Welch’s t-test revealed that the TVP in participants with 22q11DS is significantly shorter ( P = .005, 17.3 vs 19.0 mm), thinner ( P < .001, 1.1 vs 1.8 mm), and less voluminous ( P < .001, 457.5 vs 667.3 mm3) than participants without 22q11DS. Participants with 22q11DS also had a greater ( P = .006, 27.7 vs 24.7 mm) bihamular distance than participants without 22q11DS. There was an inverse relationship between TVP abnormalities noted above and the severity of audiologic and otologic histories. Conclusion: The TVP muscle is substantially reduced in volume, length, and thickness in children with 22q11DS. These findings serve as preliminary support for the association of patient hearing and otologic severity and TVP dysmorphology.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Section: Image Analyses and Data Collectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Differences in the Tensor Veli Palatini Muscle and Hearing Status in Children With and Without 22q11.2 Deletion Syndrome

Perry

Kotlarek

Spoloric

et al. 2019

The Cleft Palate-Craniofacial Journal

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Prevalence of Tympanostomy Tube Placement in Relation to Cleft Width and Type

et al. 2021

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Objectives/Hypothesis: The prevalence of tympanostomy tube surgery (TTS) in patients with a cleft deformity was investigated, in relation to cleft width and cleft type.Study Design: Retrospective review of medical health records. Methods: Retrospective review of medical health records. Seventy-eight patients with non-syndromic cleft deformity of the palate and/or alveolus and lip between 2003 and 2017 were investigated. All available medical documents were analyzed. The study group was divided into subgroups: 1) patients with isolated cleft palate (CP) and patients with a cleft palate with cleft lip and alveolus (CLP). 2) According to Veau's classification (I-IV), further subgroups were defined. Cleft width was measured using plaster cast models.Results: TTS was performed in 55% of the patients (n = 43). Considering Veau's classification, TTS was conducted as follows: Veau I 65.2% (n = 15/23), Veau II 55.0% (n = 11/20), Veau III 47.6% (n = 10/21), and Veau IV 50.0% (n = 7/14). Cleft classifications, maxillary arch width, and absolute/relative cleft width had no statistical impact on TTS occurrence. Although no significant correlation could be found, patients in our study group with CP (Veau I and II) underwent TTS more often (60.5%, n = 26/43) than patients with CPL (Veau III and IV; 48.6%, n = 17/35) during a three-year follow-up.Conclusion: None of the cleft characteristics examined had a significant impact on the proportion of patients who received TTS. Nevertheless, patients with lower Veau classification and CP received tympanostomy tubes more often. Therefore, otolaryngologists and pediatricians treating children with cleft palate should maintain a high level of suspicion for chronic middle ear effusion, even in patients with small clefts.

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Modern Cleft Palate Repair: Controversies, Surgical Techniques, and Postoperative Care

Denadai¹,

2022

Current Concept in Cleft Surgery

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Differences in the Tensor Veli Palatini Between Adults With and Without Cleft Palate Using High-Resolution 3-Dimensional Magnetic Resonance Imaging

Cited by 13 publications

References 37 publications

Differences in the Tensor Veli Palatini Muscle and Hearing Status in Children With and Without 22q11.2 Deletion Syndrome

Differences in the Tensor Veli Palatini Muscle and Hearing Status in Children With and Without 22q11.2 Deletion Syndrome

Prevalence of Tympanostomy Tube Placement in Relation to Cleft Width and Type

Modern Cleft Palate Repair: Controversies, Surgical Techniques, and Postoperative Care

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