Differences in the Severity of Adjuvant Arthritis in Four Strains of Rats

Swingle, Karl F.; Jaques, Laura; Kvam, Donald C.

doi:10.3181/00379727-132-34270

Cited by 39 publications

(21 citation statements)

References 3 publications

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“…Concerning adjuvant arthritis strain differences are well-known in outbred rats [15] and in inbred rats [9,11]. Our results confirm the observation of Perlik et al [9] that WAG rats are relatively resistant to AA, while LEW and LE develop a severe disease.…”

Section: Discussionsupporting

confidence: 88%

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Adjuvant-induced arthritis in four inbred strains of rats. An in vitro study of peripheral T and B lymphocytes

Kahan

Perlı́k

et al. 1976

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The lymphoblastic response (LTT) to non-specific mitogens (PHA, PWM and ConA) of peripheral lymphocytes was investigated at days 0, 7, 14, 21 and 28 after adjuvant injection in four strains of inbred rats: Wistar (WAG), Long Evans (LE), Lewis (LEW) and Brown Norway (BN). LTT was assessed by using 18 hours H3 TdR incorporation in 5 days cultures of whole blood (micromethod). The statistical treatment of data, using principal components multifactorial analysis and analysis of variance showed a striking difference between strains. In control animals the responses to PHA and PWM were correlated and were higher in LE and WAG than in LEW and BN (BN=LEW less than LE=WAG). The response to ConA was independent of that to the other mitogens. It was generally low, but significantly higher in LEW and BN than in WAG and LE. In adjuvant-injected animals the responses to PHA and PWM were still correlated, but modified compared to control: in LE and LEW, but not in WAG and BN, a marked decrease of the response was found, reaching a minimum value within days 7 and 14. In the same time the response to ConA increased in the four strains, later in LE than in the others. However the intensity of the ConA response varied from one strain to another: it was constantly low in LE and WAG compared to LEW and BN. So the most striking modification of LTT were observed in LE and LEW, which both developed the most severe arthritis. However these different behaviours after adjuvant injection were not explained by the initial level of LTT to the different mitogens. These data suggest that the development of intense arthritis is associated with the proliferation and the release into the blood stream of a lymphocyte subpopulation, which exhibits a low response to PHA and PWM and a high response to ConA. These LTT modifications are not paralleled by quantitative variations of B-cells assessed by surface Ig immunofluorescent staining and EAC rosetting.

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Section: Discussionsupporting

confidence: 88%

“…However, significant strain differences in the frequency and the severity of arthritis were observed, either in outbred [11,15] or in inbred animals [9,11], in the later ones a multifactorial type of inheritance was suggested [9].…”

mentioning

confidence: 99%

Adjuvant-induced arthritis in four inbred strains of rats. An in vitro study of peripheral T and B lymphocytes

Kahan

Perlı́k

et al. 1976

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“…In other animal models of rheumatoid arthritis differences are found between spec ies and also between strains of animals in their susceptibility to the induction of joint lesions [Swingle et al, 1969]. Varying in cidence of lesions in groups from different sources found in our study may be due to environmental or genetic factors.…”

Section: Discussionsupporting

confidence: 44%

Early Rheumatoid-Like Lesions in Rabbits Injected with Foreign Serum: Relationship to Localization of Immune Complexes in the Lining Tissues of Joints and Cellular Content of Synovial Fluid

Poole¹,

Oldham²,

Coombs³

1978

Int Arch Allergy Immunol

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Immune complex localization in joint tissues and white cell effusion into the joint space as well as synovial lesions are shown to occur in rabbits injected intravenously with bovine serum. Synovial lesions of one knee were found to be associated with immune complexes in joint tissues of the contralateral knee (because of the experimental design very few rabbits had both immunofluorescence and histology performed on the same joint). There was also a week correlation between moderate and gross synovial lesions and cellular effusions of the same joint. Cartilage proteoglycan depletion was seen in some injected animals and this was related to lining cell hyperplasia. Rabbits from different breeding colonies displayed different incidences of lesions suggesting an environmental or genetic influence on the development of rheumatoid-like lesions.

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“…There is accumulating evidence for a genetical link to the susceptibility to adjuvant-induced arthritis [Swingle et al, 1969;Rosenthal, 1970;Currey, 1970;Kahan et al, 1976] and EAE [Paterson and Harwin, 1963;Levine and Wenk, 1961;Hughes and Stedronska, 1973] in rats.…”

Section: Discussionmentioning

confidence: 99%

Susceptibility of Two Colonies of Wistar Rats to Inflammation, with Particular Reference to Delayed Hypersensitivity

Brito¹,

Hanahoe²

1983

Int Arch Allergy Immunol

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Two colonies of Wistar rats were tested for their abilities to produce delayed hypersensitivity reactions and other forms of inflammation. Tuck rats, which respond to dextran with an anaphylactoid reaction, produced delayed reactions to tuberculin protein and to ovalbumin in Freund’s incomplete adjuvant. On the other hand, NELP rats which do not respond to dextran also produced delayed reactions to tuberculin protein, but only to ovalbumin when this was contained in Freund’s complete adjuvant. Rats of both colonies responded to cotton pellet-induced inflammation, but the adult NELP rats showed resistance both to adjuvant-induced and to collagen-induced arthritis, as well as to the production of experimental allergic encephalomyelitis. NELP rats also showed a much greater reticulo-endothelial system phagocytic activity although antibody titres to sheep red blood cells and the mitogenic activity of concanavalin A and of lipopolysaccharide on spleen cells were similar in the two colonies of rats.

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Differences in the Severity of Adjuvant Arthritis in Four Strains of Rats

Cited by 39 publications

References 3 publications

Adjuvant-induced arthritis in four inbred strains of rats. An in vitro study of peripheral T and B lymphocytes

Adjuvant-induced arthritis in four inbred strains of rats. An in vitro study of peripheral T and B lymphocytes

Early Rheumatoid-Like Lesions in Rabbits Injected with Foreign Serum: Relationship to Localization of Immune Complexes in the Lining Tissues of Joints and Cellular Content of Synovial Fluid

Susceptibility of Two Colonies of Wistar Rats to Inflammation, with Particular Reference to Delayed Hypersensitivity

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