Differences in the ARID‐1 alpha expressions in squamous and adenosquamous carcinomas of uterine cervix

Abstract

AT-rich interactive domain 1A (ARID1A) is a tumor suppressor gene involved in chromatin remodeling which encodes ARID1A (BAF250a) protein. Recent studies have shown the loss of ARID1A expression in several types of tumors. This retrospective study was designed to evaluate the differences in tissue expressions of ARID1A in a spectrum of cervical neoplasms. Cervical intraepithelial neoplasms, invasive squamous or adenosquamous carcinomas were identified in 100 patients recently diagnosed as cervical neoplasms based on pathology databases. In this series, there were 29 low- and 29 high-grade cervical intraepithelial neoplasms, 27 squamous cell carcinomas, and 15 adenosquamous carcinomas. Mean age of the patients was 47.8 ± 13 years (20-80 years). It was determined that the expression of ARID1A was statistically significantly down-regulated in adenosquamous carcinomas when compared with non-invasive or invasive squamous cell carcinomas (p = 0.015). Lower levels of the ARID1A expression were detected in cases with adenosquamous carcinomas (60%), low- or high-grade squamous intraepithelial lesion (SIL) (31%), and squamous cell carcinomas (18.5%). Our findings have demonstrated the presence of a correlation between ARID1A expression and adenomatous differentiation of uterine squamous cell carcinomas. Therefore, ARID1A gene may suggestively have a role in the pathogenesis of cervical adenosquamous carcinomas.

Tissue expression of human epididymal secretory protein 4 may be useful in the differential diagnosis of uterine cervical tumors

“…In spite of frequent implementation of screening programs, uterine cervical cancers are still one of the main causes of cancer mortality among female population around the world [9,10]. Squamous cell carcinoma (SCC) is the most frequent histological type accounting for 75-80% of invasive uterine cervical carcinomas [9][10][11].…”

“…Squamous cell carcinoma (SCC) is the most frequent histological type accounting for 75-80% of invasive uterine cervical carcinomas [9][10][11]. Adenosquamous carcinomas (ASCs) can be defined as tumors that contain a mixture of malign squamous and glandular cells.…”

“…The prevalence of ASC is higher particularly in young women. It metastasizes to pelvic lymph nodes twice as frequently as SCC or adenocarcinomas [8][9][10]. Most authors have reported a poorer prognosis for patients with ASCs.…”

“…Other type is pure adenocarcinoma (AC) of the uterine cervix. Squamous and glandular components of cervical cancers are monoclonal in origin and arise from the pluripotent subcolumnar reserve cells of the endocervical mucous epithelium [8][9][10][11].…”

Hypoxia-inducible factor 1 alpha expression is an indicator of invasiveness in uterine cervical tumors

“…3 Squamous cell carcinoma (SCC) is the most frequently seen histologic type which constitutes 75-80% of invasive cervical carcinomas. [4][5][6] Adenosquamous cell carcinoma (ASC) is the 2. most frequently seen (3.6-25%) cervical carcinoma whose prevalence is higher in young women. 6,7 Another type of cervical cancer is pure adenocarcinoma (AC).…”