Differences in the relationships between coronary blood flow and myocardial clearance of isotopes of potassium, rubidium, and cesium

Love, William D.; Ishihara, Yasushi; Lyon, LeonardJ.; Smith, Rebekah E.

doi:10.1016/0002-8703(68)90230-5

Cited by 31 publications

(9 citation statements)

References 7 publications

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“…Theoretically this disadvantage is eliminated by the method of MBF determination using radioisotopes of potassium, rubidium or caesium. A good agreement of MBF values measured by 86 Rb uptake and other methods was described in patients (19) and in experiments on dogs without regional ischemia (14). The results of our study indicate that this method has a number of limitations judging by the relatively high 8 6 Rb concentration in the necrotic area; this fact may be explained by the changed extraction coefficient of 86 Rb in the necrotic tissue.…”

Section: Discussionsupporting

confidence: 80%

The Validity of the Total Myocardial Blood Flow Determination by Means of 113Xe in Regional Ischemia

Kasalický¹

1976

Nuklearmedizin

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SummaryRegional MBF in the ischemic and healthy left ventricular myocardium was measured in 21 mongrel dogs by means of locally injected 133Xe and its washout one week after ligation of the left anterior descending coronary. Simultaneously the total MBF was calculated from the precordial washout determination of 133Xe injected into the left coronary artery. The 133Xe measurements were compared with the regional 86Rb uptake. The values of total MBF determination after left coronary artery injection did not diminish adequately to the size of the ischemic area; these values were usually higher as compared with the calculated mean MBF evaluated from the regional left ventricular blood flow and did not agree with regional MBF in the intact left ventricular myocardium. The difference of perfusion between the necrotic and the healthy left ventricular myocardium determined from the local 133Xe washout was higher in comparison to 86Rb uptake. The method of total MBF determination by means of precordially determined 133Xe washout injected into the coronary artery yields artificially higher values in cases with greater ischemic areas. This may be accounted for by a low initial radioactivity of the hypoperfused areas and their negligible contribution to the total radioactivity changes produced predominantly by the well perfused areas. The relatively low 86Rb uptake difference in the healthy and the necrotic left ventricular myocardium may be caused by affected extraction coefficients of 86Rb in the necrotic tissue.

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Section: Discussionsupporting

confidence: 80%

The Validity of the Total Myocardial Blood Flow Determination by Means of 113Xe in Regional Ischemia

Kasalický¹

1976

Nuklearmedizin

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“…(79, 80). Love et al (81) later showed that only 22% of cesium 134 in arterial blood was removed during one passage through the heart, a value considerably less than that obtained with potassium and rubidium and supportive of earlier work on erythrocytes, which demonstrated that cesium 134 entered red blood cells more slowly than potassium or rubidium (82). Love et al (81) later showed that only 22% of cesium 134 in arterial blood was removed during one passage through the heart, a value considerably less than that obtained with potassium and rubidium and supportive of earlier work on erythrocytes, which demonstrated that cesium 134 entered red blood cells more slowly than potassium or rubidium (82).…”

Section: Cold Spot Imagingmentioning

confidence: 75%

Radiopharmaceuticals Used in Myocardial Imaging

Mills

Basmadjian

Ice

1981

Journal of Pharmaceutical Sciences

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“…The myocardial extraction fraction of 8~Rb is similar to that of 2°~T1 and potassium-43 [22]. Peak myocardial uptake of rubidium occurs approximately 5 min after injection, and the washout kinetics are comparable to those observed for potassium [23,24]. Previously, myocardial perfusion imaging with 8~Rb in conventional nuclear medicine was accomplished with a scintillation camera using a planar technique and a pinhole collimator and a lead shield to prevent penetration of the collimator by the high-energy emission of 81Rb [25,26].…”

Section: Discussionmentioning

confidence: 98%

Single-photon emission tomography studies of rubidium-81 in the detection of ischaemic heart disease, using a stress-reinjection protocol

Botsch¹,

Beringer²,

Petersen

et al. 1994

Eur J Nucl Med

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The present study was designed to determine the feasibility of using single-photon emission tomography (SPET) imaging with rubidium-81 (T1/2 = 4.54 h) to detect ischaemic heart disease, using a stress-reinjection protocol and a specially constructed 511-keV hexagonal hole collimator for a standard gamma camera. The diagnostic performance of 81Rb SPET in detecting coronary artery disease (CAD) was investigated in 52 patients with a high prevalence of CAD. Coronary arteriography was performed in 34 patients, 25 of whom were classified as having significant stenosis (> or = 50%). At peak exercise (Cornell protocol), 111-222 MBq 81Rb was injected i.v. for stress imaging, and after 3 h of rest, 74-111 MBq was reinjected for rest imaging. The displayed short- and long-axis slices and the polar map images were interpreted qualitatively. In comparison to coronary arteriography, which served as the gold standard, the performance of 81Rb SPET revealed a sensitivity of 95% for the detection of CAD. Images of diagnostic quality were obtained in all patients, these being comparable to thallium-201 SPET images. In conclusion, these results indicate that the described method can be routinely used for the positron emitter 81Rb with a conventional gamma camera and special shielding. 81Rb has the well-known advantages of a potassium analogue and 81Rb SPET permits better visualization, particularly of the posterior wall of the myocardium, due to the higher photon energy. Considering the typical dose of 201Tl used for SPET (74-148 MBq), a 81Rb SPET scan imposes a significantly lower radiation burden on the patient.

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Differences in the relationships between coronary blood flow and myocardial clearance of isotopes of potassium, rubidium, and cesium

Cited by 31 publications

References 7 publications

The Validity of the Total Myocardial Blood Flow Determination by Means of 113Xe in Regional Ischemia

The Validity of the Total Myocardial Blood Flow Determination by Means of 113Xe in Regional Ischemia

Radiopharmaceuticals Used in Myocardial Imaging

Single-photon emission tomography studies of rubidium-81 in the detection of ischaemic heart disease, using a stress-reinjection protocol

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