Differences in the prevalence of erectile dysfunction between novel subgroups of recent-onset diabetes

Maalmi, Haïfa; Herder, Christian; Bönhof, Gidon J.; Straßburger, Klaus; Zaharia, Oana‐Patricia; Rathmann, Wolfgang; Burkart, Volker; Szendroedi, Julia; Roden, Michael; Ziegler, Dan

doi:10.1007/s00125-021-05607-z

Cited by 22 publications

(9 citation statements)

References 48 publications

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“…Multiple studies showed similar findings with a possibility of bidirectional relationship between both T2D and depression. 14 , 25 , 26 …”

Section: Discussionmentioning

confidence: 99%

Erectile Dysfunction and Depression Prevalence Among Male Patients with Type II Diabetes

Alswat,

Almorgi,

Aljardahi

et al. 2024

JMDH

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Background and Objective Patients with Type 2 Diabetes (T2D) are at substantial risk for developing erectile dysfunction (ED). The primary goal of this study was to assess the prevalence of ED and depression among T2D patients and the associated risk factors. Methods A cross-sectional study was conducted for adult T2D patients who had a routine clinic visit between January–August 2023. Structured questionnaires formed with two validated questionnaires – the International Index of Erectile Function short form (IIEF-5) and Patient Health Questionnaire (PHQ-9) – were used to screen for ED and depression, respectively. Results A total of 478 male patients with T2D with a mean age of 59.2 ± 10.8 years, mostly married, with long standing T2D were included. Hyperlipidemia followed by hypertension were the most reported comorbidities. Of the patients, 61.3% had reported no depression and were less likely to have ED or severe ED ( p <0.001) and more likely to be physically active and to report no smoking ( p <0.0001) when compared to those with depression. Fifty-two percent of the patients reported moderate and severe ED and those were older in age ( p = 0.031), had longer duration of T2D diagnosis ( p = 0.005), were more likely to have any comorbidities ( p <0.05), were less likely to have a university degree and higher income (both p <0.001), were less likely to be on oral hypoglycemic agents (OHA) ( p <0.001), had worse glycemic control parameters ( p = 0.463), were more likely to have positive urine microalbuminuria ( p = 0.019), and were less likely to be physically active ( p = 0.048) when compared to patients with no or milder degree of ED. Conclusion ED is highly prevalent in our study sample, with half of the patients having moderate to severe ED and being more likely to have depression. Older age, long-standing T2D, comorbidities, socioeconomic disadvantage, and sedentary lifestyle were all significantly associated with ED.

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“…Multiple studies showed similar findings with a possibility of bidirectional relationship between both T2D and depression. 14 , 25 , 26 …”

Section: Discussionmentioning

confidence: 99%

Erectile Dysfunction and Depression Prevalence Among Male Patients with Type II Diabetes

Alswat,

Almorgi,

Aljardahi

et al. 2024

JMDH

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“…6,7 For example, individuals with recent-onset type 2 diabetes (diabetes duration ≤1 year) had an increased risk of distal sensorimotor polyneuropathy (DSPN) if they were severely insulin deficient, 8 while those who were either insulin resistant or insulin deficient had an increased risk of erectile dysfunction (ED), a frequent manifestation of autonomic neuropathy in diabetes. 9 Of note, a recent meta-analysis reported that ED is associated with prediabetes independent of the men's age. 10 Further evaluation of the present approaches and novel integrated methods to redefine diabetes subtypes will be required to determine when and how best to introduce these approaches into clinical practice.…”

Section: Prediabetes: Classification Epidemiology Impact and Screenin...mentioning

confidence: 99%

“…In this context, the recent years have witnessed efforts to introduce novel diabetes subgroup categories to refine the classification of diabetes beyond the current definition of diabetes types aimed at optimising the risk stratification and treatment in terms of precision medicine to ultimately improve patient outcomes 6,7 . For example, individuals with recent‐onset type 2 diabetes (diabetes duration ≤1 year) had an increased risk of distal sensorimotor polyneuropathy (DSPN) if they were severely insulin deficient, 8 while those who were either insulin resistant or insulin deficient had an increased risk of erectile dysfunction (ED), a frequent manifestation of autonomic neuropathy in diabetes 9 . Of note, a recent meta‐analysis reported that ED is associated with prediabetes independent of the men's age 10 …”

Section: Prediabetes: Classification Epidemiology Impact and Screeningmentioning

confidence: 99%

Neuropathy in prediabetes

Ziegler

Herder

Παπάνας

2023

Diabetes Metabolism Res

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Diabetic neuropathies are the most frequent complications of diabetes, contributing to high morbidity, excess mortality, reduced quality of life, and increased healthcare costs. Prediabetes is characterised by glucose levels within an intermediate range above normoglycaemia yet below the diagnostic threshold for diabetes. In 2021, 10.6% and 6.2% of adults worldwide were estimated to have impaired glucose tolerance and impaired fasting glucose, respectively, the majority of whom are unaware of having prediabetes. Evidence has accumulated suggesting that prediabetes is a predictor of cardiovascular disease (CVD) and increased mortality. The past 2 decades have witnessed an extensive debate, particularly among diabetologists and neurologists, as to whether prediabetes is associated with peripheral neuropathy. In this review, we elaborate on the current evidence, particularly from population‐based studies supporting an increased risk of distal sensorimotor polyneuropathy (DSPN) and cardiovascular autonomic neuropathy (CAN) in people with prediabetes. Moreover, we discuss whether lifestyle interventions showing efficacy in preventing or delaying the transition from prediabetes to diabetes in persons with prediabetes may also exert favourable effects on the development and progression of DSPN and CAN. This review should help in raising the awareness of and translating the current knowledge on neuropathies in people with prediabetes into clinical practice and public health. The current recommendation that adults who are overweight or obese should be screened for prediabetes and referred to or offered preventive interventions should ultimately culminate in preventing not only CVD but also prediabetic neuropathy.

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“…Differences in the aetiology of sexual dysfunction in T1DM and T2DM have been postulated from the well‐documented differences in ED in observational studies 127 and a recent meta‐analysis 4 between these two cohorts of diabetic men. It is known that the pathogenesis in T1DM is that of insulin deficiency, which may have an autoimmune aetiology, hence, tends to present at a younger age, whereas T2DM is largely attributable to the metabolic syndrome and insulin resistance.…”

Section: Possible Predictors Of Ejd In Dmmentioning

confidence: 99%

Understanding and treating ejaculatory dysfunction in men with diabetes mellitus

et al. 2022

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Differences in the prevalence of erectile dysfunction between novel subgroups of recent-onset diabetes

Cited by 22 publications

References 48 publications

Erectile Dysfunction and Depression Prevalence Among Male Patients with Type II Diabetes

Erectile Dysfunction and Depression Prevalence Among Male Patients with Type II Diabetes

Neuropathy in prediabetes

Understanding and treating ejaculatory dysfunction in men with diabetes mellitus

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