Differences in the Pattern of Antibiotic Prescription Profile and Recurrence Rate for Possible Urinary Tract Infections in Women With and Without Diabetes

Schneeberger, Caroline; Stolk, Ronald P.; DeVries, J. Hans; Schneeberger, Peter M.; Herings, Ron M. C.; Geerlings, Suzanne E.

doi:10.2337/dc07-2188

Cited by 45 publications

(36 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Anatomic and functional abnormalities of the urinary tract are also associated with diabetes, and these abnormalities complicate UTI [10]. A Dutch study showed that despite the fact that patients with diabetes more often received longer and more potent initial treatment than patients without diabetes, women with diabetes more often had recurrences of their UTIs [11]. However, there is limited information on the prevalence and recurrence of UTI and genital infection among diabetes patients in the United States.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and recurrence of urinary tract and genital infections among adults with and without type 2 diabetes mellitus in the general population: a longitudinal cohort study

Grandy¹,

Fox²,

Hardy³

2013

J Diab Res Clin Met

View full text Add to dashboard Cite

Background: This study estimated the prevalence, recurrence, and predisposing factors of self-reported urinary tract infections (UTIs) and genital infections among adults with and without type 2 diabetes mellitus (T2DM). Methods: In the US Study to Help Improve Early evaluation and management of risk factors Leading to Diabetes (SHIELD) 2008 survey, respondents reported how many times in the past 12 months they had a UTI or genital infection. T2DM respondents were compared with respondents who did not have diabetes (No DM). T2DM respondents who reported 3 or more infections were classified as having recurrent infections and were compared with T2DM respondents who reported 1-2 infections (non-recurrent infections) and those without infections. Results: The prevalence rate of UTI was 184.4/1000 for T2DM and 127.8/1000 for No DM among women (p <0.001), and 50.9/1000 for T2DM and 33.9/1000 for No DM among men (p = 0.02). Odds of experiencing a UTI were 1.5 times higher among T2DM respondents than No DM respondents. For T2DM respondents with UTI, 23% reported recurrent UTIs, largely among women. Predictors of recurrent UTIs compared with no UTIs in women were overactive bladder, kidney problems, atherosclerosis, and COPD. Among men, the prevalence rate of balanitis was 41.8/1000 for T2DM and 19.2/1000 for No DM (p <0.01). Prevalence rate of vaginitis was 172.6/1000 for T2DM and 125.0/1000 for No DM (p <0.01). Odds of vaginitis were 1.9 and balanitis were 2.3 times higher among T2DM than no DM respondents. Among T2DM women with vaginitis, 30% reported recurrent vaginitis. Lower education, receiving oral anti-diabetic drugs plus insulin, and atherosclerosis predicted recurrent vaginitis compared with non-recurrent vaginitis. Conclusions: UTIs and genital infections were more prevalent with T2DM than among respondents without diabetes. Recurrent infections occur in approximately 23%-30% of adults. Select characteristics may assist in identifying those likely to have self-reported recurrent infections.

show abstract

Section: Introductionmentioning

confidence: 99%

Prevalence and recurrence of urinary tract and genital infections among adults with and without type 2 diabetes mellitus in the general population: a longitudinal cohort study

Grandy¹,

Fox²,

Hardy³

2013

J Diab Res Clin Met

View full text Add to dashboard Cite

show abstract

“…In older-age categories, girls received more anti-infective prescriptions, which accords with the findings of Majed and Moser, which showed that prescribing rates for antibiotics in young females (older than 4 years) were substantially higher than in males of the same age (24). The increase in the prevalence and average number of anti-infective prescriptions in girls in older-age categories could be explained by a higher frequency of urinary tract infections (7). Increased susceptibility of patients with diabetes to vulvovaginal candidiasis could be the reason for the increased number of anti-infective prescriptions, especially antimycotics, as was observed in the oldest girls (25).…”

Section: Discussionmentioning

confidence: 95%

“…The higher consumption of anti-infective medications in children and adolescents with type 1 diabetes corresponds with the more frequent occurrence of infections in these patients (7,8). It is possible that regular contact with the physician after the diagnosis of type 1 diabetes increased the probability of diagnosing different infections, which resulted in prescribing more anti-infectives for these children during the follow-up time.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Population-Based Cohort Study of Anti-Infective Medication Use before and after the Onset of Type 1 Diabetes in Children and Adolescents

Farsani¹,

Souverein²,

Vorst³

et al. 2014

Antimicrob Agents Chemother

View full text Add to dashboard Cite

A population-based cohort study was conducted in the Dutch PHARMO database to investigate prevalence and patterns of antiinfective medication use in children and adolescents with type 1 diabetes (T1D) before and after the onset of this disease. All patients <19 years with at least 2 insulin prescriptions (1999 to 2009) were identified (T1D cohort) and compared with an age-and sex-matched (ratio: 1 up to 4) diabetes-free reference group. The prevalence and average number of anti-infective use was studied from (up to) 8 years before until a maximum of 4 years after the onset of T1D. A total of 925 patients with T1D and 3,591 children and adolescents in the reference cohort (51% boys, mean age of 10.1 [standard deviation, 4.5] years) were included. The overall prevalence of anti-infective use (62.6 compared to 52.6%, P < 0.001) and average number of prescriptions (2.71 compared to 1.42 per child, P < 0.001) in the T1D cohort were significantly higher than those in the reference cohort after the onset of diabetes. This pattern was consistent across sex and age categories and already observed in the year before the onset of type 1 diabetes. Patients in the T1D cohort received more antibacterials (49.8 compared to 40%, P < 0.001), antimycotics (4.0 compared to 1.3%, P < 0.001), antivirals (2.5 compared to 0.4%, P < 0.001), and second-line antibiotics, such as aminoglycosides, quinolones, and third-generation cephalosporins and carbapenems. Our findings that elevated anti-infective use in the T1D cohort exists in the period before the onset of type 1 diabetes and the consumption of more second-line anti-infective compounds in this time period warrant further research.

show abstract

“…1 According to a large Dutch study, 2 there is a high rate of recurrent UTIs in postmenopausal women (16.4%), rising to 19.1% in postmenopausal women with diabetes. The incidence in postmenopausal women is probably due to at least two factors: first, many postmenopausal women have urological issues such as incontinence, cystocele and postvoiding residual urine as a consequence of childbirth and loss of pelvic tone; and, secondly, low oestrogen levels YH Zhong, Y Fang, JZ Zhou et al…”

Section: Introductionmentioning

confidence: 99%

Effectiveness and Safety of Patient-Initiated Single-Dose versus Continuous Low-Dose Antibiotic Prophylaxis for Recurrent Urinary Tract Infections in Postmenopausal Women: A Randomized Controlled Study

et al. 2011

View full text Add to dashboard Cite

This study evaluated patient-initiated single-dose antibiotic prophylaxis and continuous long-term low-dose daily antibiotic use for the prevention of recurrent urinary tract infections (UTI) in 68 postmenopausal women. The women were randomized to take a low-dose antibiotic each night (continuous group, n = 37) or a single-dose antibiotic each time they experienced conditions predisposing to UTI (intermittent group, n = 31). During the 12-month study, 1.4 and 1.9 UTIs/patient developed in the continuous and the intermittent groups, respectively, which was significantly lower than the incidence of UTIs in the previous 12 months in these patients (4.7 and 5.1 UTIs/patient, respectively). The incidence of gastro intestinal adverse events was significantly lower in the intermittent group compared with the continuous group (9.1% versus 30.0%). In conclusion, patient-initiated single-dose intermittent antibiotic prophylaxis was as effective as low-dose daily antibiotic prophylaxis in the treatment of recurrent UTIs in postmenopausal women and was associated with fewer gastrointestinal adverse events.

show abstract

Differences in the Pattern of Antibiotic Prescription Profile and Recurrence Rate for Possible Urinary Tract Infections in Women With and Without Diabetes

Cited by 45 publications

References 19 publications

Prevalence and recurrence of urinary tract and genital infections among adults with and without type 2 diabetes mellitus in the general population: a longitudinal cohort study

Prevalence and recurrence of urinary tract and genital infections among adults with and without type 2 diabetes mellitus in the general population: a longitudinal cohort study

Population-Based Cohort Study of Anti-Infective Medication Use before and after the Onset of Type 1 Diabetes in Children and Adolescents

Effectiveness and Safety of Patient-Initiated Single-Dose versus Continuous Low-Dose Antibiotic Prophylaxis for Recurrent Urinary Tract Infections in Postmenopausal Women: A Randomized Controlled Study

Contact Info

Product

Resources

About