Differences in the Impact of Age on Mortality in Well-Differentiated Thyroid Cancer

Abstract

OS for PTC decreases incrementally with age, but OS for FTC decreases significantly in patients aged 45 years and older. A higher age threshold may inappropriately downstage some high-risk follicular cancer patients.

Cáncer de Tiroides: Descripción histopatológica de los pacientes diagnosticados en el Hospital San Juan de Dios - CCSS del 2010 al 2015

“…La incidencia según el tipo histológico encontrada en la presente investigación es similar a la reportada tanto en países latinoamericanos como Argentina y Colombia y en otras latitudes más , donde, en todos los casos, se evidencia un predominio de la histopatología papilar Según el tipo de cáncer de tiroides se observan variaciones en la edad al momento del diagnóstico. Específicamente en nuestro medio la edad al diagnóstico de cáncer anaplásico [27], folicular [28] y medular concuerda con las tendencias mundiales embargo, se evidencia diferencias en la edad del diagnóstico del linfoma tiroideo último caso, hay que tomar en cuenta que debido a los pocos casos reportados no se podría establecer esta edad como una tendencia.…”

The Age Threshold of the 8th Edition AJCC ClassificationIs Useful for Indicating Patients with Aggressive Papillary Thyroid Cancer in Clinical Practice.

“…The current 8 th Edition AJCC TNM classi cation system uses an age of 55 years as a cut-off point for risk strati cation in tumor staging (13). By contrast, the previous traditional TNM staging system used an age of 45 years (13) as a cut-off for staging, and the change to 55 years prompted a debate regarding how clinically well-founded this age cutoff point is for PTC risk strati cation, with some authors questioning the utility of using either threshold for risk strati cation (14) and others proposing that the age threshold for staging PTC should be further increased (8). For example, a previous study showed that in PTC, overall survival decreases incrementally with age and that the optimal age threshold for PTC patients is 58.5 years (8).…”

“…By contrast, the previous traditional TNM staging system used an age of 45 years (13) as a cut-off for staging, and the change to 55 years prompted a debate regarding how clinically well-founded this age cutoff point is for PTC risk strati cation, with some authors questioning the utility of using either threshold for risk strati cation (14) and others proposing that the age threshold for staging PTC should be further increased (8). For example, a previous study showed that in PTC, overall survival decreases incrementally with age and that the optimal age threshold for PTC patients is 58.5 years (8). The same researchers (8) also proposed that in terms of the age threshold for risk strati cation, PTC should not be evaluated using the same criteria as those used for FTC, and these conditions should instead be viewed as different forms of WDTC.…”

The Age Threshold of the 8th Edition AJCC Classification Is Useful for Indicating Patients with Aggressive Papillary Thyroid Cancer in Clinical Practice. 

“…Unlike other malignant tumors, patient age is regarded as an independent risk factor for PTC (5,6). PTC also presents a much poorer prognosis in elderly people, although the reason for this nding has not been clearly de ned (2,(7)(8)(9). Interestingly, PTC is unique among cancers in that patient age is part of staging (7).…”