Differences in Symptom Burden Among Cancer Patients With Different Stages of Cachexia

Zhou, Ting; Yang, Kai; Thapa, Sudip; Liu, Huiquan; Wang, Bangyan; Yu, Shiying

doi:10.1016/j.jpainsymman.2016.12.325

Cited by 48 publications

(38 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2 A randomized trial reported that a low skeletal muscle mass (sarcopenia) due to cachexia was associated with depression and quality of life in patients with advanced cancer. 16 Other studies on cancer patients revealed that systemic inflammation or elevated CRP levels were related to pain, anorexia, dyspnoea, fatigue, sleep disturbance, activities of daily living disabilities, and survival, [8][9][10][11][12][13][14][15] that these symptoms rarely existed in isolation, 11,13,39 and that pain, fatigue, and sleep disturbance were the basis of a symptom cluster in combination with reduced physical function. 14 A cross-sectional study showed a higher physical and psychological symptom burden (including pain, fatigue, sleep disturbance, distress, and anxiety) in patients with cancer cachexia, which increased with the stages of cachexia, and these findings emphasized the importance of screening for multiple co-occurring symptoms in cachexia patients.…”

Section: Discussionmentioning

confidence: 99%

“…14 A cross-sectional study showed a higher physical and psychological symptom burden (including pain, fatigue, sleep disturbance, distress, and anxiety) in patients with cancer cachexia, which increased with the stages of cachexia, and these findings emphasized the importance of screening for multiple co-occurring symptoms in cachexia patients. 13 A meta-analysis revealed that interleukin-6 (IL-6), tumour necrosis factor, and CRP were elevated in non-cancer patients with depression. 40 Other studies demonstrated that depression and cognitive dysfunction were associated with systemic inflammation due to the breakdown of the serotonergic system in cancer patients.…”

Section: Discussionmentioning

confidence: 99%

“…sleep disturbance, depression, and cognitive dysfunction, as well as physical disorders in patients with cancer. [7][8][9][10][11][12][13][14][15][16] Nevertheless, studies on CNS regulation in cancer cachexia have been limited to investigations on the systemic levels of neuromodulatory peptides, such as appetite-regulating hormones. 2 Moreover, 'sickness behaviour' has been reported in infected mammals and recognized as a symptom cluster, including fatigue, sleep disturbance, depression, and cognitive dysfunction, which is associated with systemic inflammation and its impact on the CNS.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

C‐reactive protein, delirium, and other psychological symptoms among patients with advanced cancer

Amano¹,

Hatano

Matsuda

et al. 2020

JCSM Clinical Reports

View full text Add to dashboard Cite

BackgroundIt remains unclear whether a relationship exists between elevated C‐reactive protein (CRP) levels and delirium. The primary aim was to investigate the relationship between CRP and delirium in advanced cancer.MethodsThis study was a multicenter prospective cohort study conducted in palliative care units. At baseline, the physicians diagnosed delirium. On the seventh day, they evaluated whether new delirium had occurred. Subjects were divided into four groups according to CRP levels. We assessed the associations between CRP levels and proportions of delirium. To evaluate the relationship between CRP and delirium, adjusted odd ratios (ORs) and 95% confidence intervals (CIs) were calculated in the logistic models.ResultsAmong 1896 patients, 1354 patients were eligible for analyses. We classified them into four groups: low (CRP < 1 mg/dl) (n = 170), moderate (1 ≤ CRP < 5 mg/dl) (n = 453), high (5 ≤ CRP < 10 mg/dl) (n = 334), and very high (10 mg/dl ≤ CRP) (n = 397). The incidence of delirium significantly increased with increasing CRP levels (P = 0.02). In model 1, significantly higher adjusted ORs than in the low CRP group were observed in the high CRP and very high CRP groups (1.63 [95% CI 1.06–2.50], P = 0.03; 1.72 [95% CI 1.13–2.62], P = 0.01, respectively). In model 2, a significantly higher adjusted OR than in the low CRP group was observed in the very high CRP group (1.61 [95% CI 1.05–2.45], P = 0.03).ConclusionsRelationships existed between elevated CRP levels and delirium.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

C‐reactive protein, delirium, and other psychological symptoms among patients with advanced cancer

Amano¹,

Hatano

Matsuda

et al. 2020

JCSM Clinical Reports

View full text Add to dashboard Cite

show abstract

“…Estudo de revisão mostra que este perfil é comum nos pacientes com câncer (9) e também que esses pacientes costumam ter uma fé, cuja contribuição positiva na aceitação e no enfrentamento de doenças é reconhecida, talvez por seu papel na manutenção do ânimo, na vontade de viver e na satisfação com a vida (10) . Muitas vezes o tratamento antineoplásico torna-se a renovação da esperança para o paciente oncológico (11)(12)(13)(14)(15)(16)(17)(18)(19) .…”

Section: Discussionunclassified

Qualidade Do Sono E Cluster De Sintomas Em Pacientes Com Câncer Em Tratamento Quimioterápico

Nunes¹,

Ceolim²

2019

Cogitare Enferm.

View full text Add to dashboard Cite

Objetivo: analisar a formação dos clusters de sintomas em pacientes oncológicos.Método: estudo longitudinal, de janeiro a junho de 2016. Foram recrutados 127 pacientes de um ambulatório público de quimioterapia de um hospital geral do Vale do Paraíba Paulista. A coleta de dados foi realizada por meio de entrevista e, para isto, foram utilizados o MD Anderson Symptom Inventory, o Índice de Qualidade do Sono de Pittsburgh e a Escala Visual Análoga de Sono. Os dados foram submetidos a análise estatística descritiva e inferencial.Resultados: três clusters de sintomas foram identificados ao longo do tempo: sintomas orgânicos e funcionais; emocionais e sono; e gastrointestinais.Conclusão: Este estudo, além de ter subsidiado o conhecimento quanto aos clusters de sintomas em pacientes com câncer em tratamento quimioterápico ambulatorial, permitiu conhecer como esses sintomas se comportam durante as quatro primeiras sessões de quimioterapia. Dessa forma, subsidiará intervenções preventivas aos sintomas.

show abstract

“…The prevalence of sensory symptoms (numbness, tightness, tingling, and burning) reported in patients with advanced cancer and in palliative care patients varies widely from 6 to 36% ( 16 – 19 ). These variations may be caused by the different characteristics of the populations investigated, but also by the differing assessment methods used.…”

Section: Discussionmentioning

confidence: 99%

Neurological Symptoms in Palliative Care Patients

2018

View full text Add to dashboard Cite

BackgroundNeurological expertise in palliative care may be required not only for patients with primary neurological disorders but also for patients with non-neurological diseases suffering from burdensome neurological symptoms. The aim of this study was to determine the prevalence of neurological diagnoses and symptoms in palliative care patients, as well as the related burden and impact on everyday life.MethodsWe analyzed retrospectively the medical records of 255 consecutive patients from a tertiary medical center, at the time point of referral to an inpatient palliative care consultation service. In addition, 100 patients prospectively answered a questionnaire which included the assessment of neurological symptoms, as well as numeric rating scales for quality of life, symptom-specific burden, and restrictions in everyday life.ResultsForty-one patients (16%) suffered from a primary neurological disease. Most decisions regarding the termination of life-sustaining measures concerned this group (20/22, 91%). Neurological symptoms (excluding pain) were documented in 122 patients (48%) with an underlying non-neurological disease. In the questionnaire study, 98/100 patients reported at least one neurological or neuropsychiatric symptom, most frequently sleeping problems (N = 63), difficulty concentrating (N = 55), and sensory symptoms (N = 50). Vertigo/dizziness (N = 19) had the greatest impact on everyday life (7.57/10 ± 2.17) and the highest symptom-specific burden (7.14 ± 2.51). Difficulty concentrating (restrictions in everyday life/burden) and pain intensity were the only symptoms significantly correlated with quality of life (r = −0.36, p = 0.009/r = −0.32; p = 0.04; r = −0.327, p = 0.003).ConclusionNeurological diseases and symptoms are frequent among palliative care patients and are often associated with a high symptom burden, which may severely affect the patients’ lives. It is thus of paramount importance to implement neurological expertise in palliative care.

show abstract

Differences in Symptom Burden Among Cancer Patients With Different Stages of Cachexia

Abstract: This study identified higher symptom burden in cancer patients with cachexia and it increased with the stages of cachexia, which emphasized the importance of screening in multiple co-occurring symptoms for cachexia patients.

Cited by 48 publications

References 43 publications

C‐reactive protein, delirium, and other psychological symptoms among patients with advanced cancer

C‐reactive protein, delirium, and other psychological symptoms among patients with advanced cancer

Qualidade Do Sono E Cluster De Sintomas Em Pacientes Com Câncer Em Tratamento Quimioterápico

Neurological Symptoms in Palliative Care Patients

Contact Info

Product

Resources

About