Differences in sphere-forming cells from keratoconic and normal corneal tissue: Implications for keratoconus pathogenesis

Li, Ye; Ismail, Salim; McGhee, Jennifer Jane; Wadhwa, Himanshu; Noord, Nikita; Werf, Bert van der; Sherwin, Trevor

doi:10.1016/j.exer.2020.108301

Cited by 2 publications

(1 citation statement)

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“…In terms of functional differences, KC-derived corneal fibroblasts deposit a thinner extracellular matrix with higher profibrotic collagen type III deposition and lower collagen type I compared to controls [ 91 , 92 ]. Stem cells derived from the corneoscleral rim likewise display decreased proliferative ability and elevated α-smooth muscle actin (α-SMA) expression in KC-derived spheroids [ 93 ]. Collectively, these in vitro findings have been consistent with the phenotype of moderate to severe KC in vivo [ 94 ], suggesting that the genetic or epigenetic features of KC are retained in early passages of primary corneal stromal cells.…”

Section: Corneamentioning

confidence: 99%

Role of Oxidative Stress in Ocular Diseases: A Balancing Act

et al. 2023

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Redox homeostasis is a delicate balancing act of maintaining appropriate levels of antioxidant defense mechanisms and reactive oxidizing oxygen and nitrogen species. Any disruption of this balance leads to oxidative stress, which is a key pathogenic factor in several ocular diseases. In this review, we present the current evidence for oxidative stress and mitochondrial dysfunction in conditions affecting both the anterior segment (e.g., dry eye disease, keratoconus, cataract) and posterior segment (age-related macular degeneration, proliferative vitreoretinopathy, diabetic retinopathy, glaucoma) of the human eye. We posit that further development of therapeutic interventions to promote pro-regenerative responses and maintenance of the redox balance may delay or prevent the progression of these major ocular pathologies. Continued efforts in this field will not only yield a better understanding of the molecular mechanisms underlying the pathogenesis of ocular diseases but also enable the identification of novel druggable redox targets and antioxidant therapies.

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Section: Corneamentioning

confidence: 99%