Differences in SPET analysis of thyroid-associated orbitopathy

Barna²,

Varga

et al. 2018

Nucl. Med. Rev.

Self Cite

The pathogenesis of Graves' orbitopathy (GO) is not completely understood. Coexistent hyperfunction of the thyroid gland is frequent; however, GO may also coexist with hypo-or euthyrodism. The course of GO is largely independent of thyroid function, although elevated serum TSH is known to negatively interfere with GO course. GO is severe in 10% of the cases; sight threatening complications may also develop. A successful therapy of GO requires the assesment of both the severity and activity of orbital inflammation. Based on relevant studies and our own experiences, the possible management choices are reviewed here. For this purpose, we compare the clinical value of imaging techniques for detecting the activity of the disease. During the last 15 years, we used 99m Tc-DTPA retrobulbar SPECT routinely in more than 1400 patients to facilitate the right therapeutic decision. This diagnostic utility simplified management decisions compared to previously applied alternative techniques. We recommended the routine use of 99m Tc-DTPA retrobulbar SPECT for the evaluation and follow-up of GO.

Section: Dtpa Uptake Values Other Diagnostic Methods and Treatment mentioning

confidence: 99%

The role of 99mTc-DTPA retrobulbar SPECT in staging and follow-up of Graves’ orbitopathy

Barna²,

Varga

et al. 2018

Nucl. Med. Rev.

Self Cite

Retrobulbar ^99mTc-Diethylenetriamine-Pentaacetic-Acid Uptake May Predict the Effectiveness of Immunosuppressive Therapy in Graves' Ophthalmopathy

Ujhelyi

Erdei

et al. 2009

Thyroid

Corticosteriod treatment is associated with a decline in DTPA uptake in a fraction of GO patients. GO patients with a DTPA uptake above 12.28 MBq/cm(3) are more likely to have a favorable response to corticosteroid therapy while patients with lower values are less likely to have this potentially favorable response. An elevated DTPA uptake may identify patients who are most likely to benefit from immunosuppressive treatment.

Imaging of disease activity in Gravesʼ orbitopathy with different methods: comparison of 99mTc-DTPA and 99mTc-depreotide single photon emission tomography, magnetic resonance imaging and clinical activity scores

Nuclear Medicine Communications

Leövey²,

Szücs-Farkas³

et al. 2005