Differences in sodium thiopental susceptibility of depressed patients as evidenced by the galvanic skin reflex inhibition threshold

Perez‐Reyes, Mario; Cochrane, Carl M.

doi:10.1016/0022-3956(67)90022-2

Cited by 15 publications

(4 citation statements)

References 17 publications

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“…inhibition threshold than do normal controls. Such evidence is consistent with a finding of Perez-Reyes and Cochrane (1967). Considerable neurophysiological evidence may be cited in support of this view (Perez-Reyes and Cochrane, 1967).…”

Section: Discussionsupporting

confidence: 84%

“…inhibition threshold was found to be unrelated to basal skin resistance before testing (Perez-Reyes and Cochrane, 1967), and to have a significantly high test-retest reliability ( r = +0.82) over two consecutive days ( Perez-Reyes and Cochrane, 1967). Furthermore it was concluded that neither the arousing influence of the first test, nor the habituating effects of repeated stimulus presentation, could explain the G.S.R.…”

Section: Introductionmentioning

confidence: 96%

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The Galvanic Skin Response Inhibition Threshold: A Preliminary Study with an Australian Sample

Byrne¹,

Tottman²

1974

Aust N Z J Psychiatry

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SYNOPSWGalvanic skin response (G.S.R) inhibition thresholds, giving an index of barbiturate tolerance, were determined for 20 depressive and 10 normal subjects. Barbiturate tolerance was found to effectively differentiate neurotic from psychotic depressives, and b d h these groups from normal cootrols. Neurotic depressives generally exhibited high GS.R. inhibition thresholds relative to normals, while psychotic depressives exhibited low thresholds relative to normals. These results are discussed in t e r n of previous research on the sedation threshold.The G.S.R. inhibition threshold was found in some groups, to be systematically influenced by manifest anxiety. However, neither depressive severity nor age influenced barbiturate tolerance. Some potential clinical and experimental uses of the G.S.R inhibition threshold are discussed.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 96%

The Galvanic Skin Response Inhibition Threshold: A Preliminary Study with an Australian Sample

Byrne¹,

Tottman²

1974

Aust N Z J Psychiatry

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“…Patients classified as suffering from “psychotic” (rather than “neurotic”) [ 60 ] and “endogenous” (rather than “non-endogenous”) [ 61 , 62 ] depression had lower EDA levels, although this finding was not consistent across all studies. Moreover, the published research on this issue [ 40 , 58 , 59 , 63 ] is highly heterogeneous with respect to NOS score (2, 5, not applicable, and 1, respectively).…”

Section: Resultsmentioning

confidence: 99%

The association between electrodermal activity (EDA), depression and suicidal behaviour: A systematic review and narrative synthesis

et al. 2018

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BackgroundElectrodermal activity (EDA) and other peripheral autonomic electrical parameters have been used as indicators of emotional states, including depressive states and suicidal state. We aimed to review EDA research systematically, focusing on EDA’s usefulness as a biomarker for depression and suicidal behaviour.MethodsWe searched MEDLINE, Scopus, Cochrane Library, and Web of Science databases, following PRISMA guidelines. The initial screening of articles was based on titles and abstracts; then the full text was reviewed. A preliminary synthesis of findings was developed using tables, thematic analysis and quality ratings.Results1287 articles were screened and 77 relevant studies were identified and included in the systematic review. The studies were fairly consistent in maintaining that hypoactive electrodermal response is an established feature of patients affected by depression. There is also preliminary evidence that monitoring EDA may help to differentiate the phases of mood disorders. A few studies provided evidence that EDA can be used to differentiate acutely suicidal subjects from depressed patients who are not severely suicidal. Although EDA has been shown to be a valid, sensitive marker of suicidal ideation, suicide attempts and violent suicidal behaviour, it also seems to be influenced to some extent by antidepressant treatment.ConclusionsMost of the studies summarised in this review are quite outdated and employed a variety of designs and methods to evaluate EDA. This limits the generalisability of the results and makes it difficult to draw clear conclusions about the role of EDA in real-world settings. Electrodermal hypoactivity seems to be a reliable feature of depression and a valid marker of suicidal risk. Nevertheless, the potential utility of EDA in diagnosis, prevention, and treatment planning for depression and suicidal behaviour, should be thoroughly studied.

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“…Inhibition Threshold Value (Perez-Reyes, 1968). This is a pharmacological measure of barbiturate drug tolerance which has been found to reliably and objectively distinguish between clinically defined groups of neurotic and psychotic depressives (Perez-Reyes & Cochrane, 1967;Byrne & Tottman, 1974). Neurotic depressives are found to exhibit a characteristically high barbiturate tolerance, while psychotic depressives exhibit a characteristically low barbiturate tolerance, both relative to normals (Perez-Reyes, 1968).…”

Section: Methodsmentioning

confidence: 97%

Some Preliminary Observations on a Questionnaire Technique for Classifying Depressive Illness: Its Relationship with Clinical Diagnosis and a Biological Technique for Depressive Classification

Byrne¹

1975

Aust N Z J Psychiatry

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A questionnaire designed to assist in the classification of depressive illness, was administered to 20 acute depressive patients and 10 normal controls. Patient classification according to the decision rules employed by the questionnaire, were compared with patient classification arrived at by symptomatic (diagnostic) and physiological (G.S.R. inhibition threshold) means. It was found that a preponderance of patients classified as "endogenous depressives" by the questionnaire technique, also had clinical diagnoses of endogenous depression, and had low G.S.R. inhibition thresholds relative to normals. Furthermore a preponderance of patients classified as "non-endogenous depressives" by the questionnaire technique, had clinical diagnoses of neurotic depressive illness, and had high G.S.R. inhibition thresholds relative to normals. This supports the assertion that the questionnaire technique has some validity in the classification of depressive illness.

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Differences in sodium thiopental susceptibility of depressed patients as evidenced by the galvanic skin reflex inhibition threshold

Cited by 15 publications

References 17 publications

The Galvanic Skin Response Inhibition Threshold: A Preliminary Study with an Australian Sample

The Galvanic Skin Response Inhibition Threshold: A Preliminary Study with an Australian Sample

The association between electrodermal activity (EDA), depression and suicidal behaviour: A systematic review and narrative synthesis

Some Preliminary Observations on a Questionnaire Technique for Classifying Depressive Illness: Its Relationship with Clinical Diagnosis and a Biological Technique for Depressive Classification

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