Differences in single and aggregated nanoparticle plasmon spectroscopy

Singh, Prabha; Deckert‐Gaudig, Tanja; Schneidewind, H.; Kirsch, K.; Lantman, Evelien M. van Schrojenstein; Weckhuysen, Bert M.; Deckert, Volker

doi:10.1039/c4cp04850d

Cited by 17 publications

(13 citation statements)

References 40 publications

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“…Bands detected within +/− 5 cm −1 were considered to be identical modes; such position variation always has to be accounted for and is a typical feature for small sample volumes, such as those used in TERS. Due to the high lateral resolution, only a few molecules are probed, and the statistical averaging of distinct band positions, such as in SERS, cannot be achieved 41 42 . It is apparent that several modes, represented by the light blue spots, were concurrently detected within the first 6 nm of the measured line.…”

Section: Resultsmentioning

confidence: 99%

Spatially resolved spectroscopic differentiation of hydrophilic and hydrophobic domains on individual insulin amyloid fibrils

Deckert‐Gaudig

Kurouski

Hedegaard

et al. 2016

Sci Rep

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The formation of insoluble β-sheet-rich protein structures known as amyloid fibrils is associated with numerous neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. A detailed understanding of the molecular structure of the fibril surface is of interest as the first contact with the physiological environment in vivo and plays a decisive role in biological activity and associated toxicity. Recent studies reveal that the inherent sensitivity and specificity of tip-enhanced Raman scattering (TERS) renders this technique a compelling method for fibril surface analysis at the single-particle level. Here, the reproducibility of TERS is demonstrated, indicating its relevance for detecting molecular variations. Consequently, individual fibrils are systematically investigated at nanometer spatial resolution. Spectral parameters were obtained by band-fitting, particularly focusing on the identification of the secondary structure via the amide III band and the differentiation of hydrophobic and hydrophilic domains on the surface. In addition multivariate data analysis, specifically the N-FINDR procedure, was employed to generate structure-specific maps. The ability of TERS to localize specific structural domains on fibril surfaces shows promise to the development of new fibril dissection strategies and can be generally applied to any (bio)chemical surface when structural variations at the nanometer level are of interest.

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Section: Resultsmentioning

confidence: 99%

Spatially resolved spectroscopic differentiation of hydrophilic and hydrophobic domains on individual insulin amyloid fibrils

Deckert‐Gaudig

Kurouski

Hedegaard

et al. 2016

Sci Rep

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“…While usually higher enhancements can be achieved by clusters of particles, a single particle is the preferred geometry of a TERS probe, as this excludes complex interactions between many nanoparticles and would allow a tailored design regarding their resonance wavelength. The slight deviations from the usual uniformity are not unexpected and have been addressed in a recent study as effects of the very small sample volume in TERS [36].…”

Section: Ters Measurementsmentioning

confidence: 88%

High precision attachment of silver nanoparticles on AFM tips by dielectrophoresis

et al. 2016

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AFM tips are modified with silver nanoparticles using an AC electrical field. The used technique works with sub-micron precision and also does not require chemical modification of the tip. Based on the electrical parameters applied in the process, particle density and particle position on the apex of the tip can be adjusted. The feasibility of the method is proven by subsequent tip-enhanced Raman spectroscopy (TERS) measurements using the fabricated tips as a measurement probe. Since this modification process itself does not require any lithographic processing, the technique can be easily adapted to modify AFM tips with a variety of nanostructures with pre-defined properties, while being parallelizable for a potential commercial application.

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“…For instance, the changes of adsorbate/analyte spectral features can be caused by any of the following reasons: molecule reorientation, conformational transitions, protonation of functional group, coadsorption of ions, and so forth . In a number of recent studies, it was found that an aggregation of metal nanoparticles also can induce the changes of SERS profile . These observations deserve a particular attention due to their connection to another burning issue of SERS spectroscopy, namely, to the hot spots phenomenon.…”

Section: Introductionmentioning

confidence: 99%

Surface‐enhanced Raman scattering of 4,4'‐diaminostilbene: Dependence of spectral features and resonant enhancement on surface coverage

Solovyeva

2019

J Raman Spectroscopy

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At any applications of surface‐enhanced Raman scattering (SERS) spectroscopy, from detection of small ions to recognition of large biological molecules, an understanding the spectral profiles and its transformation occurring under changes of local environment is an important stage essential for a reliable chemical analysis. In this work, we showed that the adsorption of 4,4'‐diaminostilbene on Ag nanoparticles is accompanied by a dramatic change in the SERS profile observed at transition from submonolayer to multilayer coverage. A profile deconvolution analysis allowed revealing the spectral signatures inherent for the surface species existing at submonolayer and multilayer adsorption corresponding to the hot spots and ordinary conditions, respectively. A resonance character of Raman enhancement was detected in the case of 4,4'‐diaminostilbene adsorbed in hot spots regions. A feasibility of ligand to metal charge transfer was proved on the basis of ultraviolet–visible data. The overtones and combination bands were observed in the SERS spectra at resonance conditions. The spectral signatures of the molecules inside and outside hot spots regions were assigned. A considerable activation of rings vibrations together with a suppression of ethylenic bridge vibrations was revealed in both cases. The most prominent features of 4,4'‐diaminostilbene linked with two Ag nanoparticles in the range 200–1,800 cm‐1 are the medium bands at 581 and 1249 cm‐1 corresponding to CCC bending and C–N stretching modes, respectively. The obtained results can serve as a basis for development of new powerful Raman techniques for evaluation of surface coverage and “hot spots mapping,” which are of great interest for surface science and plasmonics.

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Differences in single and aggregated nanoparticle plasmon spectroscopy

Cited by 17 publications

References 40 publications

Spatially resolved spectroscopic differentiation of hydrophilic and hydrophobic domains on individual insulin amyloid fibrils

Spatially resolved spectroscopic differentiation of hydrophilic and hydrophobic domains on individual insulin amyloid fibrils

High precision attachment of silver nanoparticles on AFM tips by dielectrophoresis

Surface‐enhanced Raman scattering of 4,4'‐diaminostilbene: Dependence of spectral features and resonant enhancement on surface coverage

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