Differences in serum metabolome profile explain individual variation in growth performance of young goats

Exploring the Rumen Microbiota and Serum Metabolite Profile of Hainan Black Goats with Different Body Weights before Weaning

“…In humans, Van der Beek et al [53] observed that acetate infusion in the distal colon alters systemic lipid metabolism, impacting plasma triglyceride levels and body weight. Therefore, the growth rate of individual animals can be influenced by variations in their microbiota and metabolic profiles [54]. Drawing from these findings, we speculate that Prevotellaceae_UCG-001 elevates VFA concentrations in the rumen, which in turn augments the lipid content in the serum of goat kids before weaning.…”

Effects of different feeding methods on serum biochemical indexes, metabolic indexes, immune indexes, and intestinal microorganisms of Nanjiang yellow goats

“…Metabolites are endogenous small molecular compounds, such as amino acids, sugars, lipids, nucleic acids, etc., that participate in the metabolism of an organism and maintain its normal growth and developmental functions, and the production and accumulation of these metabolites reflect the state of the biological system and the dynamic process of the whole system [26,28] . Metabolomics technology can use different analytical methods, such as mass spectrometry, nuclear magnetic resonance (NMR), and liquid chromatography, to detect and quantify metabolites, thus revealing the metabolic state and function of an organism.…”

“…Therefore, it is important to explore the effects of different feeding practices on intestinal metabolites to reveal the intestinal development mechanism of Nanjiang yellow goats. Wang et al found that the levels of 43 of these serum metabolites were notably elevated in high-growth goats by comparing the serum metabolism differences between high-growth and low-growth goats, including Dornithine, l-glutamine, L-histidine, myosin, lysophosphatidylinositolase, DCTP, and hydroxylysine; the levels of 82 serum metabolites were remarkably higher in lowgrowth rate goats, including p-salicylic acid and deoxycholic acid 3-glucuronide [28]. Wang et al explored the effects of dietary energy and protein on the rumen bacterial composition and rumen metabolites of the velvet goats and found that there was a significant difference in the metabolites between the high-energy, high-protein group and the control group.…”

Comparative metabolomics reveals serum metabolites changes in goats during different developmental stages

“…Compared to other domestic animals, goat metabolomics is relatively limited. Studies have shown that through the analysis of the serum metabolome of female Guanzhong goats, it was found that there were differences in glucose and lipid metabolism in high and low daily weight gain goats 11 . Metabolomic analysis of Spanish goats affected by diet and stress has shown that fatty acid metabolism is the main energy pathway in all goat populations during prolonged stress 12 .…”