Differences in rates of percutaneous coronary intervention, cardiac surgery and all-cause mortality in indigenous and non-indigenous Australians with suspected acute coronary events

Abstract

Background Indigenous populations globally are known to have lower revascularisation rates following acute coronary events and higher mortality partly due to inequitable access to specialised care like cardiac catheterisation. Whether these disparities persist when access is readily available is unclear. Purpose We compared the rates of percutaneous coronary intervention (PCI), cardiac surgery, 30-day and long-term all-cause mortality in Indigenous (Aboriginal and Torres Strait Islanders) and non-Indigenous Australians in Far North Queensland (FNQ) – a region with a large Indigenous population and 24/7 cardiac catheterisation facilities. Method All public patients in FNQ having their first inpatient angiogram from November 2012 to October 2019 were identified. The primary study outcomes were rates of PCI or cardiac surgery and all-cause mortality at 30 days and long term. Secondary study outcomes were significant left ventricular dysfunction (ejection fraction <50%) and valvular disease (moderate to severe) in the echocardiogram subset. Other differences in baseline characteristics, including age, gender, body mass index, postcode and indication for angiography were accounted for using logistic and cox regression analysis. Results We identified 4489 patients (mean age, 61.7±13.0 years, 64.9% male, median follow-up 1045 days). 1042 (23.2%) self-identified as Indigenous. Indigenous patients were younger (53.7±11.6 vs 64.1±12.5 years, p<0.001), more likely female (45.5% vs 32.0%, p<0.001) and had small differences in angiography indications, ST elevation myocardial infarction (STEMI) 19.1% vs 18.1%, non-STEMI 45.7% vs 41.8%, angina 26.3% vs 28.0%, cardiac arrest 3.1% vs 3.7% and other 5.8% vs 8.4%, p=0.02. Rates of PCI or surgery 35.6% vs 38.5%, p=0.17, 30-day mortality 1.9% vs 2.7%, p=0.17 and long-term mortality 11.0% vs 11.5%, p=0.71 were similar in unadjusted data. 2959 patients (mean age, 62.1±13.0 years, 23.1% Indigenous, 64.9% male) were included in the echocardiogram subgroup. In unadjusted data Indigenous patients had similar rates of ventricular dysfunction 33.3% vs 31.3%, p=0.33 and valvular disease 19.4% vs 19.3%, p=0.93. After adjustment for other baseline characteristics, Indigenous patients had higher rates of PCI or cardiac surgery, OR 1.39 (95% CI, 1.18–1.64, p<0.001), ventricular dysfunction, OR 1.31 (95% CI, 1.07–1.60), p=0.01 and valvular disease, OR 1.93 (95% CI, 1.50–2.48), p<0.001. 30-day mortality was similar but Indigenous patients had higher adjusted long-term hazard of mortality, HR 1.80 (95% CI, 1.42–2.27), p<0.001. Conclusion When cardiac catheterisation was readily available Indigenous patients had higher rates of PCI and cardiac surgery and similar 30-day mortality to non-Indigenous patients. Equitable access to healthcare improves outcomes but the nearly double long-term mortality of Indigenous patients shows more is required to help close the gap for disadvantaged populations. Funding Acknowledgement Type of funding source: None

A Systematic Review and Meta-Analysis of Percutaneous Coronary Intervention (PCI) and Coronary Bypass Grafting (CABG) Outcomes in Indigenous vs. Non-Indigenous Australians

“…The purpose of this study was to compare the patient characteristics, presentations, and outcomes of indigenous and non-indigenous Australians undergoing PCI in metropolitan and larger regional centers in Victoria, Australia. Victoria is a state in the southeast of the nation with a population of about 6.4 million people, or 7.2% of Australia's indigenous population [8].…”

“…The purpose of this study was to compare the patient characteristics, presentations, and outcomes of indigenous and non-indigenous Australians undergoing PCI in metropolitan and larger regional centers in Victoria, Australia. Victoria is a state in the southeast of the nation with a population of about 6.4 million people, or 7.2% of Australia's indigenous population [ 8 ]. There is a notable dearth of thorough data comparing the results of percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) between indigenous and non-indigenous populations in Australia, despite the significant burden of cardiovascular disease (CVD) among indigenous Australians.…”