Differences in race, molecular and tumor characteristics among women diagnosed with invasive ductal and lobular breast carcinomas

Williams, Lindsay A.; Hoadley, Katherine A.; Nichols, Hazel B.; Geradts, Joseph; Perou, Charles M.; Love, Michael I.; Olshan, Andrew F.; Troester, Melissa A.

doi:10.1007/s10552-018-1121-1

Cited by 23 publications

(33 citation statements)

References 52 publications

(66 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[32] . However, Williams and colleagues reported that malignant axillary deposit increase in ductal than in lobular and mixed carcinoma [33] In this study statistical analysis reported that tumor grade 2 had positive metastatic axillary lymph node more than tumor grad 3. Chisthi et al [13] reported that, grade 2 tumors cells tend to be slow growing which occur at invasive tumor growth cycle is longer and this increase opportunity of lymphovascular invasion.…”

Section: Chakraborty Et Al Reported Results Of 426 Patients With Bcmentioning

confidence: 61%

Factors Affecting Nodal Status in Breast Cancer

Aboelata

Sarhan

Mira

et al. 2020

International Journal of Medical Arts

View full text Add to dashboard Cite

Background: Nodal status in breast cancer [BC] is the most prognostic factor for survival and prognosis, and affects treatment decisions. Nodal status had reciprocal relation with pre-and post-operative factors. All these reflect the crucial importance of nodal status in BC. Aim of the work: Evaluation of pre-and post-operative factors related to nodal status in breast cancer. Patients and Methods: The current work included 40 patients with confirmed BC, who had been scheduled for modified radical mastectomy or conservative breast surgery with axillary evacuation. All were assessed in a systematic manner preoperatively. In addition, an intraoperative and post-operative evaluation had been carried out. Postoperative histopathological examination of excised tissues had been done for all specimens. Both intra-and post-surgical complications and factors associated with positive nodal status were documented. Results: The most significant factors associated with high positive nodal status were age [patient ≤ 45 years was significantly associated with increased positive nodes when compared to > 45 years [37.68±35.23 vs 17.66±19.45 respectively], obesity [30.66±27.33 vs 18.49±25.07 nodes for obese and lean individuals respectively]., tumors greater than 2 cm, positivity of the human-epidermal-growth-factor receptor 2 [Her2]/neu, positive lymphovasular invasion, tumors of the upper quadrant, and the type of histopathology. Conclusion: Nodal status affected by pre-and post-surgery factors [e.g., age, obesity, tumor site, tumor size, Her2/neu, lymphovascular invasion and histopathological type of the tumor]. Thus, these factors help in planning of the treatment such as the type of surgery, endocrine therapy, radiation therapy and the adjuvant chemotherapy.

show abstract

Section: Chakraborty Et Al Reported Results Of 426 Patients With Bcmentioning

confidence: 61%

Factors Affecting Nodal Status in Breast Cancer

Aboelata

Sarhan

Mira

et al. 2020

International Journal of Medical Arts

View full text Add to dashboard Cite

show abstract

“…The percentage of cells stained for antibodies was verified by a binocular microscope (Zeiss KF2 binocular, Germany). The positivity of HER2 was defined when the membrane/membrane plus cytoplasmic staining by antibody (A0485, 1/200; Dako Denmark A/S) classified as the weak or greater intensity at ≥10% of tumor cells 39 . The antibody used for ER staining was Clone ID5; Dako Denmark A/S (Glostrup, Denmark).…”

Section: Methodsmentioning

confidence: 99%

The contribution of dietary and plasma folate and cobalamin to levels of angiopoietin-1, angiopoietin-2 and Tie-2 receptors depend on vascular endothelial growth factor status of primary breast cancer patients

Pirouzpanah

Varshosaz

Fakhrjou

et al. 2019

Sci Rep

View full text Add to dashboard Cite

The aim of this study was to determine the association of dietary folate and cobalamin with plasma levels of Angiopoietins (ANG), vascular endothelial growth factor-C (VEGF-C) and tyrosine kinase receptor-2 (Tie-2) of primary breast cancer patients. Women (n = 177), aged 30 to 75 years diagnosed with breast cancer were recruited from an ongoing case series study. Dietary intake of nutrients was estimated by using a validated food frequency questionnaire. Enzyme-linked immunosorbent assay was applied to measure biomarkers. MCF-7 cell cultures were supplemented with folic acid (0–40 μM) for 24 h to measure cell viability and fold change of expression by the real-time reverse transcriptase-polymerase chain reaction. Structural equation modeling was applied to analyze the structural relationships between the measured variables of nutrients and Angiopoietins. Dietary intake of folate and cobalamin showed a significant inverse correlation with plasma ANG-1 and ANG-2 (P < 0.05), particularly in subjects with estrogen-receptor positive tumors or low plasma VEGF-C. Plasma folate was positively associated with the ratio of ANG-1/ANG-2 (P < 0.05). Residual intake levels of total cobalamin were inversely associated with plasma ANG-1 when plasma stratum of VEGF-C was high (P < 0.05). Structural equation modeling identified a significant inverse contribution of folate profiles on the latent variable of Angiopoietins (coefficient β = −0.99, P < 0.05). Folic acid treatment resulted in dose-dependent down-regulations on ANGPT1 and ANGPT1/ANGPT2 ratio but VEGF and ANGPT2/VEGF were upregulated at folic acid >20 μM. Studying the contributing role of dietary folate to pro-angiogenic biomarkers in breast cancer patients can infer the preventive role of folate in the ANGs/VEGF-C-dependent cascade of tumor metastasis. By contrast, high concentrations of folic acid in vitro supported VEGF-C-dependent ANGPT2 overexpression might potentiate micro-lymphatic vessel development to support malignant cell dissemination.

show abstract

“…The percentage of stained cells by the antibodies was examined using a binocular microscope (Zeiss KF2 binocular, Germany). HER2 positivity was determined when the membrane/membrane plus cytoplasm stained by antibody (A0485, 1/200; Dako Denmark A/S) accounted for ≥ 10% of tumor cells (28). The Clone ID5 (Dako Denmark A/S) antibody (Glostrup, Denmark) was applied to detect the frequency of cells with ER positivity.…”

Section: Histopathological Datamentioning

confidence: 99%

Inflammatory potential of diet in association with breast cancer risk: A matched case-control study

Hayati

Montazeri

Shivappa

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The present study aimed to explore the association between the dietary inflammatory index (DII ® ) and the risk of different molecular subtypes of breast cancer (BrCa) for the first time in a large population-based case-control study conducted in Iran.Methods: The subjects consisted of 1007 women with histopathologically confirmed BrCa, and 1004 controls admitted to hospitals in Tabriz, Iran, for non-neoplastic conditions. The DII scores were computed based on dietary intake collected using a validated 136-item food frequency questionnaire. Energy-adjusted DII (E-DII TM ) also were calculated. Conditional logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs).Results: The pro-inflammatory diet [highest E-DII quartile (Q)] vs. the anti-inflammatory diet (lowest E-DII scores) showed significantly increased BrCa risk (OR Q4 vs. Q 1 : 1.87; 95% CI: 1.42‒2.47). This was aligned with the findings obtained in women at reproductive ages (premenopausal status) who diagnosed with luminal A [estrogen receptor-positive (ER + ) and/or progesterone receptor-positive (PR + ) and human epidermal growth factor receptor 2-negative (HER2 - )] (OR Q4 vs. Q 1 : 2.71; 95% CI: 1.74‒4.22) and luminal B (ER + and/or PR + , HER2 + ) (OR Q4 vs. Q 1 : 2.86; 95% CI: 1.39‒5.89). Women in the highest E-DII quartile were three times more likely to have triple-negative BrCa (ER - , PR - , HER2 - ) compared to luminal A (OR Q4 vs. Q1 : 3.00; 95% CI: 1.002‒8.96). Likewise, the risk of HER2-enriched BrCa (ER - , PR - and HER2 + ) vs. luminal B subtype was increased among those consumed the most pro-inflammatory E-DII (OR Q4 vs. Q1 : 2.44; 95% CI: 1.01‒5.88). A significant ascending trend was observed in mean E-DII scores, followed by rising tumor size (P=0.018).Conclusions: The pro-inflammatory diet, as indicated by increasing E-DII scores, was a risk factor of BrCa in Iranian women, providing updates to the invasive molecular subtypes of BrCa. Diets modulated for high anti-inflammatory and low pro-inflammatory dietary components are suggested to prevent the risk of more aggressive forms of BrCa.

show abstract

Differences in race, molecular and tumor characteristics among women diagnosed with invasive ductal and lobular breast carcinomas

Cited by 23 publications

References 52 publications

Factors Affecting Nodal Status in Breast Cancer

Factors Affecting Nodal Status in Breast Cancer

The contribution of dietary and plasma folate and cobalamin to levels of angiopoietin-1, angiopoietin-2 and Tie-2 receptors depend on vascular endothelial growth factor status of primary breast cancer patients

Inflammatory potential of diet in association with breast cancer risk: A matched case-control study

Contact Info

Product

Resources

About