Differences in prevalence of hepatitis B virus infection and genotypes between ethnic populations in Suriname, South America

Ottevanger, M.S. MacDonald –; Boyd, Anders; Prins, Maria; Helm, Jürgen; Zijlmans, Wilco; Hindori-Mohangoo, Ashna D.; Harkisoen, Soeradj; Hermelijn, Sandra; Brinkman, Kees; Codrington, John; Roosblad, Jimmy; Kort, S.A.R.; Dams, Els; Laar, T.J.W. van de; Vreden, Stephen

doi:10.1016/j.virol.2021.09.005

Cited by 3 publications

(7 citation statements)

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“…The cause of this overrepresentation is not yet confirmed but could most likely be explained by the high prevalence of HBV within this subgroup. The study by Mac Donald et al also found strong ethnic clustering of the Indonesian sub-genotype HBV/B3 among Javanese descendants and HBV/A1 sub-genotype among African descendants 9 . In the same study ethnicity, age, cohabitation and education level were found to be associated with HBsAg positivity 9 .…”

Section: Introductionmentioning

confidence: 89%

“…Twenty regions suspected, based on ethnic variation of inhabitants, to have a diverse prevalence of HBV and HCV were screened 9, 14 . All participants over the age of 18 willing to get tested were included during the months of July, August and September of 2022.…”

Section: Methodsmentioning

confidence: 99%

“…From the pilot studies we have been able to perform thus far, we can already draw several important conclusions and define additional recommendations. Firstly, in Suriname, Javanese ethnicity is an important risk factor for contracting HBV and HCV 9, 14 . In rural villages in the district of Commewijne, where the majority of the inhabitants are of Javanese ethnicity, positivity rates approaching 30% were seen underscoring the need for a coordinated plan of action.…”

Section: Conclusion and Recommendationsmentioning

confidence: 99%

“…The first HBV vaccine was developed in 1981 and ever since the prevalence of HBV in children under the age of 5 has been declining to an all-time low of 1% in 2019 3, 8 . In Suriname, the prevalence of HBV is 3% and since 2003, HBV vaccination in newborns has been implemented 9 . All pregnant women in Suriname are tested during their antenatal screening.…”

Section: Introductionmentioning

confidence: 99%

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The road to achieving viral hepatitis elimination in Suriname: The progress, the challenges and the goals

Loe-Sack-Sioe,

Neus,

Woittiez

et al. 2024

Preprint

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Background: Viral hepatitis is one of the leading causes of liver failure, cirrhosis, hepatocellular cancer and mortality worldwide and has long had limited treatment options. Estimates suggest that around 30% of the global population has at one point been infected with HBV, while 3.9% are chronically infected. 1.6 – 2.8% of the world population is estimated to be infected with HCV. With the introduction of the HBV birth-dose vaccines, HBV immunoglobulins and the more recent development of the HCV direct-acting antiviral medication, HBV and HCV infections have now become containable diseases. In 2016, all 194 member states of the World Health Organization endorsed the public-health goal to eradicate viral hepatitis by 2030. Yet, as of 2023, only a small group of countries are on course to achieving this goal. Suriname, a small, multi-ethnic country, located in the north of South America, has an intermediate prevalence of HBV and HCV of 3% and 1% respectively. Previously performed studies, however, show strong ethnic clustering in Suriname. Aim: With this manuscript we dissect the strategy we developed to tackle the hepatitis challenge in Suriname. We explain the importance of establishing more detailed insight into the geographical distribution of high-prevalence areas, as linked to the ethnic differences in the population. We present the screening and contact tracing approaches and end with our current insights on how to proceed toward further prevention and treatment options. Overall, we provide a blueprint towards eliminating viral hepatitis with simple and effective strategies usable in resource-limited countries with an intermediate to high prevalence of viral hepatitis.

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Section: Introductionmentioning

confidence: 89%

Section: Methodsmentioning

confidence: 99%

Section: Conclusion and Recommendationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The road to achieving viral hepatitis elimination in Suriname: The progress, the challenges and the goals

Loe-Sack-Sioe,

Neus,

Woittiez

et al. 2024

Preprint

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“…Available data in FG and Suriname are mainly confined to the urban areas: in Cayenne (FG), VH has strong ethnic clustering with HBV and HCV prevalence ranging between 0 and 11%, and 0 to 4.7% respectively, among various ethnic groups ( 24 , 25 ). Similarly, in Paramaribo (Suriname), prevalence varies greatly, between 0.5 to 6.5% for HBV ( 26 ) and 0.6 to 4.1% for HCV ( 27 ).…”

Section: Introductionmentioning

confidence: 99%

Involving hard-to-reach populations is pivotal for the tailoring and implementation of an epidemiological study in cross-border communities of French Guiana and Suriname

Schaub,

Ottevanger,

Harkisoen

et al. 2023

Front. Public Health

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BackgroundHard-to-reach, vulnerable and cross-border populations are often disproportionately affected by communicable diseases. Epidemiological data on viral hepatitis in French Guiana and Suriname are available for urban areas, but not for remote communities. The Maroni River, which separates FG and Suriname, is home to Tribal and Indigenous communities. Reaching these populations is challenging due to logistical constraints, cultural and language barriers, and mistrust of outsiders.ObjectivesWe aimed to conduct an epidemiological study of viral hepatitis [Maroni Hepatites Virales (MaHeVi)] in this remote and complex area. Here, we describe the operational hurdles and solutions required to achieve this.MethodsWe undertook a preliminary assessment of the area with local community leaders and health workers to gain approval of MaHeVi, acceptance of blood sampling, and suggestions for adapting the study to cultural and logistical constraints. Anthropological assessments were conducted through focus groups and interviews with key individuals to assess knowledge, beliefs and risk factors for VH.ResultsMaHeVi was well received by the local communities. The approval of the community leaders was crucial for the implementation and acceptance of the study. The main adaptations were hiring community health mediators to overcome cultural and language differences, using blotting paper instead of venipuncture for logistical and acceptability reasons, and adapting communication materials.ConclusionCareful preparation and tailoring of the communication materials and research protocol have enabled the successful implementation of the study. This process could be replicated in this area and transferred to other complex contexts combining borders, logistical hurdles and populations requiring cultural adaptations.

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Entrepreneurship in Suriname

Salamzadeh

Романович

2022

Springer Texts in Business and Economics

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Differences in prevalence of hepatitis B virus infection and genotypes between ethnic populations in Suriname, South America

Cited by 3 publications

References 35 publications

The road to achieving viral hepatitis elimination in Suriname: The progress, the challenges and the goals

The road to achieving viral hepatitis elimination in Suriname: The progress, the challenges and the goals

Involving hard-to-reach populations is pivotal for the tailoring and implementation of an epidemiological study in cross-border communities of French Guiana and Suriname

Entrepreneurship in Suriname

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