Differences in phenotypes, symptoms, and survival in patients with cardiomyopathy—a prospective observational study from the Sahlgrenska CardioMyoPathy Centre

Ljungman, Charlotta; Bollano, Entela; Rawshani, Araz; Backelin, Charlotte Nordberg; Dahlberg, Pia; Valeljung, I.; Björkenstam, Marie; Hjalmarsson, Clara; Fu, Michael; Mellberg, Tomas; Bartfay, Sven‐Erik; Polte, Christian L.; Andersson, Bert; Bergh, Niklas

doi:10.3389/fcvm.2023.1160089

Cited by 3 publications

(1 citation statement)

References 25 publications

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“…According to symptoms distribution, the present study showed that there were 7 patients who had acute chest pain (14%), 13 patients (26%) had dyspnea, and 13 patients (26%) had lower limb edema. According to a recent study by Ljungman et al (14) , the kind of cardiomyopathy had some influence on the first symptoms. The cohort's most prevalent symptom at beginning was dyspnea (63.3%), which was followed by exhaustion (51.9%) and chest discomfort (30.5%).…”

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confidence: 98%

The Additive Value of Cardiac MRI in Cases of Cardiomyopathy

2024

The Egyptian Journal of Hospital Medicine

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Background: Worldwide, myocardial diseases are major contributors to patient morbidity and death. Cardiovascular Magnetic Resonance (CMR) has gained recognition as a useful clinical technique that may evaluate ventricular function and volumes, myocardial fibrosis, iron loading, flow measurement, tissue characterisation, and myocardial perfusion imaging all in a single scan scenario.Objective: This study aimed to identify the role and diagnostic potential of cardiac magnetic resonance imaging to diagnose cardiomyopathy. Patients and methods: A cross-sectional study that was conducted through the period from October 2020 to May 2022 at Radio Diagnosis Department, National Heart Institute. The study involved 50 patients who had clinical suspicion of cardiomyopathy. They were referred from Cardiology Department. The mean age of patients was 57.42 ± 6.45 years. Results: There was a significant difference between Echo and Cardiac MRI regarding ejection fraction and end diastolic volume among the studied patients. Also, EF% was significantly higher with cardiac MRI (45.60 ± 8.12%) compared to Echo (43.00 ± 7.49%), with a mean difference of 2.60 ± 2.42%. Furthermore, EDV/ml was significantly higher with cardiac MRI (161.54 ± 48.14 ml) compared to Echo (158.50 ± 46.38 ml), with a mean difference of 3.04 ± 5.26 ml. Conclusion: Cardiac magnetic resonance technique was more accurate for diagnosis among patients suspicioned of cardiomyopathy compared to echocardiography.

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confidence: 98%

The Additive Value of Cardiac MRI in Cases of Cardiomyopathy

2024

The Egyptian Journal of Hospital Medicine

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Management of cardiac sarcoidosis

Sharma,

Kouranos,

Cooper

et al. 2024

European Heart Journal

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Cardiac sarcoidosis (CS) is a form of inflammatory cardiomyopathy associated with significant clinical complications such as high-degree atrioventricular block, ventricular tachycardia, and heart failure as well as sudden cardiac death. It is therefore important to provide an expert consensus statement summarizing the role of different available diagnostic tools and emphasizing the importance of a multidisciplinary approach. By integrating clinical information and the results of diagnostic tests, an accurate, validated, and timely diagnosis can be made, while alternative diagnoses can be reasonably excluded. This clinical expert consensus statement reviews the evidence on the management of different CS manifestations and provides advice to practicing clinicians in the field on the role of immunosuppression and the treatment of cardiac complications based on limited published data and the experience of international CS experts. The monitoring and risk stratification of patients with CS is also covered, while controversies and future research needs are explored.

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Hypertrophic cardiomyopathy and left ventricular non-compaction: Distinct diseases or variant phenotypes of a single condition?

Przytuła,

Dziewięcka,

Winiarczyk

et al. 2024

World J Cardiol

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Hypertrophic cardiomyopathy (HCM) is a genetically determined myocardial disease characterized by an increased thickness of the left ventricle (LV) wall that cannot be solely attributed to abnormal loading conditions. HCM may present with an intraventricular or LV outflow tract obstruction, diastolic dysfunction, myocardial fibrosis and/or ventricular arrhythmias. Differentiating HCM from other diseases associated with LV hypertrophy, such as hypertension, aortic stenosis, or LV non-compaction (LVNC), can at times be challenging. LVNC is defined by excessive LV trabeculation and deep recesses between trabeculae, often accompanied by increased LV myocardial mass. Previous studies indicate that the LVNC phenotype may be observed in up to 5% of the general population; however, in most cases, it is a benign finding with no impact on clinical outcomes. Nevertheless, LVNC can occasionally lead to LV systolic dysfunction, manifesting as a phenotype of dilated or non-dilated left ventricular cardiomyopathy, with an increased risk of thrombus formation and arterial embolism. In extreme cases, where LVNC is associated with a very thickened LV wall, it can even mimic HCM. There is growing evidence of an overlap between HCM and LVNC, including similar genetic mutations and clinical presentations. This raises the question of whether HCM and LVNC represent different phenotypes of the same disease or are, in fact, two distinct entities.

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Differences in phenotypes, symptoms, and survival in patients with cardiomyopathy—a prospective observational study from the Sahlgrenska CardioMyoPathy Centre

Cited by 3 publications

References 25 publications

The Additive Value of Cardiac MRI in Cases of Cardiomyopathy

The Additive Value of Cardiac MRI in Cases of Cardiomyopathy

Management of cardiac sarcoidosis

Hypertrophic cardiomyopathy and left ventricular non-compaction: Distinct diseases or variant phenotypes of a single condition?

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