Differences in outcomes in patients with stable coronary artery disease managed by cardiologists versus non-cardiologists: the international prospective CLARIFY registry

Parma, Zofia; Steg, Philippe Gabriel; Greenlaw, Nicola; Ferrari, Roberto; Ford, Ian; Fox, KM; Tardif, Jean‐Claude; Gamba, Marco Alcocer; Kääb, Stefan; Tendera, Michał

doi:10.20452/pamw.3902

Cited by 2 publications

(2 citation statements)

References 13 publications

(14 reference statements)

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“…Other findings reported that CAD patients with comorbidity conditions significantly spent more days of hospitalisation than those who had no chronic conditions 30 . CAD patients were said to form a non-uniform group and their prognosis may differ depending on demographic, clinical, geographic, and socioeconomic factors 37 . Therefore, basing on such findings, this relationship could probably be well explained by clinical characteristics or other factors.…”

Section: Discussionmentioning

confidence: 99%

Comparing the association of cardiovascular nursing care with blood pressure and length of stay of in-patients with coronary artery disease in Wuhan, China

Ramadhani¹,

Liu²,

Xue³

et al. 2020

Afr H. Sci.

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Background: Coronary artery disease is a leading cause of morbidity and mortality worldwide. Comorbidity-like hyperten- sion has been among the major risks of coronary artery disease. Recent evidence identified multiple benefits of cardiovas- cular nursing care to coronary patients. However, little has been appraised on benefits regarding patients’ blood pressure control and length of hospitalisation. Objective: To compare the association of cardiovascular nursing care delivered to coronary artery patients with patients’ blood pressure and length of stay. Methods: Records based retrospective design was applied at a large teaching hospital in Wuhan, China. SPSS 21 version was used for data entry and analysis with univariate and multivariate logistic regression models for comparing study variables. Results: Of 300 patients, 224 (74.7%) were known to be hypertensive and admitted with subnormal blood pressure. Cardiovascular nursing care like “assess to grade pain severity on 1-10 scale” and “counsel patient to cope with stress” were six and three times more likely to contribute improved patients’ blood pressure (AOR=5.8; 95%CI: 2.8-12.2, p=0.001) and (AOR=3.1; 95%CI: 1.2-7.8, p=0.015) respectively. No significant difference with length of stay (p>0.05). Conclusion: There is a possibility of coronary artery patients to recover with normal blood pressure following reception of evidence-based cardiovascular nursing care. Keywords: Cardiovascular nursing care; blood pressure; in-patients; coronary artery; Wuhan; China.

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Section: Discussionmentioning

confidence: 99%

Comparing the association of cardiovascular nursing care with blood pressure and length of stay of in-patients with coronary artery disease in Wuhan, China

Ramadhani¹,

Liu²,

Xue³

et al. 2020

Afr H. Sci.

View full text Add to dashboard Cite

show abstract

“…However, microvascular disease associated with conditions such as diabetes mellitus can result in myocardial fibrosis and lead to heart failure [2]. Patients with CAD may undergo cardiac ischemic events that result in sudden death [3][4][5]. Thrombolytic therapy and percutaneous coronary intervention (PCI) are current treatment approaches for patients with myocardial ischemia and infarction, which have significantly reduced the mortality rate [6].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-668-3p Protects Against Oxygen-Glucose Deprivation in a Rat H9c2 Cardiomyocyte Model of Ischemia-Reperfusion Injury by Targeting the Stromal Cell-Derived Factor-1 (SDF-1)/CXCR4 Signaling Pathway

Gao

Liu

2020

Med Sci Monit

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Departmental sources Background: Ischemia-reperfusion injury (IRI) results from the restoration of blood supply to ischemic organs, including the heart. Expression of microRNA-668-3p (miR-668-3p) is known to protect the kidney from IRI. This study aimed to investigate the role of miR-668-3p in oxygen-glucose deprivation (OGD) in a rat H9c2 cardiomyocyte model of IRI. Material/Methods: Rat H9c2 cardiomyocytes were cultured in glucose-free Dulbecco's modified Eagle's medium (DMEM) under anaerobic conditions, followed by oxygenation, to create the OGD model of IRI. The luciferase reporter assay evaluated the interaction between stromal cell-derived factor-1 (SDF-1), or CXC motif chemokine 12 (CXCL12), and miR-668-3p. Protein and mRNA levels of SDF-1, CXCR4, Bcl2, Bax, cleaved caspase-3, endothelial nitric oxide synthase (eNOS), and phosphorylated endothelial nitric oxide synthase (p-eNOS) were analyzed by Western blot and quantitative reverse transcription-polymerase chain reaction (RT-qPCR), and apoptosis were assessed by flow cytometry. Enzyme-linked immunosorbent assay (ELISA) measured reactive oxygen species (ROS), including malondialdehyde (MDA), nitric oxide (NO), p-eNOS, and the inflammatory cytokines, tumor necrosis factor-a (TNF-a), interleukin-1b (IL-1b), IL-6, and monocyte chemoattractant protein-1 (MCP-1) in H9c2 cell supernatants. Results: In the OGD rat H9c2 cardiomyocyte model of IRI, miR-668-3p levels were reduced. Overexpression of miR-668-3p inhibited SDF-1, CXCR4, the expression of inflammatory cytokines, markers of oxidative stress, and p-eNOS. The overexpression of SDF-1 reversed these findings. Overexpression of SDF-1 promoted cell apoptosis, which was reduced by miR-668-3p. Conclusions: In the OGD rat H9c2 cardiomyocyte model of IRI, miR-668-3p suppressed mediators of inflammation and oxidative stress and enhanced cell viability through the SDF-1/CXCR4 signaling pathway.

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Differences in outcomes in patients with stable coronary artery disease managed by cardiologists versus non-cardiologists: the international prospective CLARIFY registry

Cited by 2 publications

References 13 publications

Comparing the association of cardiovascular nursing care with blood pressure and length of stay of in-patients with coronary artery disease in Wuhan, China

Comparing the association of cardiovascular nursing care with blood pressure and length of stay of in-patients with coronary artery disease in Wuhan, China

MicroRNA-668-3p Protects Against Oxygen-Glucose Deprivation in a Rat H9c2 Cardiomyocyte Model of Ischemia-Reperfusion Injury by Targeting the Stromal Cell-Derived Factor-1 (SDF-1)/CXCR4 Signaling Pathway

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